Reviewed, UniProtKB/Swiss-Prot Q18A79 (GLGA_CLOD6)

Names and origin

Protein names

Recommended name:
    Glycogen synthase
    EC=2.4.1.21
Alternative name(s):
    Starch [bacterial glycogen] synthase

Gene names

Name:	glgA
Ordered Locus Names:	CD0884

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Synthesizes alpha-1,4-glucan chains using ADP-glucose. HAMAP MF_00484
Catalytic activity	ADP-glucose + (1,4-alpha-D-glucosyl)(n) = ADP + (1,4-alpha-D-glucosyl)(n+1). HAMAP MF_00484
Pathway	Glycan biosynthesis; glycogen biosynthesis. HAMAP MF_00484
Sequence similarities	Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycogen biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	starch synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Glycogen synthase HAMAP MF_00484		PRO_1000014347
Sites
	Binding site	15	1	ADP-glucose By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q18A79-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 29980A176CDC0960	FASTA	480	55,524
	10 20 30 40 50 60 MKVFYVTAEC WPFAKTGGLG DVSYALPKEL KKEGVDVRVI MPKYSTIPSY LKDQLKEIAV 70 80 90 100 110 120 FSVRVGWRNQ YCGLLEMELD GVKFYFIDNE FYFRREDERK SIYGYGDDAE RYTFFTDAVL 130 140 150 160 170 180 EAISRIDFYP DVIHINDWHT GMLPLILKER YATLEGYKNI KTMYTIHNLQ YQGVFDKHVL 190 200 210 220 230 240 YDILDLPQKY FDNGDIEYYG SINFMKAGIN FADKIITVSP TYANEIQTSF YGEQLDGLLR 250 260 270 280 290 300 KESGKLKGIL NGIDYDLNDP AKDKDIFVHY DVDSINKKVE NKLRLQDILG LKKDSSIPLI 310 320 330 340 350 360 GIVSRLVSQK GFDLIAYMMP ELMREDLQIV VLGTGEHQYQ SMFNYYDSNF SDKVSARITF 370 380 390 400 410 420 NASLAQQIYA ASDMFLMPSL FEPCGIGQML AMRYGSLPIV RETGGLRDTV TPYNKFTGEG 430 440 450 460 470 480 NGFSFKNYNA HEMFFCLKNA IKVFKDKEKW IKLVENAMKT DNSWKKSAKE YIETYRDICD

References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome." Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T. , Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J. Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM180355 Genomic DNA. Translation: CAJ67717.1.
RefSeq	YP_001087358.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q18A79.
Protein family/group databases
CAZy	GT5. Glycosyltransferase Family 5.
Genome annotation databases
GeneID	4913419.
GenomeReviews	Gene locus CD0884 in contig AM180355_GR.
KEGG	cdf:CD0884.
NMPDR	fig|1496.1.peg.1760.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q18A79.
OMA	YQGPWRW.
Family and domain databases
HAMAP	MF_00484. [Tree]
InterPro	IPR011835. GlgA. IPR001296. Glyco_trans_1. IPR013534. Glyco_transf_5. [Graphical view]
Pfam	PF08323. Glyco_transf_5. 1 hit. PF00534. Glycos_transf_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR02095. glgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLGA_CLOD6

Accession

Primary (citable) accession number: Q18A79

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 25, 2006
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)