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Q189P4

- Q189P4_PEPD6

UniProt

Q189P4 - Q189P4_PEPD6

Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per tetramer.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi254 – 2541MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: InterPro

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
    Gene namesi
    Name:pheSUniRule annotationImported
    Ordered Locus Names:CD630_06990Imported
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi272563.CD0699.

    Structurei

    3D structure databases

    ProteinModelPortaliQ189P4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0016.
    HOGENOMiHOG000242675.
    KOiK01889.
    OrthoDBiEOG6WX4QN.

    Family and domain databases

    HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view]
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00468. pheS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q189P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEKLLALRE AALAEIKEAQ SIESVESLRV KYLGKKGEIT AILKEMGKLS    50
    AEERPVVGKV ANEVRENIEL SINSKKEEIN AIEKERKLKE EVIDVTQPGK 100
    VLKVGKKHPI TQIIDEVTDI FIGMGFSIAE GPEVETVENN FDALNAPKDH 150
    PSRDMSDTFY INDGVLLRTQ TSPVQVRTMR SQELPIKVIA PGRCFRSDSP 200
    DATHSPMFHQ IEGLVVGKDV TMAEFKGTMD IFVEKLFGSD IKTKFRPHNF 250
    PFTEPSAEVD VTCFKCGGKG CPMCKYEGWI EILGSGMVHP NVLRNCGIDP 300
    EVYSGFAFGV GVERLAMLKY EIDDIRLLFE NDMRFLNQF 339
    Length:339
    Mass (Da):38,004
    Last modified:June 28, 2011 - v2
    Checksum:i16B501BEA3EE3C32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ67532.2.
    RefSeqiYP_001087175.2. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ67532; CAJ67532; CD630_06990.
    GeneIDi4916807.
    KEGGicdf:CD630_06990.
    PATRICi19439681. VBICloDif38397_0734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ67532.2 .
    RefSeqi YP_001087175.2. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q189P4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272563.CD0699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ67532 ; CAJ67532 ; CD630_06990 .
    GeneIDi 4916807.
    KEGGi cdf:CD630_06990.
    PATRICi 19439681. VBICloDif38397_0734.

    Phylogenomic databases

    eggNOGi COG0016.
    HOGENOMi HOG000242675.
    KOi K01889.
    OrthoDBi EOG6WX4QN.

    Family and domain databases

    HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00468. pheS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630Imported.

    Entry informationi

    Entry nameiQ189P4_PEPD6
    AccessioniPrimary (citable) accession number: Q189P4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 25, 2006
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3