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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99Alpha-D-glucose 1-phosphateUniRule annotation1
Binding sitei164Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei190Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-990-MONOMER.
UniPathwayiUPA00164.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:CD630_08820
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002618611 – 386Glucose-1-phosphate adenylyltransferaseAdd BLAST386

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD0882.

Structurei

3D structure databases

ProteinModelPortaliQ18A75.
SMRiQ18A75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 180Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CNB. Bacteria.
COG0448. LUCA.
HOGENOMiHOG000278603.
KOiK00975.
OMAiHCVLGVR.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00624. GlgC. 1 hit.
InterProiView protein in InterPro
IPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR023049. GlgC_bac.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
PfamiView protein in Pfam
PF00483. NTP_transferase. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiView protein in PROSITE
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18A75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEMLAMIL AGGQGSRLGV FTKRIAKPAV SFGGKYRIID FVLSNCSNSG
60 70 80 90 100
IDTVGVLTQY RPLILNSHIG MGSHWDLDRI NGGVYVLQPF MNEKEGNWYN
110 120 130 140 150
GTAHAIYQNM DFVDTYNPEY VLILSGDHIY KMDYSKMLKF HKEKGSKATI
160 170 180 190 200
AVIEVPWDEA SRFGIMNTNE DSSIYEFEEK PSEPKSNLAS MGVYIFDWKM
210 220 230 240 250
LRNYFKEAEK NPEINYDDFG KNLIPKMLED NVGMYAYPFK GYWRDVGTIQ
260 270 280 290 300
SLWDANMDII KSPETLDLAD PKWKIYTNTM AMPPQYIGKN ANVHRSMIAD
310 320 330 340 350
GCRILGEVGN SVLSHGVVVG KGSKVIDSVI MPNVVIGENV TIEKAMIGEC
360 370 380
ATINDNVQIK NVNNEINVVS EYENIEPRCV LIEGGL
Length:386
Mass (Da):43,412
Last modified:July 25, 2006 - v1
Checksum:i63D855CD3D69F938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67715.1.
RefSeqiWP_003418638.1. NC_009089.1.
YP_001087356.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67715; CAJ67715; CD630_08820.
GeneIDi31352440.
4913417.
KEGGicdf:CD630_08820.
pdc:CDIF630_01002.
PATRICifig|272563.120.peg.906.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLGC_PEPD6
AccessioniPrimary (citable) accession number: Q18A75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 25, 2006
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families