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Protein

Glutathione s-transferase kappa 2

Gene

gstk-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has roles in respiratory and lipid metabolism.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52GlutathioneBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione s-transferase kappa 2 (EC:2.5.1.18)
Gene namesi
Name:gstk-2
ORF Names:D2024.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiD2024.7 ; CE04296 ; WBGene00017054 ; gstk-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Significant decrease in respiration rate and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858941 – 225Glutathione s-transferase kappa 2Add BLAST225

Proteomic databases

EPDiQ18973
PaxDbiQ18973
PeptideAtlasiQ18973
PRIDEiQ18973

Expressioni

Tissue specificityi

Expressed in the pharynx, body wall muscles and epidermis. Weaker expression is seen in the intestine.1 Publication

Gene expression databases

BgeeiWBGene00017054

Interactioni

Protein-protein interaction databases

STRINGi6239.D2024.7.1

Structurei

3D structure databases

ProteinModelPortaliQ18973
SMRiQ18973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 17Glutathione bindingBy similarity3
Regioni200 – 201Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiENOG410IJK9 Eukaryota
COG3917 LUCA
GeneTreeiENSGT00440000033697
HOGENOMiHOG000018051
InParanoidiQ18973
KOiK13299
OMAiPQFLFDF
OrthoDBiEOG091G0LCM
PhylomeDBiQ18973

Family and domain databases

InterProiView protein in InterPro
IPR001853 DSBA-like_thioredoxin_dom
IPR014440 HCCAis_GSTk
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF01323 DSBA, 1 hit
PIRSFiPIRSF006386 HCCAis_GSTk, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q18973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNRKVVKFF FDVISPYSYF GFEGITRHRS VWKTPIQMKP FFFAGVVRHT
60 70 80 90 100
ENPGLPLRIP IKEKYMHKDL LFSAQYWGIP FRLPKDYTNM MLNTSSIVPQ
110 120 130 140 150
RILVASQLRD NVLMEDVARG LWHRFYAYGK PIFTKSQVAE VLRDLHVKDV
160 170 180 190 200
DELVMMSDSA EVKNILRENT DEAIGNGCFG APWMHITDGH GKVLQTVFGS
210 220
DRLPQVADFL AEPFKGPMRE KKPNA
Length:225
Mass (Da):25,951
Last modified:November 1, 1996 - v1
Checksum:i23D0A3D6762B7232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080386 Genomic DNA Translation: CCD63360.1
PIRiT34201
RefSeqiNP_501148.1, NM_068747.4
UniGeneiCel.13215

Genome annotation databases

EnsemblMetazoaiD2024.7; D2024.7; WBGene00017054
GeneIDi177498
KEGGicel:CELE_D2024.7

Similar proteinsi

Entry informationi

Entry nameiGSTK2_CAEEL
AccessioniPrimary (citable) accession number: Q18973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health