Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

C55C3.4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ18865.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:C55C3.4Imported, CELE_C55C3.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC55C3.4; CE06991; WBGene00016954.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ18865.
PaxDbiQ18865.
PRIDEiQ18865.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C55C3.4.

Structurei

3D structure databases

ProteinModelPortaliQ18865.
SMRiQ18865. Positions 4-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 10999SH2InterPro annotationAdd
BLAST
Domaini121 – 380260Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ18865.
OMAiNIYDITH.
OrthoDBiEOG708VXW.
PhylomeDBiQ18865.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKDLLHQK YYHGLLPRED IQEMLNKPGQ FLLRTSEPVK GEKRQFVLSV
60 70 80 90 100
VGEKNTSANH FVVREADHKV YVDKIGFPTI IELVNHYVST KESFSTKDGT
110 120 130 140 150
VKVVLKHAVE RQKWELYHED VELTKKLGEG AFGEVWKGKL LKILDANHQP
160 170 180 190 200
VLVAVKTAKL ESMTKEQIKE IMREARLMRN LDHINVVKFF GVAAGTEPLY
210 220 230 240 250
VIMELADGGA LDSALGKLHF PMIKKYELIY QAANGLAYIH EKNLMHRDVA
260 270 280 290 300
ARNCLYGGGQ VKIADFGLSR EGADYTMDLK KKVPIRWLPP ETIRSGLYTP
310 320 330 340 350
KTDVFAFGVM AWEITEDGKE PYPGFKVIEV AMKVLQGYRM PFSPEVNKEF
360 370 380 390 400
AEFILTKCWP EKYEDRLPMK DICKWMKSSV KAQGGDTGPG GMMSKFGKKI
410 420 430
KRSNSRESKS KSSTMTAAHG HDQGAMTAIE K
Length:431
Mass (Da):48,790
Last modified:November 1, 1996 - v1
Checksum:i5FFEF7CCE260CE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD68147.1.
PIRiT29186.
RefSeqiNP_500846.1. NM_068445.4.
UniGeneiCel.23405.

Genome annotation databases

EnsemblMetazoaiC55C3.4; C55C3.4; WBGene00016954.
GeneIDi177346.
KEGGicel:CELE_C55C3.4.
UCSCiC55C3.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD68147.1.
PIRiT29186.
RefSeqiNP_500846.1. NM_068445.4.
UniGeneiCel.23405.

3D structure databases

ProteinModelPortaliQ18865.
SMRiQ18865. Positions 4-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C55C3.4.

Proteomic databases

EPDiQ18865.
PaxDbiQ18865.
PRIDEiQ18865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC55C3.4; C55C3.4; WBGene00016954.
GeneIDi177346.
KEGGicel:CELE_C55C3.4.
UCSCiC55C3.4. c. elegans.

Organism-specific databases

CTDi177346.
WormBaseiC55C3.4; CE06991; WBGene00016954.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiQ18865.
OMAiNIYDITH.
OrthoDBiEOG708VXW.
PhylomeDBiQ18865.

Enzyme and pathway databases

SignaLinkiQ18865.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ18865_CAEEL
AccessioniPrimary (citable) accession number: Q18865
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.