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Q189R2

- FTHS_PEPD6

UniProt

Q189R2 - FTHS_PEPD6

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-855-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CD630_07180
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300518Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD0718.

Structurei

3D structure databases

ProteinModelPortaliQ189R2.
SMRiQ189R2. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q189R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFKSDIEIA QEAKPQDIRE VAKKLGLGED DVELYGKYKA KVDYNLLKRE
60 70 80 90 100
TGKKAKLILT TAINPTPAGE GKTTTTIGVA DAFAKLDKNV LVALREPSLG
110 120 130 140 150
PVFGVKGGAA GGGYAQVVPM EDINLHFTGD FHAIGAANNL LAAMLDNHIH
160 170 180 190 200
QGNALRIDPK KITWRRCVDM NDRQLRNIVD GMGKKGDGAV RQDGFDITVA
210 220 230 240 250
SEIMAAFCLA SDISDLKERL GNIIVGYSYE GEPVTARQLK ANGAMAALLK
260 270 280 290 300
DALKPNLVQT LEGTPSFVHG GPFANIAHGC NSVIATRMAM HFADYVITEA
310 320 330 340 350
GFGADLGAEK FLDIKCRMAN LKPDAVIIVA TVRALKYNGG VAKADLNNEN
360 370 380 390 400
LEALEKGLPN LLKHVENITQ VYGLPAVVAI NRFPLDTEAE LKLVEDKCKE
410 420 430 440 450
LGVNVALSEV WAKGGEGGIA VAKEVLRLLD EEENNFRFCY EDDLSIKDKI
460 470 480 490 500
NAIATKIYGA DGVDYTPEAD KEIANLEKLG FTKVPVCMAK TQYSLTDDQT
510 520 530 540 550
KLGRPTGFRI TVRQATISAG AGFIVALTGE IMKMPGLPKV PAAEKIDVDE

NGVIAGLF
Length:558
Mass (Da):59,986
Last modified:July 25, 2006 - v1
Checksum:i9BEE9D0D5B83FE61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67552.1.
RefSeqiYP_001087195.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67552; CAJ67552; CD630_07180.
GeneIDi4916827.
KEGGicdf:CD630_07180.
PATRICi19439723. VBICloDif38397_0755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67552.1 .
RefSeqi YP_001087195.1. NC_009089.1.

3D structure databases

ProteinModelPortali Q189R2.
SMRi Q189R2. Positions 6-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD0718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ67552 ; CAJ67552 ; CD630_07180 .
GeneIDi 4916827.
KEGGi cdf:CD630_07180.
PATRICi 19439723. VBICloDif38397_0755.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CDIF272563:GJFE-855-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiFTHS_PEPD6
AccessioniPrimary (citable) accession number: Q189R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 25, 2006
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3