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Protein

Glucosamine-6-phosphate deaminase

Gene

nagB

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.UniRule annotation

Catalytic activityi

Alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3.UniRule annotation

Pathwayi: N-acetylneuraminate degradation

This protein is involved in step 5 of the subpathway that synthesizes D-fructose 6-phosphate from N-acetylneuraminate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. N-acetylneuraminate lyase (nanA)
  2. no protein annotated in this organism
  3. Putative N-acetylmannosamine-6-phosphate 2-epimerase (nanE)
  4. no protein annotated in this organism
  5. Glucosamine-6-phosphate deaminase (nagB)
This subpathway is part of the pathway N-acetylneuraminate degradation, which is itself part of Amino-sugar metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-fructose 6-phosphate from N-acetylneuraminate, the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptor; for enolization stepUniRule annotation1
Active sitei136For ring-opening stepUniRule annotation1
Active sitei138Proton acceptor; for ring-opening stepUniRule annotation1
Active sitei143For ring-opening stepUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1126-MONOMER
UniPathwayiUPA00629; UER00684

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosamine-6-phosphate deaminaseUniRule annotation (EC:3.5.99.6UniRule annotation)
Alternative name(s):
GlcN6P deaminaseUniRule annotation
Short name:
GNPDAUniRule annotation
Glucosamine-6-phosphate isomeraseUniRule annotation
Gene namesi
Name:nagBUniRule annotation
Ordered Locus Names:CD630_10110
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000669701 – 249Glucosamine-6-phosphate deaminaseAdd BLAST249

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1011

Structurei

3D structure databases

ProteinModelPortaliQ18AL0
SMRiQ18AL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKA Bacteria
COG0363 LUCA
HOGENOMiHOG000064978
KOiK02564
OMAiSYHYFMK

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit

Sequencei

Sequence statusi: Complete.

Q18AL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLVCKDYD GMSKKAAEMI AAQIVLKPNS ILGLATGSTP VGMYRDLVKK
60 70 80 90 100
YNDNIVDFSD VMSFNLDEYY KLPISNDQSY DYFMKENLFN HVNIKPENTH
110 120 130 140 150
LPNGMADDIE KECMNYEASI DAAGGIDVQV LGIGRNAHIG FNEPDTKFAK
160 170 180 190 200
RTHVVELTES TIEANARFFK SREDVPKKAV SMGIGSILKS KKILLLASGE
210 220 230 240
EKADAVYNTV YGDITPEVPG SILQLHKDTI VIVDEAAASK LNPKDYKLV
Length:249
Mass (Da):27,590
Last modified:July 25, 2006 - v1
Checksum:i380E10F5C9DDF884
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ67852.1
RefSeqiWP_003437039.1, NZ_CP010905.2
YP_001087492.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ67852; CAJ67852; CD630_10110
GeneIDi31352573
4914486
KEGGicdf:CD630_10110
pdc:CDIF630_01147
PATRICifig|272563.120.peg.1050

Similar proteinsi

Entry informationi

Entry nameiNAGB_PEPD6
AccessioniPrimary (citable) accession number: Q18AL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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