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Q18990

- Q18990_CAEEL

UniProt

Q18990 - Q18990_CAEEL

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Protein
Submitted name: Protein PYR-1
Gene
pyr-1, CELE_D2085.1, D2085.1
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. amino acid binding Source: InterPro
  3. aspartate carbamoyltransferase activity Source: InterPro
  4. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Source: InterPro
  5. metal ion binding Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. carbamoyl phosphate biosynthetic process Source: InterPro
  3. glutamine catabolic process Source: InterPro
  4. pharynx development Source: WormBase
  5. pyrimidine nucleobase biosynthetic process Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein PYR-1Imported
Gene namesi
Name:pyr-1Imported
ORF Names:CELE_D2085.1Imported, D2085.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiD2085.1; CE41886; WBGene00004259; pyr-1.

PTM / Processingi

Proteomic databases

PaxDbiQ18990.
PRIDEiQ18990.

Interactioni

Protein-protein interaction databases

STRINGi6239.D2085.1.

Structurei

3D structure databases

ProteinModelPortaliQ18990.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0458.
GeneTreeiENSGT00390000015604.
HOGENOMiHOG000234584.
InParanoidiQ18990.
KOiK11540.
OMAiYNQLRCF.
OrthoDBiEOG7M6D6F.
PhylomeDBiQ18990.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.1370. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPiMF_00001. Asp_carb_tr.
MF_01209. CPSase_S_chain.
InterProiIPR006680. Amidohydro_1.
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR029062. Class_I_gatase-like.
IPR002195. Dihydroorotase_CS.
IPR017926. GATASE.
IPR011059. Metal-dep_hydrolase_composite.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
PR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
SM01097. CPSase_sm_chain. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF51338. SSF51338. 1 hit.
SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
SSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00097. CARBAMOYLTRANSFERASE. 1 hit.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18990-1 [UniParc]FASTAAdd to Basket

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MRATLHLEDG STFVGSIYGA TKSVVGEIVF QTGMVGYVES LTDPSYAKQL     50
LTLTYPLIGN YGVPSAEILD QFKLPAEFES DRIWPAALIV EKICVDGEHS 100
HWQAVQSLSE WLRKADVPCL SGIDVRQLVK KIRETGTMKA KLVIESDNAQ 150
NFDYVDVNAE NLVDFVSRKE PVVYGSGDQT ILAVDCGLKN NQIRCLAKRG 200
FRVKVVPWNH PIDTESDYDG LFLSNGPGDP EICAPLVDRL AKVIARGDKP 250
IFGICLGHQI LSRAIGAKTY KLKYGNRGHN QPCTHYATGR CYITSQNHGY 300
AVDPDSLPAD WKALFTNEND KTNEGIVHSS KPFFSVQFHP EHTAGPTDCE 350
FLFDVFADSV RQAKSGTFMN VDQELTRLMT FTPIYHAKEQ RKVLVLGSGG 400
LTIGQAGEFD YSGAQALKAL REEGIRTVLI NPNIATVQTS KGFADFTYFL 450
PITKEYVTDV IKKERPTGIL CTFGGQTALN CAIDLYKDGI FEQYDVQVLG 500
TQINTIMKTE DRDLFNQEIS AIGEKVAPSK AATTMEGAIE AAEELGYPVL 550
VRAAYALGGL GSGFADNREE LIAIAQQALA HSNQVLVDKS LKGWKEVEYE 600
VVRDAYDNCI TVCNMENVDP LGIHTGESVV VAPSQTLSDR EYNALRTCAI 650
KVIRHLGIIG ECNIQYALDP YSLTYYIIEV NARLSRSSAL ASKATGYPLA 700
YVAAKLALGQ HLPVIRNSVT GTTTACFEPS LDYCVVKIPR WDLGKFARVS 750
TQIGSSMKSV GEVMGIGRCF EEALQKALRM VSDHADGFSP YTFSRPTTAD 800
DLSKPTDKRM FALARGMYYG DFDVEKAHEL TRIDRWFLFR MQNIVDIYHR 850
LEKTDVNTVS AELLLEAKQA GFSDRQIAKK IGSNEYTVRE ARFVKGITPC 900
VKQIDTVAGE WPAQTNYLYT TFNGIENDVS FNMKNAVMVL GSGVYRIGSS 950
VEFDSSCVGC IRELKALGYS TITVNCNPET VSTDYDICDR LYFEEISFET 1000
VLDVYHLEKP KGVILAFGGQ APNNIAMSLS RAQVKIFGTS PNDIDNAEDR 1050
FKFSRKLESL KISQPQWKKS ENMEDAKNFC AQVGYPCLIR PSYVLSGAAM 1100
NVAHNAEDLE VFLKQAAVVA KEHPVVVSKF INEAKELDVD AVALDGKLVV 1150
MAVSEHIENA GVHSGDATLV TPAQDMNKLT LDRIKDITFR IAEAFNVNGP 1200
FNMQLIAKNN ELKVIECNLR VSRSFPFVSK TLDYDFVALA TRAMMASDSP 1250
AIRATIKPTA TLLKGKGRVG VKVPQFSFSR LAGADVMLGV EMASTGEVAC 1300
FGTSRCDAYL KALLSTGFVV PKQNIFISIG GYHAKAEMLK SVEALLKLGY 1350
ELYGSKGTAD YFQSNKINVK PVDWPFEEGS SDEKTASGTR SVVEFLENKE 1400
FHLVINLPIR GSGAYRVSAF RTHGYKTRRM AIDNGIPLIT DIKCAKTFIQ 1450
ALEMVGKRPT MNSLVDCVTS KSLKRLPGMV DIHVHVREPG ATHKEDWATC 1500
SKAALAGGVT TILAMPNTSP VLVDTDSFYQ TEQLASAKSV VDYALYIGAT 1550
PNNSKFAAEF ADKAAGLKMY LNETFSTLKM DNISDWAKHL SAFPANRPIV 1600
CHAEKQTLAA ILCMAQMANR AVHIAHVATA DEINLVKEAK QRGWNVTCEV 1650
CPHHLFLIEE DLPDGIREVR PRLVKPEDRQ ALWDNMEYID CFATDHAPHT 1700
WAEKTGKDGK IPPGFPGVEY MLPLLLTAVH DGKLTMKELT DRMSTNPRRI 1750
FNLPPQDDTY IEVDLNEEWT IPENGGQSKA GWTPFAGRKV FGKVHNVIIR 1800
GEEAVIDGRI VAIPGFGKNV RLYPHSGTAH RGDSDFDQIL EPIPQQMIES 1850
SSDEQSPLHT PPRAHTPIAF PGELLAKNCI SVKHLDKGQI NRIFELADRY 1900
KHDVEKGHPL THILNGKVLV NLFYEVSTRT SCSFSAAMQR LGGSVISVDS 1950
QSSSVQKGET LEDTVQVLGS YGDILVLRSN ENGAADRAAR VCDQPVINGG 2000
DGTGEHPTQA LLDVYTIRQE MGTVNGLTIA LVGDLKNGRT VHSLAKLLCL 2050
YKDITLHYVA PSTELEMPQE VLDYVSSKSN FVQKKFTSLA EGINHVDVVY 2100
VTRIQKERFS SPDEYNKVKG SYVINAKLLN EAARDVEEPS SLLVPARSLP 2150
IVMHPLPRVD EIAVELDHDE RAAYFRQAKN GVFVRMSILS LLLGRGHL 2198
Length:2,198
Mass (Da):242,582
Last modified:February 5, 2008 - v2
Checksum:i31CFC62E64D21B1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54284 Genomic DNA. Translation: CAA91059.2.
RefSeqiNP_495838.2. NM_063437.4.
UniGeneiCel.33265.

Genome annotation databases

EnsemblMetazoaiD2085.1; D2085.1; WBGene00004259.
GeneIDi174385.
KEGGicel:CELE_D2085.1.
UCSCiD2085.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54284 Genomic DNA. Translation: CAA91059.2 .
RefSeqi NP_495838.2. NM_063437.4.
UniGenei Cel.33265.

3D structure databases

ProteinModelPortali Q18990.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.D2085.1.

Proteomic databases

PaxDbi Q18990.
PRIDEi Q18990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai D2085.1 ; D2085.1 ; WBGene00004259 .
GeneIDi 174385.
KEGGi cel:CELE_D2085.1.
UCSCi D2085.1. c. elegans.

Organism-specific databases

CTDi 174385.
WormBasei D2085.1 ; CE41886 ; WBGene00004259 ; pyr-1.

Phylogenomic databases

eggNOGi COG0458.
GeneTreei ENSGT00390000015604.
HOGENOMi HOG000234584.
InParanoidi Q18990.
KOi K11540.
OMAi YNQLRCF.
OrthoDBi EOG7M6D6F.
PhylomeDBi Q18990.

Miscellaneous databases

NextBioi 883806.

Family and domain databases

Gene3Di 1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.1370. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPi MF_00001. Asp_carb_tr.
MF_01209. CPSase_S_chain.
InterProi IPR006680. Amidohydro_1.
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR029062. Class_I_gatase-like.
IPR002195. Dihydroorotase_CS.
IPR017926. GATASE.
IPR011059. Metal-dep_hydrolase_composite.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00101. ATCASE.
PR00098. CPSASE.
SMARTi SM01096. CPSase_L_D3. 1 hit.
SM01097. CPSase_sm_chain. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48108. SSF48108. 1 hit.
SSF51338. SSF51338. 1 hit.
SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00670. asp_carb_tr. 1 hit.
TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEi PS50975. ATP_GRASP. 2 hits.
PS00097. CARBAMOYLTRANSFERASE. 1 hit.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiQ18990_CAEEL
AccessioniPrimary (citable) accession number: Q18990
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi