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Q18973

- GSTK2_CAEEL

UniProt

Q18973 - GSTK2_CAEEL

Protein

Glutathione s-transferase kappa 2

Gene

gstk-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Has roles in respiratory and lipid metabolism.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC
    2. protein disulfide oxidoreductase activity Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione s-transferase kappa 2 (EC:2.5.1.18)
    Gene namesi
    Name:gstk-2
    ORF Names:D2024.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiD2024.7; CE04296; WBGene00017054; gstk-2.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Disruption phenotypei

    Significant decrease in respiration rate and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Glutathione s-transferase kappa 2PRO_0000185894Add
    BLAST

    Proteomic databases

    PaxDbiQ18973.

    Expressioni

    Tissue specificityi

    Expressed in the pharynx, body wall muscles and epidermis. Weaker expression is seen in the intestine.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ18973.
    SMRiQ18973. Positions 2-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 173Glutathione bindingBy similarity
    Regioni200 – 2012Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Kappa family.Curated

    Phylogenomic databases

    eggNOGiCOG3917.
    GeneTreeiENSGT00440000033697.
    HOGENOMiHOG000018051.
    InParanoidiQ18973.
    OMAiIAEQSIK.
    PhylomeDBiQ18973.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR001853. DSBA-like_thioredoxin_dom.
    IPR014440. HCCAis_GSTk.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF01323. DSBA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q18973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPNRKVVKFF FDVISPYSYF GFEGITRHRS VWKTPIQMKP FFFAGVVRHT    50
    ENPGLPLRIP IKEKYMHKDL LFSAQYWGIP FRLPKDYTNM MLNTSSIVPQ 100
    RILVASQLRD NVLMEDVARG LWHRFYAYGK PIFTKSQVAE VLRDLHVKDV 150
    DELVMMSDSA EVKNILRENT DEAIGNGCFG APWMHITDGH GKVLQTVFGS 200
    DRLPQVADFL AEPFKGPMRE KKPNA 225
    Length:225
    Mass (Da):25,951
    Last modified:November 1, 1996 - v1
    Checksum:i23D0A3D6762B7232
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080386 Genomic DNA. Translation: CCD63360.1.
    PIRiT34201.
    RefSeqiNP_501148.1. NM_068747.4.
    UniGeneiCel.13215.

    Genome annotation databases

    EnsemblMetazoaiD2024.7.1; D2024.7.1; WBGene00017054.
    D2024.7.2; D2024.7.2; WBGene00017054.
    GeneIDi177498.
    KEGGicel:CELE_D2024.7.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080386 Genomic DNA. Translation: CCD63360.1 .
    PIRi T34201.
    RefSeqi NP_501148.1. NM_068747.4.
    UniGenei Cel.13215.

    3D structure databases

    ProteinModelPortali Q18973.
    SMRi Q18973. Positions 2-218.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q18973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai D2024.7.1 ; D2024.7.1 ; WBGene00017054 .
    D2024.7.2 ; D2024.7.2 ; WBGene00017054 .
    GeneIDi 177498.
    KEGGi cel:CELE_D2024.7.

    Organism-specific databases

    CTDi 177498.
    WormBasei D2024.7 ; CE04296 ; WBGene00017054 ; gstk-2.

    Phylogenomic databases

    eggNOGi COG3917.
    GeneTreei ENSGT00440000033697.
    HOGENOMi HOG000018051.
    InParanoidi Q18973.
    OMAi IAEQSIK.
    PhylomeDBi Q18973.

    Miscellaneous databases

    NextBioi 897092.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR001853. DSBA-like_thioredoxin_dom.
    IPR014440. HCCAis_GSTk.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF01323. DSBA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006386. HCCAis_GSTk. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans."
      Petit E., Michelet X., Rauch C., Bertrand-Michel J., Terce F., Legouis R., Morel F.
      FEBS J. 276:5030-5040(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiGSTK2_CAEEL
    AccessioniPrimary (citable) accession number: Q18973
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3