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Q188C8 (SYQ_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine--tRNA ligase
EC=6.1.1.18
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS
Gene names
Name:glnS
Ordered Locus Names:CD630_20590
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). HAMAP MF_00126

Subunit structure

Monomer By similarity. HAMAP MF_00126

Subcellular location

Cytoplasm By similarity HAMAP MF_00126.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglutaminyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Glutamine--tRNA ligase HAMAP MF_00126
PRO_1000095482

Regions

Motif33 – 4311"HIGH" region HAMAP MF_00126
Motif266 – 2705"KMSKS" region HAMAP MF_00126

Sites

Binding site2691ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q188C8 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: E9AB923D5FAE0B4D

FASTA55464,281
        10         20         30         40         50         60 
MSNETNSSNF IKNIIINDLE TGKHDSIITR FPPEPNGYLH IGHAKSICLN FGLAKEFNGK 

        70         80         90        100        110        120 
ANLRFDDTNP LKEDVEYVES IKEDVKWLGF DWNELNFASN YFDEMYKRAL ILIKKGKAYV 

       130        140        150        160        170        180 
CDLTQEEMRE YRGTLTEPGK ESPHRNRTIE ENLDLFERMK NGEFKDGEKT LRAKIDMSSP 

       190        200        210        220        230        240 
NINLRDPIIY RISHSTHHNT GDKWCIYPMY AFAHPIEDAI EGITHSICTL EFEDQRPLYD 

       250        260        270        280        290        300 
WFVKECEMEN IPRQIEFARL NINNTVMSKR KLKQLVDEGI VDGWDDPRVP TISGIRRKGY 

       310        320        330        340        350        360 
TAEALRNFCS EIGVSKVNST VDSQMLDYFL RENLQPKAPL TMGVLRPLKL IITNYPEDKI 

       370        380        390        400        410        420 
EMLEIENNAK DESQGKRLVP FSRELYIEQD DFMEEPVKKY FRFFPGNEVR LKGAYFVKCT 

       430        440        450        460        470        480 
DVIKDENGNV VEIHGTYDPE TKSGSGFTGR KVKSTIHWVD AKSAIPCEFR LFEPLILDDI 

       490        500        510        520        530        540 
PENEGKHFLE QINPNSLEIL QGFVEPTQIK DAKPFDKFQF VRNGFFSIDN KYTTDEKFVF 

       550 
NRIVPLKSSF KPGK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM180355 Genomic DNA. Translation: CAJ68944.1.
RefSeqYP_001088573.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ188C8.
SMRQ188C8. Positions 8-549.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ188C8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4915499.
GenomeReviewsGene locus CD2059 in contig AM180355_GR.
KEGGcdf:CD2059.
NMPDRfig|1496.1.peg.2720.
PATRIC19442559. VBICloDif38397_2166.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHBG334108.
OMARMPTIAG.
ProtClustDBPRK05347.

Family and domain databases

HAMAPMF_00126. Gln_tRNA_synth.
[Tree]
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth_Ib.
IPR022861. Gln_tRNA_synth_bac.
IPR000924. Glu/Gln-tRNA-synth_Ib.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:1.10.1160.10. Glu/Gln-tRNA-synth_Ic_a-bdl. 1 hit.
G3DSA:2.40.240.10. Rbsml_L25/Gln-tRNA_synth_b-brl. 2 hits.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KOK01886.
PANTHERPTHR10119. Glu_tRNA-synt_1c. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. Ribosomal_L25rel. 1 hit.
TIGRFAMsTIGR00440. GlnS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYQ_CLOD6
AccessionPrimary (citable) accession number: Q188C8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 25, 2006
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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