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Q18990

- Q18990_CAEEL

UniProt

Q18990 - Q18990_CAEEL

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Protein
Submitted name:

Protein PYR-1

Gene

pyr-1

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. aspartate carbamoyltransferase activity Source: InterPro
  3. ATP binding Source: InterPro
  4. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Source: InterPro
  5. metal ion binding Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. carbamoyl phosphate biosynthetic process Source: InterPro
  3. glutamine catabolic process Source: InterPro
  4. pharynx development Source: WormBase
  5. pyrimidine nucleobase biosynthetic process Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein PYR-1Imported
Gene namesi
Name:pyr-1Imported
ORF Names:CELE_D2085.1Imported, D2085.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiD2085.1; CE41886; WBGene00004259; pyr-1.

PTM / Processingi

Proteomic databases

PaxDbiQ18990.
PRIDEiQ18990.

Interactioni

Protein-protein interaction databases

STRINGi6239.D2085.1.

Structurei

3D structure databases

ProteinModelPortaliQ18990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0458.
GeneTreeiENSGT00390000015604.
HOGENOMiHOG000234584.
InParanoidiQ18990.
KOiK11540.
OMAiYNQLRCF.
OrthoDBiEOG7M6D6F.
PhylomeDBiQ18990.

Family and domain databases

Gene3Di1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.1370. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPiMF_00001. Asp_carb_tr.
MF_01209. CPSase_S_chain.
InterProiIPR006680. Amidohydro_1.
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR029062. Class_I_gatase-like.
IPR002195. Dihydroorotase_CS.
IPR017926. GATASE.
IPR011059. Metal-dep_hydrolase_composite.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00101. ATCASE.
PR00098. CPSASE.
SMARTiSM01096. CPSase_L_D3. 1 hit.
SM01097. CPSase_sm_chain. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF48108. SSF48108. 1 hit.
SSF51338. SSF51338. 1 hit.
SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
SSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00670. asp_carb_tr. 1 hit.
TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEiPS50975. ATP_GRASP. 2 hits.
PS00097. CARBAMOYLTRANSFERASE. 1 hit.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18990-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRATLHLEDG STFVGSIYGA TKSVVGEIVF QTGMVGYVES LTDPSYAKQL
60 70 80 90 100
LTLTYPLIGN YGVPSAEILD QFKLPAEFES DRIWPAALIV EKICVDGEHS
110 120 130 140 150
HWQAVQSLSE WLRKADVPCL SGIDVRQLVK KIRETGTMKA KLVIESDNAQ
160 170 180 190 200
NFDYVDVNAE NLVDFVSRKE PVVYGSGDQT ILAVDCGLKN NQIRCLAKRG
210 220 230 240 250
FRVKVVPWNH PIDTESDYDG LFLSNGPGDP EICAPLVDRL AKVIARGDKP
260 270 280 290 300
IFGICLGHQI LSRAIGAKTY KLKYGNRGHN QPCTHYATGR CYITSQNHGY
310 320 330 340 350
AVDPDSLPAD WKALFTNEND KTNEGIVHSS KPFFSVQFHP EHTAGPTDCE
360 370 380 390 400
FLFDVFADSV RQAKSGTFMN VDQELTRLMT FTPIYHAKEQ RKVLVLGSGG
410 420 430 440 450
LTIGQAGEFD YSGAQALKAL REEGIRTVLI NPNIATVQTS KGFADFTYFL
460 470 480 490 500
PITKEYVTDV IKKERPTGIL CTFGGQTALN CAIDLYKDGI FEQYDVQVLG
510 520 530 540 550
TQINTIMKTE DRDLFNQEIS AIGEKVAPSK AATTMEGAIE AAEELGYPVL
560 570 580 590 600
VRAAYALGGL GSGFADNREE LIAIAQQALA HSNQVLVDKS LKGWKEVEYE
610 620 630 640 650
VVRDAYDNCI TVCNMENVDP LGIHTGESVV VAPSQTLSDR EYNALRTCAI
660 670 680 690 700
KVIRHLGIIG ECNIQYALDP YSLTYYIIEV NARLSRSSAL ASKATGYPLA
710 720 730 740 750
YVAAKLALGQ HLPVIRNSVT GTTTACFEPS LDYCVVKIPR WDLGKFARVS
760 770 780 790 800
TQIGSSMKSV GEVMGIGRCF EEALQKALRM VSDHADGFSP YTFSRPTTAD
810 820 830 840 850
DLSKPTDKRM FALARGMYYG DFDVEKAHEL TRIDRWFLFR MQNIVDIYHR
860 870 880 890 900
LEKTDVNTVS AELLLEAKQA GFSDRQIAKK IGSNEYTVRE ARFVKGITPC
910 920 930 940 950
VKQIDTVAGE WPAQTNYLYT TFNGIENDVS FNMKNAVMVL GSGVYRIGSS
960 970 980 990 1000
VEFDSSCVGC IRELKALGYS TITVNCNPET VSTDYDICDR LYFEEISFET
1010 1020 1030 1040 1050
VLDVYHLEKP KGVILAFGGQ APNNIAMSLS RAQVKIFGTS PNDIDNAEDR
1060 1070 1080 1090 1100
FKFSRKLESL KISQPQWKKS ENMEDAKNFC AQVGYPCLIR PSYVLSGAAM
1110 1120 1130 1140 1150
NVAHNAEDLE VFLKQAAVVA KEHPVVVSKF INEAKELDVD AVALDGKLVV
1160 1170 1180 1190 1200
MAVSEHIENA GVHSGDATLV TPAQDMNKLT LDRIKDITFR IAEAFNVNGP
1210 1220 1230 1240 1250
FNMQLIAKNN ELKVIECNLR VSRSFPFVSK TLDYDFVALA TRAMMASDSP
1260 1270 1280 1290 1300
AIRATIKPTA TLLKGKGRVG VKVPQFSFSR LAGADVMLGV EMASTGEVAC
1310 1320 1330 1340 1350
FGTSRCDAYL KALLSTGFVV PKQNIFISIG GYHAKAEMLK SVEALLKLGY
1360 1370 1380 1390 1400
ELYGSKGTAD YFQSNKINVK PVDWPFEEGS SDEKTASGTR SVVEFLENKE
1410 1420 1430 1440 1450
FHLVINLPIR GSGAYRVSAF RTHGYKTRRM AIDNGIPLIT DIKCAKTFIQ
1460 1470 1480 1490 1500
ALEMVGKRPT MNSLVDCVTS KSLKRLPGMV DIHVHVREPG ATHKEDWATC
1510 1520 1530 1540 1550
SKAALAGGVT TILAMPNTSP VLVDTDSFYQ TEQLASAKSV VDYALYIGAT
1560 1570 1580 1590 1600
PNNSKFAAEF ADKAAGLKMY LNETFSTLKM DNISDWAKHL SAFPANRPIV
1610 1620 1630 1640 1650
CHAEKQTLAA ILCMAQMANR AVHIAHVATA DEINLVKEAK QRGWNVTCEV
1660 1670 1680 1690 1700
CPHHLFLIEE DLPDGIREVR PRLVKPEDRQ ALWDNMEYID CFATDHAPHT
1710 1720 1730 1740 1750
WAEKTGKDGK IPPGFPGVEY MLPLLLTAVH DGKLTMKELT DRMSTNPRRI
1760 1770 1780 1790 1800
FNLPPQDDTY IEVDLNEEWT IPENGGQSKA GWTPFAGRKV FGKVHNVIIR
1810 1820 1830 1840 1850
GEEAVIDGRI VAIPGFGKNV RLYPHSGTAH RGDSDFDQIL EPIPQQMIES
1860 1870 1880 1890 1900
SSDEQSPLHT PPRAHTPIAF PGELLAKNCI SVKHLDKGQI NRIFELADRY
1910 1920 1930 1940 1950
KHDVEKGHPL THILNGKVLV NLFYEVSTRT SCSFSAAMQR LGGSVISVDS
1960 1970 1980 1990 2000
QSSSVQKGET LEDTVQVLGS YGDILVLRSN ENGAADRAAR VCDQPVINGG
2010 2020 2030 2040 2050
DGTGEHPTQA LLDVYTIRQE MGTVNGLTIA LVGDLKNGRT VHSLAKLLCL
2060 2070 2080 2090 2100
YKDITLHYVA PSTELEMPQE VLDYVSSKSN FVQKKFTSLA EGINHVDVVY
2110 2120 2130 2140 2150
VTRIQKERFS SPDEYNKVKG SYVINAKLLN EAARDVEEPS SLLVPARSLP
2160 2170 2180 2190
IVMHPLPRVD EIAVELDHDE RAAYFRQAKN GVFVRMSILS LLLGRGHL
Length:2,198
Mass (Da):242,582
Last modified:February 5, 2008 - v2
Checksum:i31CFC62E64D21B1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54284 Genomic DNA. Translation: CAA91059.2.
RefSeqiNP_495838.2. NM_063437.4.
UniGeneiCel.33265.

Genome annotation databases

EnsemblMetazoaiD2085.1; D2085.1; WBGene00004259.
GeneIDi174385.
KEGGicel:CELE_D2085.1.
UCSCiD2085.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z54284 Genomic DNA. Translation: CAA91059.2 .
RefSeqi NP_495838.2. NM_063437.4.
UniGenei Cel.33265.

3D structure databases

ProteinModelPortali Q18990.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.D2085.1.

Proteomic databases

PaxDbi Q18990.
PRIDEi Q18990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai D2085.1 ; D2085.1 ; WBGene00004259 .
GeneIDi 174385.
KEGGi cel:CELE_D2085.1.
UCSCi D2085.1. c. elegans.

Organism-specific databases

CTDi 174385.
WormBasei D2085.1 ; CE41886 ; WBGene00004259 ; pyr-1.

Phylogenomic databases

eggNOGi COG0458.
GeneTreei ENSGT00390000015604.
HOGENOMi HOG000234584.
InParanoidi Q18990.
KOi K11540.
OMAi YNQLRCF.
OrthoDBi EOG7M6D6F.
PhylomeDBi Q18990.

Miscellaneous databases

NextBioi 883806.

Family and domain databases

Gene3Di 1.10.1030.10. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.1370. 2 hits.
3.40.50.1380. 1 hit.
3.40.50.20. 2 hits.
3.40.50.880. 1 hit.
3.50.30.20. 1 hit.
HAMAPi MF_00001. Asp_carb_tr.
MF_01209. CPSase_S_chain.
InterProi IPR006680. Amidohydro_1.
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR002082. Asp_carbamoyltransf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006275. CarbamoylP_synth_lsu.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005480. CarbamoylP_synth_lsu_oligo.
IPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR005483. CbamoylP_synth_lsu_CPSase_dom.
IPR029062. Class_I_gatase-like.
IPR002195. Dihydroorotase_CS.
IPR017926. GATASE.
IPR011059. Metal-dep_hydrolase_composite.
IPR011607. MGS-like_dom.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
PF00289. CPSase_L_chain. 2 hits.
PF02786. CPSase_L_D2. 2 hits.
PF02787. CPSase_L_D3. 1 hit.
PF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
PF02142. MGS. 1 hit.
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00101. ATCASE.
PR00098. CPSASE.
SMARTi SM01096. CPSase_L_D3. 1 hit.
SM01097. CPSase_sm_chain. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48108. SSF48108. 1 hit.
SSF51338. SSF51338. 1 hit.
SSF52021. SSF52021. 1 hit.
SSF52317. SSF52317. 1 hit.
SSF52335. SSF52335. 1 hit.
SSF52440. SSF52440. 2 hits.
SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00670. asp_carb_tr. 1 hit.
TIGR01369. CPSaseII_lrg. 1 hit.
TIGR01368. CPSaseIIsmall. 1 hit.
PROSITEi PS50975. ATP_GRASP. 2 hits.
PS00097. CARBAMOYLTRANSFERASE. 1 hit.
PS00866. CPSASE_1. 2 hits.
PS00867. CPSASE_2. 2 hits.
PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ18990_CAEEL
AccessioniPrimary (citable) accession number: Q18990
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: February 5, 2008
Last modified: October 1, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3