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Q18AR0 (THLA_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-CoA acetyltransferase
EC=2.3.1.9
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene names
Name:thlA
Ordered Locus Names:CD630_10590
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptostreptococcaceae ›

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Acetyl-CoA acetyltransferase
PRO_5000077784

Sites

Active site881Acyl-thioester intermediate By similarity
Active site3481Proton acceptor By similarity
Active site3781Proton acceptor By similarity

Secondary structure

1 .................................................................... 391
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q18AR0 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 7B6713CCC8F70899

FASTA39140,860
        10         20         30         40         50         60 
MREVVIASAA RTAVGSFGGA FKSVSAVELG VTAAKEAIKR ANITPDMIDE SLLGGVLTAG 

        70         80         90        100        110        120 
LGQNIARQIA LGAGIPVEKP AMTINIVCGS GLRSVSMASQ LIALGDADIM LVGGAENMSM 

       130        140        150        160        170        180 
SPYLVPSARY GARMGDAAFV DSMIKDGLSD IFNNYHMGIT AENIAEQWNI TREEQDELAL 

       190        200        210        220        230        240 
ASQNKAEKAQ AEGKFDEEIV PVVIKGRKGD TVVDKDEYIK PGTTMEKLAK LRPAFKKDGT 

       250        260        270        280        290        300 
VTAGNASGIN DGAAMLVVMA KEKAEELGIE PLATIVSYGT AGVDPKIMGY GPVPATKKAL 

       310        320        330        340        350        360 
EAANMTIEDI DLVEANEAFA AQSVAVIRDL NIDMNKVNVN GGAIAIGHPI GCSGARILTT 

       370        380        390 
LLYEMKRRDA KTGLATLCIG GGMGTTLIVK R

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM180355 Genomic DNA. Translation: CAJ67900.1.
RefSeqYP_001087540.1. NC_009089.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DD5X-ray1.25A1-391[»]
ProteinModelPortalQ18AR0.
SMRQ18AR0. Positions 4-390.
ModBaseSearch...

Protein-protein interaction databases

STRING272563.CD1059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ67900; CAJ67900; CD630_10590.
GeneID4915191.
KEGGcdf:CD630_10590.
PATRIC19440445. VBICloDif38397_1111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0183.
HOGENOMHOG000012238.
KOK00626.
OMAAMCLERP.
ProtClustDBCLSK2534674.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-1210-MONOMER.
UniPathwayUPA00058; UER00101.

Family and domain databases

Gene3D3.40.47.10. 4 hits.
InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PANTHERPTHR18919. PTHR18919. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHLA_CLOD6
AccessionPrimary (citable) accession number: Q18AR0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 25, 2006
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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