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Protein
Submitted name:

Toxin B

Gene

tcdB

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-794-MONOMER.
BRENDAi2.4.1.B62. 13625.

Protein family/group databases

CAZyiGT44. Glycosyltransferase Family 44.

Names & Taxonomyi

Protein namesi
Submitted name:
Toxin BImported (EC:2.4.1.-Imported)
Gene namesi
Name:tcdBImported
Ordered Locus Names:CD630_06600Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272563.CD0660.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PA8X-ray2.00A/B544-797[»]
3PEEX-ray2.10A/B544-797[»]
ProteinModelPortaliQ189K3.
SMRiQ189K3. Positions 1-541.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ189K3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini567 – 774208Peptidase C80InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4108N67. Bacteria.
COG5263. LUCA.
HOGENOMiHOG000122990.
KOiK11063.
OMAiDGFKYFA.
OrthoDBiEOG64V29F.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR020974. CPD_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR024770. TcdA/TcdB_cat.
IPR024772. TcdA/TcdB_N.
IPR024769. TcdA/TcdB_pore_forming.
[Graphical view]
PfamiPF01473. CW_binding_1. 4 hits.
PF11713. Peptidase_C80. 1 hit.
PF12919. TcdA_TcdB. 1 hit.
PF12920. TcdA_TcdB_pore. 1 hit.
PF12918. TcdB_N. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS51771. CGT_MARTX_CPD. 1 hit.
PS51170. CW. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q189K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVNRKQLE KMANVRFRTQ EDEYVAILDA LEEYHNMSEN TVVEKYLKLK
60 70 80 90 100
DINSLTDIYI DTYKKSGRNK ALKKFKEYLV TEVLELKNNN LTPVEKNLHF
110 120 130 140 150
VWIGGQINDT AINYINQWKD VNSDYNVNVF YDSNAFLINT LKKTVVESAI
160 170 180 190 200
NDTLESFREN LNDPRFDYNK FFRKRMEIIY DKQKNFINYY KAQREENPEL
210 220 230 240 250
IIDDIVKTYL SNEYSKEIDE LNTYIEESLN KITQNSGNDV RNFEEFKNGE
260 270 280 290 300
SFNLYEQELV ERWNLAAASD ILRISALKEI GGMYLDVDML PGIQPDLFES
310 320 330 340 350
IEKPSSVTVD FWEMTKLEAI MKYKEYIPEY TSEHFDMLDE EVQSSFESVL
360 370 380 390 400
ASKSDKSEIF SSLGDMEASP LEVKIAFNSK GIINQGLISV KDSYCSNLIV
410 420 430 440 450
KQIENRYKIL NNSLNPAISE DNDFNTTTNT FIDSIMAEAN ADNGRFMMEL
460 470 480 490 500
GKYLRVGFFP DVKTTINLSG PEAYAAAYQD LLMFKEGSMN IHLIEADLRN
510 520 530 540 550
FEISKTNISQ STEQEMASLW SFDDARAKAQ FEEYKRNYFE GSLGEDDNLD
560 570 580 590 600
FSQNIVVDKE YLLEKISSLA RSSERGYIHY IVQLQGDKIS YEAACNLFAK
610 620 630 640 650
TPYDSVLFQK NIEDSEIAYY YNPGDGEIQE IDKYKIPSII SDRPKIKLTF
660 670 680 690 700
IGHGKDEFNT DIFAGFDVDS LSTEIEAAID LAKEDISPKS IEINLLGCNM
710 720 730 740 750
FSYSINVEET YPGKLLLKVK DKISELMPSI SQDSIIVSAN QYEVRINSEG
760 770 780 790 800
RRELLDHSGE WINKEESIIK DISSKEYISF NPKENKITVK SKNLPELSTL
810 820 830 840 850
LQEIRNNSNS SDIELEEKVM LTECEINVIS NIDTQIVEER IEEAKNLTSD
860 870 880 890 900
SINYIKDEFK LIESISDALC DLKQQNELED SHFISFEDIS ETDEGFSIRF
910 920 930 940 950
INKETGESIF VETEKTIFSE YANHITEEIS KIKGTIFDTV NGKLVKKVNL
960 970 980 990 1000
DTTHEVNTLN AAFFIQSLIE YNSSKESLSN LSVAMKVQVY AQLFSTGLNT
1010 1020 1030 1040 1050
ITDAAKVVEL VSTALDETID LLPTLSEGLP IIATIIDGVS LGAAIKELSE
1060 1070 1080 1090 1100
TSDPLLRQEI EAKIGIMAVN LTTATTAIIT SSLGIASGFS ILLVPLAGIS
1110 1120 1130 1140 1150
AGIPSLVNNE LVLRDKATKV VDYFKHVSLV ETEGVFTLLD DKIMMPQDDL
1160 1170 1180 1190 1200
VISEIDFNNN SIVLGKCEIW RMEGGSGHTV TDDIDHFFSA PSITYREPHL
1210 1220 1230 1240 1250
SIYDVLEVQK EELDLSKDLM VLPNAPNRVF AWETGWTPGL RSLENDGTKL
1260 1270 1280 1290 1300
LDRIRDNYEG EFYWRYFAFI ADALITTLKP RYEDTNIRIN LDSNTRSFIV
1310 1320 1330 1340 1350
PIITTEYIRE KLSYSFYGSG GTYALSLSQY NMGINIELSE SDVWIIDVDN
1360 1370 1380 1390 1400
VVRDVTIESD KIKKGDLIEG ILSTLSIEEN KIILNSHEIN FSGEVNGSNG
1410 1420 1430 1440 1450
FVSLTFSILE GINAIIEVDL LSKSYKLLIS GELKILMLNS NHIQQKIDYI
1460 1470 1480 1490 1500
GFNSELQKNI PYSFVDSEGK ENGFINGSTK EGLFVSELPD VVLISKVYMD
1510 1520 1530 1540 1550
DSKPSFGYYS NNLKDVKVIT KDNVNILTGY YLKDDIKISL SLTLQDEKTI
1560 1570 1580 1590 1600
KLNSVHLDES GVAEILKFMN RKGNTNTSDS LMSFLESMNI KSIFVNFLQS
1610 1620 1630 1640 1650
NIKFILDANF IISGTTSIGQ FEFICDENDN IQPYFIKFNT LETNYTLYVG
1660 1670 1680 1690 1700
NRQNMIVEPN YDLDDSGDIS STVINFSQKY LYGIDSCVNK VVISPNIYTD
1710 1720 1730 1740 1750
EINITPVYET NNTYPEVIVL DANYINEKIN VNINDLSIRY VWSNDGNDFI
1760 1770 1780 1790 1800
LMSTSEENKV SQVKIRFVNV FKDKTLANKL SFNFSDKQDV PVSEIILSFT
1810 1820 1830 1840 1850
PSYYEDGLIG YDLGLVSLYN EKFYINNFGM MVSGLIYIND SLYYFKPPVN
1860 1870 1880 1890 1900
NLITGFVTVG DDKYYFNPIN GGAASIGETI IDDKNYYFNQ SGVLQTGVFS
1910 1920 1930 1940 1950
TEDGFKYFAP ANTLDENLEG EAIDFTGKLI IDENIYYFDD NYRGAVEWKE
1960 1970 1980 1990 2000
LDGEMHYFSP ETGKAFKGLN QIGDYKYYFN SDGVMQKGFV SINDNKHYFD
2010 2020 2030 2040 2050
DSGVMKVGYT EIDGKHFYFA ENGEMQIGVF NTEDGFKYFA HHNEDLGNEE
2060 2070 2080 2090 2100
GEEISYSGIL NFNNKIYYFD DSFTAVVGWK DLEDGSKYYF DEDTAEAYIG
2110 2120 2130 2140 2150
LSLINDGQYY FNDDGIMQVG FVTINDKVFY FSDSGIIESG VQNIDDNYFY
2160 2170 2180 2190 2200
IDDNGIVQIG VFDTSDGYKY FAPANTVNDN IYGQAVEYSG LVRVGEDVYY
2210 2220 2230 2240 2250
FGETYTIETG WIYDMENESD KYYFNPETKK ACKGINLIDD IKYYFDEKGI
2260 2270 2280 2290 2300
MRTGLISFEN NNYYFNENGE MQFGYINIED KMFYFGEDGV MQIGVFNTPD
2310 2320 2330 2340 2350
GFKYFAHQNT LDENFEGESI NYTGWLDLDE KRYYFTDEYI AATGSVIIDG
2360
EEYYFDPDTA QLVISE
Length:2,366
Mass (Da):269,712
Last modified:July 25, 2006 - v1
Checksum:iE1024BD8B8A56ADF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67492.1.
RefSeqiWP_009902069.1. NZ_CP010905.1.
YP_001087135.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67492; CAJ67492; CD630_06600.
GeneIDi4914074.
KEGGicdf:CD630_06600.
pdc:CDIF630_00773.
PATRICi19439601. VBICloDif38397_0694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67492.1.
RefSeqiWP_009902069.1. NZ_CP010905.1.
YP_001087135.1. NC_009089.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PA8X-ray2.00A/B544-797[»]
3PEEX-ray2.10A/B544-797[»]
ProteinModelPortaliQ189K3.
SMRiQ189K3. Positions 1-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD0660.

Protein family/group databases

CAZyiGT44. Glycosyltransferase Family 44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ67492; CAJ67492; CD630_06600.
GeneIDi4914074.
KEGGicdf:CD630_06600.
pdc:CDIF630_00773.
PATRICi19439601. VBICloDif38397_0694.

Phylogenomic databases

eggNOGiENOG4108N67. Bacteria.
COG5263. LUCA.
HOGENOMiHOG000122990.
KOiK11063.
OMAiDGFKYFA.
OrthoDBiEOG64V29F.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-794-MONOMER.
BRENDAi2.4.1.B62. 13625.

Miscellaneous databases

EvolutionaryTraceiQ189K3.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR020974. CPD_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR024770. TcdA/TcdB_cat.
IPR024772. TcdA/TcdB_N.
IPR024769. TcdA/TcdB_pore_forming.
[Graphical view]
PfamiPF01473. CW_binding_1. 4 hits.
PF11713. Peptidase_C80. 1 hit.
PF12919. TcdA_TcdB. 1 hit.
PF12920. TcdA_TcdB_pore. 1 hit.
PF12918. TcdB_N. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS51771. CGT_MARTX_CPD. 1 hit.
PS51170. CW. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630Imported.
  2. "Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB."
    Puri A.W., Lupardus P.J., Deu E., Albrow V.E., Garcia K.C., Bogyo M., Shen A.
    Chem. Biol. 17:1201-1211(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 544-797.
  3. "Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins."
    Shen A., Lupardus P.J., Gersch M.M., Puri A.W., Albrow V.E., Garcia K.C., Bogyo M.
    Nat. Struct. Mol. Biol. 18:364-371(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 544-797.

Entry informationi

Entry nameiQ189K3_PEPD6
AccessioniPrimary (citable) accession number: Q189K3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.