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Protein
Submitted name:

PTS system, sucrose-specific IIABC component

Gene

CD630_04690

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Biological processi

Phosphotransferase systemSAAS annotation, Sugar transportSAAS annotation, Transport

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-593-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
PTS system, sucrose-specific IIABC componentImported (EC:2.7.1.69Imported)
Gene namesi
Ordered Locus Names:CD630_04690Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Transmembranei148 – 17225HelicalSequence analysisAdd
BLAST
Transmembranei184 – 20219HelicalSequence analysisAdd
BLAST
Transmembranei214 – 24229HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27825HelicalSequence analysisAdd
BLAST
Transmembranei298 – 32225HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35623HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41520HelicalSequence analysisAdd
BLAST
Transmembranei435 – 46127HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi272563.CD0469.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IPJX-ray1.20A/B2-93[»]
ProteinModelPortaliQ188R0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ188R0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8784PTS EIIB type-1InterPro annotationAdd
BLAST
Domaini119 – 475357PTS EIIC type-1InterPro annotationAdd
BLAST
Domaini499 – 602104PTS EIIA type-1InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains PTS EIIA type-1 domain.SAAS annotation
Contains PTS EIIB type-1 domain.SAAS annotation
Contains PTS EIIC type-1 domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C5Y. Bacteria.
COG1263. LUCA.
COG1264. LUCA.
COG2190. LUCA.
HOGENOMiHOG000102022.
KOiK02808.
K02809.
K02810.
OMAiGALINDS.
OrthoDBiEOG6ND0GQ.

Family and domain databases

Gene3Di3.30.1360.60. 1 hit.
InterProiIPR011055. Dup_hybrid_motif.
IPR018113. PTrfase_EIIB_Cys.
IPR001127. PTS_EIIA_1_perm.
IPR003352. PTS_EIIC.
IPR013013. PTS_EIIC_1.
IPR001996. PTS_IIB_1.
[Graphical view]
PfamiPF00358. PTS_EIIA_1. 1 hit.
PF00367. PTS_EIIB. 1 hit.
PF02378. PTS_EIIC. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
SSF55604. SSF55604. 1 hit.
TIGRFAMsiTIGR00830. PTBA. 1 hit.
PROSITEiPS51093. PTS_EIIA_TYPE_1. 1 hit.
PS51098. PTS_EIIB_TYPE_1. 1 hit.
PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit.
PS51103. PTS_EIIC_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q188R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYNKIANE LIKIIGEDNI ISITHCATRL RVMVKDREII NDKKVEKVDE
60 70 80 90 100
VKGVFFTSGQ YQIILGTGIV NKVYAEVEKM GLKTLSKKEQ DELVKNNETG
110 120 130 140 150
FKKVMRTLAD IFVPIIPVIA ATGLFLGLKG CLFNDNVLGL FGMSSANIPL
160 170 180 190 200
YIQTLVSVLT ETAFAFLPAI IVWSAFKVFG GTPVIGLVIG LMLVSPILPN
210 220 230 240 250
AYSVADPSNE IEAIMAFGFI PIVGCQGSVL TAIVTAFIGA NLEKWFRKHM
260 270 280 290 300
PNVLDLIFTP FFVMLITMLV ILLGVGPIMH TIELKMVDII SLLIDLPLGI
310 320 330 340 350
GGFIIGFTYP LAVITGLHHT YVMIETSLLA NTGFNALITL CAMYGFANIG
360 370 380 390 400
TCLAFMKKSK NNQVKQTAVG AMLSQLFGIS EPVLFGIQLR YNLKPLIIMC
410 420 430 440 450
ASSGLGAAIL SILHIQSNSY GLAVLPSYLM YIYDGYNLIT YLLVSIFVVA
460 470 480 490 500
FCFIVTCLFG VPKEAINEDE DEELVFNENN ENFVSPAKGK IVALENVPDE
510 520 530 540 550
TFSKKMLGDG FAIDIIDGKI VSPISGKLET VFSSGHAFGI KGTNGEVLIH
560 570 580 590 600
VGIDTVALNG DGFDVAVKQG DMVKQGDVLV NVDLKRIHEL GKSTLTMVLF
610 620
PDGKKVNILD INKDVKIGQR ICVE
Length:624
Mass (Da):67,961
Last modified:July 25, 2006 - v1
Checksum:i5B01699735E9611B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67297.1.
RefSeqiWP_011860826.1. NZ_CP010905.1.
YP_001086942.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ67297; CAJ67297; CD630_04690.
GeneIDi4914240.
KEGGicdf:CD630_04690.
pdc:CDIF630_00597.
PATRICi19439199. VBICloDif38397_0493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ67297.1.
RefSeqiWP_011860826.1. NZ_CP010905.1.
YP_001086942.1. NC_009089.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IPJX-ray1.20A/B2-93[»]
ProteinModelPortaliQ188R0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD0469.

Protocols and materials databases

DNASUi4914240.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ67297; CAJ67297; CD630_04690.
GeneIDi4914240.
KEGGicdf:CD630_04690.
pdc:CDIF630_00597.
PATRICi19439199. VBICloDif38397_0493.

Phylogenomic databases

eggNOGiENOG4105C5Y. Bacteria.
COG1263. LUCA.
COG1264. LUCA.
COG2190. LUCA.
HOGENOMiHOG000102022.
KOiK02808.
K02809.
K02810.
OMAiGALINDS.
OrthoDBiEOG6ND0GQ.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-593-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ188R0.

Family and domain databases

Gene3Di3.30.1360.60. 1 hit.
InterProiIPR011055. Dup_hybrid_motif.
IPR018113. PTrfase_EIIB_Cys.
IPR001127. PTS_EIIA_1_perm.
IPR003352. PTS_EIIC.
IPR013013. PTS_EIIC_1.
IPR001996. PTS_IIB_1.
[Graphical view]
PfamiPF00358. PTS_EIIA_1. 1 hit.
PF00367. PTS_EIIB. 1 hit.
PF02378. PTS_EIIC. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
SSF55604. SSF55604. 1 hit.
TIGRFAMsiTIGR00830. PTBA. 1 hit.
PROSITEiPS51093. PTS_EIIA_TYPE_1. 1 hit.
PS51098. PTS_EIIB_TYPE_1. 1 hit.
PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit.
PS51103. PTS_EIIC_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630Imported.
  2. "The crystal structure of one domain of the PTS system, IIabc component from Clostridium difficile."
    Zhang R., Bigelow L., Cobb G., Joachimiak A.
    Submitted (AUG-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 2-93.

Entry informationi

Entry nameiQ188R0_PEPD6
AccessioniPrimary (citable) accession number: Q188R0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.