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Q189Q7 (SYR_PEPD6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:CD630_07110
OrganismPeptoclostridium difficile (strain 630) (Clostridium difficile) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000198887

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q189Q7 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 767922C7C06F0B64

FASTA56664,990
        10         20         30         40         50         60 
MQDFKVAISN CLKEKIEDLS KEEIEALIEV PPNKDMGDYA FPCFKLAKVF RKAPNMIASE 

        70         80         90        100        110        120 
LAESIEPSGE ITKVIQLGGY VNFFVNKSQL AETVIKKVLD EKENYGHSDF GKDKTVIVEY 

       130        140        150        160        170        180 
SSPNIAKPFH IGHIRTTVIG NALYKIYDSQ GYKTIRINHL GDYGTQFGKL IVAFKKWGEK 

       190        200        210        220        230        240 
EVVESNPIPE LLKLYVRFHD EAEQHPEMED EARAWFNKLE NGDEEAQELW QWFRNESLKE 

       250        260        270        280        290        300 
FNRVYKLLDI EFDSLAGESF YSDKMNRVIE LLEEKNLLKE SKGARIVDLE EYKMPPALIT 

       310        320        330        340        350        360 
KNDGSTLYMT RDLAAAIYRK ETYDFDKCIY VVGSQQNLHF QQWFKVIELM GYDWAKDLIH 

       370        380        390        400        410        420 
VGFGMVALEE GTMSTRKGRV VFLEDALNQA IDKTKEIILA KNPNAKNVDE ISKQVGVGAV 

       430        440        450        460        470        480 
VFQELSNSRI KDYTFSWERT LSFDGETGPY VQYTHARCCA VLRKAEVEVT SDIDYSLLAD 

       490        500        510        520        530        540 
EDSAEVLRVI ESFNKNILLA LKKNEPHIVT RFMLDLAQAF NKFYHDNPIL VENLEIRKAR 

       550        560 
LALVLATKQT LENSLKLLGM HAPERM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ67544.1.
RefSeqYP_001087187.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ189Q7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD0711.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ67544; CAJ67544; CD630_07110.
GeneID4916819.
KEGGcdf:CD630_07110.
PATRIC19439705. VBICloDif38397_0746.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247211.
KOK01887.
OMAYVKFHDE.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-847-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_PEPD6
AccessionPrimary (citable) accession number: Q189Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries