Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q189P4

- Q189P4_PEPD6

UniProt

Q189P4 - Q189P4_PEPD6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium ions per tetramer.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi254 – 2541MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunitUniRule annotationSAAS annotation (EC:6.1.1.20UniRule annotationSAAS annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
Gene namesi
Name:pheSUniRule annotationImported
Ordered Locus Names:CD630_06990Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi272563.CD0699.

Structurei

3D structure databases

ProteinModelPortaliQ189P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0016.
HOGENOMiHOG000242675.
KOiK01889.
OrthoDBiEOG6WX4QN.

Family and domain databases

HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view]
PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SUPFAMiSSF46589. SSF46589. 1 hit.
TIGRFAMsiTIGR00468. pheS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q189P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEKLLALRE AALAEIKEAQ SIESVESLRV KYLGKKGEIT AILKEMGKLS
60 70 80 90 100
AEERPVVGKV ANEVRENIEL SINSKKEEIN AIEKERKLKE EVIDVTQPGK
110 120 130 140 150
VLKVGKKHPI TQIIDEVTDI FIGMGFSIAE GPEVETVENN FDALNAPKDH
160 170 180 190 200
PSRDMSDTFY INDGVLLRTQ TSPVQVRTMR SQELPIKVIA PGRCFRSDSP
210 220 230 240 250
DATHSPMFHQ IEGLVVGKDV TMAEFKGTMD IFVEKLFGSD IKTKFRPHNF
260 270 280 290 300
PFTEPSAEVD VTCFKCGGKG CPMCKYEGWI EILGSGMVHP NVLRNCGIDP
310 320 330
EVYSGFAFGV GVERLAMLKY EIDDIRLLFE NDMRFLNQF
Length:339
Mass (Da):38,004
Last modified:June 28, 2011 - v2
Checksum:i16B501BEA3EE3C32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ67532.2.
RefSeqiYP_001087175.2. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67532; CAJ67532; CD630_06990.
GeneIDi4916807.
KEGGicdf:CD630_06990.
PATRICi19439681. VBICloDif38397_0734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ67532.2 .
RefSeqi YP_001087175.2. NC_009089.1.

3D structure databases

ProteinModelPortali Q189P4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD0699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ67532 ; CAJ67532 ; CD630_06990 .
GeneIDi 4916807.
KEGGi cdf:CD630_06990.
PATRICi 19439681. VBICloDif38397_0734.

Phylogenomic databases

eggNOGi COG0016.
HOGENOMi HOG000242675.
KOi K01889.
OrthoDBi EOG6WX4QN.

Family and domain databases

HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view ]
Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view ]
SUPFAMi SSF46589. SSF46589. 1 hit.
TIGRFAMsi TIGR00468. pheS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630Imported.

Entry informationi

Entry nameiQ189P4_PEPD6
AccessioniPrimary (citable) accession number: Q189P4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3