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Protein

Eukaryotic translation initiation factor 3 subunit F

Gene

eif-3.F

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • translation Source: UniProtKB
  • translational initiation Source: GO_Central

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-CEL-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit FUniRule annotation
Short name:
eIF3fUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 5UniRule annotation
Gene namesi
Name:eif-3.FUniRule annotation
ORF Names:D2013.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi

Organism-specific databases

WormBaseiD2013.7 ; CE00932 ; WBGene00001229 ; eif-3.F

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Extended lifespan in adults.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003642921 – 294Eukaryotic translation initiation factor 3 subunit FAdd BLAST294

Proteomic databases

EPDiQ18967
PaxDbiQ18967
PeptideAtlasiQ18967
PRIDEiQ18967

Expressioni

Gene expression databases

BgeeiWBGene00001229

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi39802, 2 interactors
DIPiDIP-25689N
IntActiQ18967, 1 interactor
STRINGi6239.D2013.7.2

Structurei

3D structure databases

ProteinModelPortaliQ18967
SMRiQ18967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 155MPNPROSITE-ProRule annotationAdd BLAST149

Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2975 Eukaryota
COG1310 LUCA
GeneTreeiENSGT00530000063075
HOGENOMiHOG000241154
InParanoidiQ18967
KOiK03249
OMAiAVDMEYH
OrthoDBiEOG091G0EMR
PhylomeDBiQ18967

Family and domain databases

CDDicd08064 MPN_eIF3f, 1 hit
HAMAPiMF_03005 eIF3f, 1 hit
InterProiView protein in InterPro
IPR027531 eIF3f
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR024969 Rpn11/EIF3F_C
PANTHERiPTHR10540:SF6 PTHR10540:SF6, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF13012 MitMem_reg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequencei

Sequence statusi: Complete.

Q18967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNLTVNVH PGVYMNVVDT HMRRTKSSAK NTGQEKCMGT LMGYYEKGSI
60 70 80 90 100
QVTNCFAIPF NESNDDLEID DQFNQQMISA LKKTSPNEQP VGWFLTTSDI
110 120 130 140 150
TSSCLIYHDY YVRVITEASA RRESPPIVVL TIDTTFSGDM SKRMPVRAYL
160 170 180 190 200
RSKAGIPGAA GPHCAIFNPL RVELAAFPGE LVAMQLIEKA LDSRRREATL
210 220 230 240 250
ESGLEQLETS TAQMIEWLER MLHYVEDVNK NGEKPGDAQI GRQLMDIVTA
260 270 280 290
SSNNMQPEKL DTLVKNTLRD YVMVSYLAKL TQTQLQVHER LVSA
Length:294
Mass (Da):32,932
Last modified:November 1, 1996 - v1
Checksum:iA8F2B2ED09AB33AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47808 Genomic DNA Translation: CAA87773.1
PIRiT20338
RefSeqiNP_495988.1, NM_063587.6
UniGeneiCel.17162

Genome annotation databases

EnsemblMetazoaiD2013.7; D2013.7; WBGene00001229
GeneIDi174478
KEGGicel:CELE_D2013.7
UCSCiD2013.7 c. elegans

Similar proteinsi

Entry informationi

Entry nameiEIF3F_CAEEL
AccessioniPrimary (citable) accession number: Q18967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

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