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Q189R2 (FTHS_PEPD6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:CD630_07180
OrganismPeptoclostridium difficile (strain 630) (Clostridium difficile) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300518

Regions

Nucleotide binding66 – 738ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q189R2 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 9BEE9D0D5B83FE61

FASTA55859,986
        10         20         30         40         50         60 
MGFKSDIEIA QEAKPQDIRE VAKKLGLGED DVELYGKYKA KVDYNLLKRE TGKKAKLILT 

        70         80         90        100        110        120 
TAINPTPAGE GKTTTTIGVA DAFAKLDKNV LVALREPSLG PVFGVKGGAA GGGYAQVVPM 

       130        140        150        160        170        180 
EDINLHFTGD FHAIGAANNL LAAMLDNHIH QGNALRIDPK KITWRRCVDM NDRQLRNIVD 

       190        200        210        220        230        240 
GMGKKGDGAV RQDGFDITVA SEIMAAFCLA SDISDLKERL GNIIVGYSYE GEPVTARQLK 

       250        260        270        280        290        300 
ANGAMAALLK DALKPNLVQT LEGTPSFVHG GPFANIAHGC NSVIATRMAM HFADYVITEA 

       310        320        330        340        350        360 
GFGADLGAEK FLDIKCRMAN LKPDAVIIVA TVRALKYNGG VAKADLNNEN LEALEKGLPN 

       370        380        390        400        410        420 
LLKHVENITQ VYGLPAVVAI NRFPLDTEAE LKLVEDKCKE LGVNVALSEV WAKGGEGGIA 

       430        440        450        460        470        480 
VAKEVLRLLD EEENNFRFCY EDDLSIKDKI NAIATKIYGA DGVDYTPEAD KEIANLEKLG 

       490        500        510        520        530        540 
FTKVPVCMAK TQYSLTDDQT KLGRPTGFRI TVRQATISAG AGFIVALTGE IMKMPGLPKV 

       550 
PAAEKIDVDE NGVIAGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ67552.1.
RefSeqYP_001087195.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ189R2.
SMRQ189R2. Positions 6-556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD0718.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ67552; CAJ67552; CD630_07180.
GeneID4916827.
KEGGcdf:CD630_07180.
PATRIC19439723. VBICloDif38397_0755.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-855-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PEPD6
AccessionPrimary (citable) accession number: Q189R2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways