ID   Q188Y1_CLOD6            Unreviewed;       567 AA.
AC   Q188Y1;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Methyl-accepting chemotaxis receptor,MCP family {ECO:0000313|EMBL:CAJ67371.1};
GN   OrderedLocusNames=CD630_05380 {ECO:0000313|EMBL:CAJ67371.1};
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ67371.1, ECO:0000313|Proteomes:UP000001978};
RN   [1] {ECO:0000313|EMBL:CAJ67371.1, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ67371.1,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AM180355; CAJ67371.1; -; Genomic_DNA.
DR   RefSeq; WP_003425090.1; NZ_JAUPES010000001.1.
DR   RefSeq; YP_001087014.1; NC_009089.1.
DR   AlphaFoldDB; Q188Y1; -.
DR   STRING; 272563.CD630_05380; -.
DR   EnsemblBacteria; CAJ67371; CAJ67371; CD630_05380.
DR   GeneID; 66353035; -.
DR   KEGG; cdf:CD630_05380; -.
DR   KEGG; pdc:CDIF630_00651; -.
DR   PATRIC; fig|272563.120.peg.547; -.
DR   eggNOG; COG0840; Bacteria.
DR   OrthoDB; 9814363at2; -.
DR   PhylomeDB; Q188Y1; -.
DR   BioCyc; PDIF272563:G12WB-650-MONOMER; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR024478; HlyB_4HB_MCP.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR43531:SF11; METHYL-ACCEPTING CHEMOTAXIS PROTEIN 3; 1.
DR   PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR   Pfam; PF12729; 4HB_MCP_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:CAJ67371.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW   Transducer {ECO:0000256|PROSITE-ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        185..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          209..262
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          312..541
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
SQ   SEQUENCE   567 AA;  61977 MW;  B2215F6B7C21ACCD CRC64;
     MKREVKLSKL AIVLLIIIVL AVLAGIFSSI SSYKAFEKVE KSINDMNNLR TQSQYIKDTT
     REISDVLRRY VFTGEKKNKD IYEKELYGKT RESALNKLEK IGLTKSESNK ILEAKEISDS
     LVPTEQSAIK AVESNDKSKA QSIIFGSDYI NSQEKMDSLI NEFQEDIVTR SNSKIVEVKK
     ELQSLILRTI FILSLLIILT IIEYTVIKLK IVIPINKVEK HFSRIASGDL RTSIDVEESK
     SEIGLLVSSV KKMQSMLLNY IDLIDSTLTS IAKGDLRVEI DQEFIGDFKS IKISLESIIN
     SFNGDFSEIN LSAEQVASAS EQVAAGAQAL SQGATEQASS VEELASTINE ISDGIKKCAD
     SASLACEVSD QSASQVGFGS RCMDDMMTSM GEISEKSSEI SKIIKTIDEI AFQTNILALN
     AAVEAARAGQ YGRGFAVVAD EVRSLAGKSA KAAQNTAILI EEAIKTVENG VRIAKETANA
     LDLVVNGVEK TTNYINGISS AVHSQEVAIT QILSGIEQIS IVVQMNSATA EESAAASEEM
     SAQAQILKEL VEKFHLKESE VRESSWV
//