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Protein

Tyrosine-protein kinase

Gene

C55C3.4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ18865.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:C55C3.4Imported, CELE_C55C3.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC55C3.4; CE06991; WBGene00016954.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

EPDiQ18865.
PaxDbiQ18865.
PeptideAtlasiQ18865.

Expressioni

Gene expression databases

BgeeiWBGene00016954.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.C55C3.4.

Structurei

3D structure databases

ProteinModelPortaliQ18865.
SMRiQ18865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 109SH2InterPro annotationAdd BLAST99
Domaini121 – 380Protein kinaseInterPro annotationAdd BLAST260

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00900000141267.
HOGENOMiHOG000233858.
InParanoidiQ18865.
OMAiMYFRADK.
OrthoDBiEOG091G0C33.
PhylomeDBiQ18865.

Family and domain databases

CDDicd10361. SH2_Fps_family. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR035849. Fes/Fps/Fer_SH2.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKDLLHQK YYHGLLPRED IQEMLNKPGQ FLLRTSEPVK GEKRQFVLSV
60 70 80 90 100
VGEKNTSANH FVVREADHKV YVDKIGFPTI IELVNHYVST KESFSTKDGT
110 120 130 140 150
VKVVLKHAVE RQKWELYHED VELTKKLGEG AFGEVWKGKL LKILDANHQP
160 170 180 190 200
VLVAVKTAKL ESMTKEQIKE IMREARLMRN LDHINVVKFF GVAAGTEPLY
210 220 230 240 250
VIMELADGGA LDSALGKLHF PMIKKYELIY QAANGLAYIH EKNLMHRDVA
260 270 280 290 300
ARNCLYGGGQ VKIADFGLSR EGADYTMDLK KKVPIRWLPP ETIRSGLYTP
310 320 330 340 350
KTDVFAFGVM AWEITEDGKE PYPGFKVIEV AMKVLQGYRM PFSPEVNKEF
360 370 380 390 400
AEFILTKCWP EKYEDRLPMK DICKWMKSSV KAQGGDTGPG GMMSKFGKKI
410 420 430
KRSNSRESKS KSSTMTAAHG HDQGAMTAIE K
Length:431
Mass (Da):48,790
Last modified:November 1, 1996 - v1
Checksum:i5FFEF7CCE260CE37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD68147.1.
PIRiT29186.
RefSeqiNP_500846.1. NM_068445.4.
UniGeneiCel.23405.

Genome annotation databases

EnsemblMetazoaiC55C3.4; C55C3.4; WBGene00016954.
GeneIDi177346.
KEGGicel:CELE_C55C3.4.
UCSCiC55C3.4. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ18865_CAEEL
AccessioniPrimary (citable) accession number: Q18865
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported