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Q189R2

- FTHS_PEPD6

UniProt

Q189R2 - FTHS_PEPD6

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCDIF272563:GJFE-855-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CD630_07180
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300518Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272563.CD0718.

    Structurei

    3D structure databases

    ProteinModelPortaliQ189R2.
    SMRiQ189R2. Positions 6-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q189R2-1 [UniParc]FASTAAdd to Basket

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    MGFKSDIEIA QEAKPQDIRE VAKKLGLGED DVELYGKYKA KVDYNLLKRE    50
    TGKKAKLILT TAINPTPAGE GKTTTTIGVA DAFAKLDKNV LVALREPSLG 100
    PVFGVKGGAA GGGYAQVVPM EDINLHFTGD FHAIGAANNL LAAMLDNHIH 150
    QGNALRIDPK KITWRRCVDM NDRQLRNIVD GMGKKGDGAV RQDGFDITVA 200
    SEIMAAFCLA SDISDLKERL GNIIVGYSYE GEPVTARQLK ANGAMAALLK 250
    DALKPNLVQT LEGTPSFVHG GPFANIAHGC NSVIATRMAM HFADYVITEA 300
    GFGADLGAEK FLDIKCRMAN LKPDAVIIVA TVRALKYNGG VAKADLNNEN 350
    LEALEKGLPN LLKHVENITQ VYGLPAVVAI NRFPLDTEAE LKLVEDKCKE 400
    LGVNVALSEV WAKGGEGGIA VAKEVLRLLD EEENNFRFCY EDDLSIKDKI 450
    NAIATKIYGA DGVDYTPEAD KEIANLEKLG FTKVPVCMAK TQYSLTDDQT 500
    KLGRPTGFRI TVRQATISAG AGFIVALTGE IMKMPGLPKV PAAEKIDVDE 550
    NGVIAGLF 558
    Length:558
    Mass (Da):59,986
    Last modified:July 25, 2006 - v1
    Checksum:i9BEE9D0D5B83FE61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ67552.1.
    RefSeqiYP_001087195.1. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ67552; CAJ67552; CD630_07180.
    GeneIDi4916827.
    KEGGicdf:CD630_07180.
    PATRICi19439723. VBICloDif38397_0755.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ67552.1 .
    RefSeqi YP_001087195.1. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q189R2.
    SMRi Q189R2. Positions 6-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272563.CD0718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ67552 ; CAJ67552 ; CD630_07180 .
    GeneIDi 4916827.
    KEGGi cdf:CD630_07180.
    PATRICi 19439723. VBICloDif38397_0755.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CDIF272563:GJFE-855-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630.

    Entry informationi

    Entry nameiFTHS_PEPD6
    AccessioniPrimary (citable) accession number: Q189R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3