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Q18973 (GSTK2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione s-transferase kappa 2

EC=2.5.1.18
Gene names
Name:gstk-2
ORF Names:D2024.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has roles in respiratory and lipid metabolism. Ref.2

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subcellular location

Mitochondrion Ref.2.

Tissue specificity

Expressed in the pharynx, body wall muscles and epidermis. Weaker expression is seen in the intestine. Ref.2

Disruption phenotype

Significant decrease in respiration rate and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid. Ref.2

Sequence similarities

Belongs to the GST superfamily. Kappa family.

Ontologies

Keywords
   Cellular componentMitochondrion
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from direct assay Ref.2. Source: WormBase

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

protein disulfide oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Glutathione s-transferase kappa 2
PRO_0000185894

Regions

Region15 – 173Glutathione binding By similarity
Region200 – 2012Glutathione binding By similarity

Sites

Binding site521Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q18973 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 23D0A3D6762B7232

FASTA22525,951
        10         20         30         40         50         60 
MPNRKVVKFF FDVISPYSYF GFEGITRHRS VWKTPIQMKP FFFAGVVRHT ENPGLPLRIP 

        70         80         90        100        110        120 
IKEKYMHKDL LFSAQYWGIP FRLPKDYTNM MLNTSSIVPQ RILVASQLRD NVLMEDVARG 

       130        140        150        160        170        180 
LWHRFYAYGK PIFTKSQVAE VLRDLHVKDV DELVMMSDSA EVKNILRENT DEAIGNGCFG 

       190        200        210        220 
APWMHITDGH GKVLQTVFGS DRLPQVADFL AEPFKGPMRE KKPNA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans."
Petit E., Michelet X., Rauch C., Bertrand-Michel J., Terce F., Legouis R., Morel F.
FEBS J. 276:5030-5040(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080386 Genomic DNA. Translation: CCD63360.1.
PIRT34201.
RefSeqNP_501148.1. NM_068747.4.
UniGeneCel.13215.

3D structure databases

ProteinModelPortalQ18973.
SMRQ18973. Positions 2-218.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ18973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaD2024.7.1; D2024.7.1; D2024.7.
D2024.7.2; D2024.7.2; D2024.7.
GeneID177498.
KEGGcel:CELE_D2024.7.

Organism-specific databases

CTD177498.
WormBaseD2024.7; CE04296; WBGene00017054; gstk-2.

Phylogenomic databases

eggNOGCOG3917.
HOGENOMHOG000018051.
InParanoidQ18973.
OMAVAWHPIL.
PhylomeDBQ18973.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMSSF52833. SSF52833. 1 hit.
ProtoNetSearch...

Other

NextBio897092.

Entry information

Entry nameGSTK2_CAEEL
AccessionPrimary (citable) accession number: Q18973
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase