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Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi254MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-809-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
Short name:
PheRSUniRule annotation
Gene namesi
Name:pheSUniRule annotationImported
Ordered Locus Names:CD630_06990Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi272563.CD0699

Structurei

3D structure databases

ProteinModelPortaliQ189P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 330AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 92Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CSS Bacteria
COG0016 LUCA
HOGENOMiHOG000242675
KOiK01889
OMAiDWHNFTA

Family and domain databases

HAMAPiMF_00281 Phe_tRNA_synth_alpha1, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004529 Phe-tRNA-synth_IIc_asu
IPR004188 Phe-tRNA_ligase_II_N
IPR022911 Phe_tRNA_ligase_alpha1_bac
IPR002319 Phenylalanyl-tRNA_Synthase
IPR010978 tRNA-bd_arm
PANTHERiPTHR11538:SF48 PTHR11538:SF48, 1 hit
PfamiView protein in Pfam
PF02912 Phe_tRNA-synt_N, 1 hit
PF01409 tRNA-synt_2d, 1 hit
SUPFAMiSSF46589 SSF46589, 1 hit
TIGRFAMsiTIGR00468 pheS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q189P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEKLLALRE AALAEIKEAQ SIESVESLRV KYLGKKGEIT AILKEMGKLS
60 70 80 90 100
AEERPVVGKV ANEVRENIEL SINSKKEEIN AIEKERKLKE EVIDVTQPGK
110 120 130 140 150
VLKVGKKHPI TQIIDEVTDI FIGMGFSIAE GPEVETVENN FDALNAPKDH
160 170 180 190 200
PSRDMSDTFY INDGVLLRTQ TSPVQVRTMR SQELPIKVIA PGRCFRSDSP
210 220 230 240 250
DATHSPMFHQ IEGLVVGKDV TMAEFKGTMD IFVEKLFGSD IKTKFRPHNF
260 270 280 290 300
PFTEPSAEVD VTCFKCGGKG CPMCKYEGWI EILGSGMVHP NVLRNCGIDP
310 320 330
EVYSGFAFGV GVERLAMLKY EIDDIRLLFE NDMRFLNQF
Length:339
Mass (Da):38,004
Last modified:June 28, 2011 - v2
Checksum:i16B501BEA3EE3C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ67532.2
RefSeqiWP_003436795.1, NZ_CP010905.2
YP_001087175.2, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ67532; CAJ67532; CD630_06990
GeneIDi31352257
4916807
KEGGicdf:CD630_06990
pdc:CDIF630_00814
PATRICifig|272563.120.peg.719

Similar proteinsi

Entry informationi

Entry nameiQ189P4_PEPD6
AccessioniPrimary (citable) accession number: Q189P4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: June 28, 2011
Last modified: January 31, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported