Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q18973

- GSTK2_CAEEL

UniProt

Q18973 - GSTK2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutathione s-transferase kappa 2

Gene

gstk-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has roles in respiratory and lipid metabolism.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. protein disulfide oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione s-transferase kappa 2 (EC:2.5.1.18)
Gene namesi
Name:gstk-2
ORF Names:D2024.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiD2024.7; CE04296; WBGene00017054; gstk-2.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Significant decrease in respiration rate and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Glutathione s-transferase kappa 2PRO_0000185894Add
BLAST

Proteomic databases

PaxDbiQ18973.

Expressioni

Tissue specificityi

Expressed in the pharynx, body wall muscles and epidermis. Weaker expression is seen in the intestine.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ18973.
SMRiQ18973. Positions 2-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 173Glutathione bindingBy similarity
Regioni200 – 2012Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiCOG3917.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000018051.
InParanoidiQ18973.
OMAiIAEQSIK.
PhylomeDBiQ18973.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18973-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPNRKVVKFF FDVISPYSYF GFEGITRHRS VWKTPIQMKP FFFAGVVRHT
60 70 80 90 100
ENPGLPLRIP IKEKYMHKDL LFSAQYWGIP FRLPKDYTNM MLNTSSIVPQ
110 120 130 140 150
RILVASQLRD NVLMEDVARG LWHRFYAYGK PIFTKSQVAE VLRDLHVKDV
160 170 180 190 200
DELVMMSDSA EVKNILRENT DEAIGNGCFG APWMHITDGH GKVLQTVFGS
210 220
DRLPQVADFL AEPFKGPMRE KKPNA
Length:225
Mass (Da):25,951
Last modified:November 1, 1996 - v1
Checksum:i23D0A3D6762B7232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080386 Genomic DNA. Translation: CCD63360.1.
PIRiT34201.
RefSeqiNP_501148.1. NM_068747.4.
UniGeneiCel.13215.

Genome annotation databases

EnsemblMetazoaiD2024.7.1; D2024.7.1; WBGene00017054.
D2024.7.2; D2024.7.2; WBGene00017054.
GeneIDi177498.
KEGGicel:CELE_D2024.7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080386 Genomic DNA. Translation: CCD63360.1 .
PIRi T34201.
RefSeqi NP_501148.1. NM_068747.4.
UniGenei Cel.13215.

3D structure databases

ProteinModelPortali Q18973.
SMRi Q18973. Positions 2-218.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q18973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai D2024.7.1 ; D2024.7.1 ; WBGene00017054 .
D2024.7.2 ; D2024.7.2 ; WBGene00017054 .
GeneIDi 177498.
KEGGi cel:CELE_D2024.7.

Organism-specific databases

CTDi 177498.
WormBasei D2024.7 ; CE04296 ; WBGene00017054 ; gstk-2.

Phylogenomic databases

eggNOGi COG3917.
GeneTreei ENSGT00440000033697.
HOGENOMi HOG000018051.
InParanoidi Q18973.
OMAi IAEQSIK.
PhylomeDBi Q18973.

Miscellaneous databases

NextBioi 897092.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF01323. DSBA. 1 hit.
[Graphical view ]
PIRSFi PIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans."
    Petit E., Michelet X., Rauch C., Bertrand-Michel J., Terce F., Legouis R., Morel F.
    FEBS J. 276:5030-5040(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGSTK2_CAEEL
AccessioniPrimary (citable) accession number: Q18973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3