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Protein

Eukaryotic translation initiation factor 3 subunit F

Gene

eif-3.F

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • formation of translation preinitiation complex Source: UniProtKB-HAMAP
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of translational initiation Source: UniProtKB-HAMAP
  • translation Source: UniProtKB
  • translational initiation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit FUniRule annotation
Short name:
eIF3fUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 5UniRule annotation
Gene namesi
Name:eif-3.FUniRule annotation
ORF Names:D2013.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiD2013.7; CE00932; WBGene00001229; eif-3.F.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Extended lifespan in adults.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003642921 – 294Eukaryotic translation initiation factor 3 subunit FAdd BLAST294

Proteomic databases

EPDiQ18967.
PaxDbiQ18967.
PeptideAtlasiQ18967.
PRIDEiQ18967.

Expressioni

Gene expression databases

BgeeiWBGene00001229.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi39802. 2 interactors.
DIPiDIP-25689N.
IntActiQ18967. 1 interactor.
MINTiMINT-1039602.
STRINGi6239.D2013.7.2.

Structurei

3D structure databases

ProteinModelPortaliQ18967.
SMRiQ18967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117MPNUniRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the eIF-3 subunit F family.UniRule annotation
Contains 1 MPN (JAB/Mov34) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG2975. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000241154.
InParanoidiQ18967.
KOiK03249.
OMAiRECNNPI.
OrthoDBiEOG091G0EMR.
PhylomeDBiQ18967.

Family and domain databases

CDDicd08064. MPN_eIF3f. 1 hit.
HAMAPiMF_03005. eIF3f. 1 hit.
InterProiIPR027531. eIF3f.
IPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNLTVNVH PGVYMNVVDT HMRRTKSSAK NTGQEKCMGT LMGYYEKGSI
60 70 80 90 100
QVTNCFAIPF NESNDDLEID DQFNQQMISA LKKTSPNEQP VGWFLTTSDI
110 120 130 140 150
TSSCLIYHDY YVRVITEASA RRESPPIVVL TIDTTFSGDM SKRMPVRAYL
160 170 180 190 200
RSKAGIPGAA GPHCAIFNPL RVELAAFPGE LVAMQLIEKA LDSRRREATL
210 220 230 240 250
ESGLEQLETS TAQMIEWLER MLHYVEDVNK NGEKPGDAQI GRQLMDIVTA
260 270 280 290
SSNNMQPEKL DTLVKNTLRD YVMVSYLAKL TQTQLQVHER LVSA
Length:294
Mass (Da):32,932
Last modified:November 1, 1996 - v1
Checksum:iA8F2B2ED09AB33AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47808 Genomic DNA. Translation: CAA87773.1.
PIRiT20338.
RefSeqiNP_495988.1. NM_063587.6.
UniGeneiCel.17162.

Genome annotation databases

EnsemblMetazoaiD2013.7; D2013.7; WBGene00001229.
GeneIDi174478.
KEGGicel:CELE_D2013.7.
UCSCiD2013.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47808 Genomic DNA. Translation: CAA87773.1.
PIRiT20338.
RefSeqiNP_495988.1. NM_063587.6.
UniGeneiCel.17162.

3D structure databases

ProteinModelPortaliQ18967.
SMRiQ18967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39802. 2 interactors.
DIPiDIP-25689N.
IntActiQ18967. 1 interactor.
MINTiMINT-1039602.
STRINGi6239.D2013.7.2.

Proteomic databases

EPDiQ18967.
PaxDbiQ18967.
PeptideAtlasiQ18967.
PRIDEiQ18967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiD2013.7; D2013.7; WBGene00001229.
GeneIDi174478.
KEGGicel:CELE_D2013.7.
UCSCiD2013.7. c. elegans.

Organism-specific databases

CTDi174478.
WormBaseiD2013.7; CE00932; WBGene00001229; eif-3.F.

Phylogenomic databases

eggNOGiKOG2975. Eukaryota.
COG1310. LUCA.
GeneTreeiENSGT00530000063075.
HOGENOMiHOG000241154.
InParanoidiQ18967.
KOiK03249.
OMAiRECNNPI.
OrthoDBiEOG091G0EMR.
PhylomeDBiQ18967.

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

PROiQ18967.

Gene expression databases

BgeeiWBGene00001229.

Family and domain databases

CDDicd08064. MPN_eIF3f. 1 hit.
HAMAPiMF_03005. eIF3f. 1 hit.
InterProiIPR027531. eIF3f.
IPR000555. JAMM/MPN+_dom.
IPR024969. Rpn11/EIF3F_C.
[Graphical view]
PfamiPF01398. JAB. 1 hit.
PF13012. MitMem_reg. 1 hit.
[Graphical view]
SMARTiSM00232. JAB_MPN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3F_CAEEL
AccessioniPrimary (citable) accession number: Q18967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.