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Protein

Glutathione s-transferase kappa 2

Gene

gstk-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has roles in respiratory and lipid metabolism.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. protein disulfide oxidoreductase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione s-transferase kappa 2 (EC:2.5.1.18)
Gene namesi
Name:gstk-2
ORF Names:D2024.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiD2024.7; CE04296; WBGene00017054; gstk-2.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Significant decrease in respiration rate and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Glutathione s-transferase kappa 2PRO_0000185894Add
BLAST

Proteomic databases

PaxDbiQ18973.

Expressioni

Tissue specificityi

Expressed in the pharynx, body wall muscles and epidermis. Weaker expression is seen in the intestine.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ18973.
SMRiQ18973. Positions 2-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 173Glutathione bindingBy similarity
Regioni200 – 2012Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiCOG3917.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000018051.
InParanoidiQ18973.
OMAiVAWHPIL.
PhylomeDBiQ18973.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNRKVVKFF FDVISPYSYF GFEGITRHRS VWKTPIQMKP FFFAGVVRHT
60 70 80 90 100
ENPGLPLRIP IKEKYMHKDL LFSAQYWGIP FRLPKDYTNM MLNTSSIVPQ
110 120 130 140 150
RILVASQLRD NVLMEDVARG LWHRFYAYGK PIFTKSQVAE VLRDLHVKDV
160 170 180 190 200
DELVMMSDSA EVKNILRENT DEAIGNGCFG APWMHITDGH GKVLQTVFGS
210 220
DRLPQVADFL AEPFKGPMRE KKPNA
Length:225
Mass (Da):25,951
Last modified:November 1, 1996 - v1
Checksum:i23D0A3D6762B7232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080386 Genomic DNA. Translation: CCD63360.1.
PIRiT34201.
RefSeqiNP_501148.1. NM_068747.4.
UniGeneiCel.13215.

Genome annotation databases

EnsemblMetazoaiD2024.7.1; D2024.7.1; WBGene00017054.
D2024.7.2; D2024.7.2; WBGene00017054.
GeneIDi177498.
KEGGicel:CELE_D2024.7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080386 Genomic DNA. Translation: CCD63360.1.
PIRiT34201.
RefSeqiNP_501148.1. NM_068747.4.
UniGeneiCel.13215.

3D structure databases

ProteinModelPortaliQ18973.
SMRiQ18973. Positions 2-218.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ18973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiD2024.7.1; D2024.7.1; WBGene00017054.
D2024.7.2; D2024.7.2; WBGene00017054.
GeneIDi177498.
KEGGicel:CELE_D2024.7.

Organism-specific databases

CTDi177498.
WormBaseiD2024.7; CE04296; WBGene00017054; gstk-2.

Phylogenomic databases

eggNOGiCOG3917.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000018051.
InParanoidiQ18973.
OMAiVAWHPIL.
PhylomeDBiQ18973.

Miscellaneous databases

NextBioi897092.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01323. DSBA. 1 hit.
[Graphical view]
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans."
    Petit E., Michelet X., Rauch C., Bertrand-Michel J., Terce F., Legouis R., Morel F.
    FEBS J. 276:5030-5040(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGSTK2_CAEEL
AccessioniPrimary (citable) accession number: Q18973
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.