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Protein

Beta-catenin/armadillo-related protein 1

Gene

bar-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2.8 Publications

GO - Molecular functioni

  • alpha-catenin binding Source: GO_Central
  • cadherin binding Source: GO_Central
  • protein phosphatase binding Source: GO_Central
  • signal transducer activity Source: InterPro
  • transcription coactivator activity Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

  • adherens junction assembly Source: InterPro
  • cell adhesion Source: UniProtKB
  • cell fate specification Source: UniProtKB
  • cellular response to oxidative stress Source: ParkinsonsUK-UCL
  • dauer larval development Source: ParkinsonsUK-UCL
  • determination of adult lifespan Source: ParkinsonsUK-UCL
  • establishment of mitotic spindle orientation Source: UniProtKB
  • hermaphrodite genitalia development Source: WormBase
  • left/right axis specification Source: UniProtKB
  • mating behavior Source: WormBase
  • morphogenesis of an epithelium Source: WormBase
  • oviposition Source: WormBase
  • positive regulation of distal tip cell migration Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • positive regulation of vulval development Source: WormBase
  • Ras protein signal transduction Source: WormBase
  • regulation of backward locomotion Source: WormBase
  • regulation of cell fate specification Source: WormBase
  • regulation of cell migration Source: WormBase
  • regulation of vulval development Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-CEL-5218920. VEGFR2 mediated vascular permeability.
R-CEL-6798695. Neutrophil degranulation.
SignaLinkiQ18825.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin/armadillo-related protein 1
Alternative name(s):
Protruding vulva protein 1
Suppressor of polyray 1
Gene namesi
Name:bar-1Imported
Synonyms:pvl-1, spy-1
ORF Names:C54D1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC54D1.6; CE08973; WBGene00000238; bar-1.

Subcellular locationi

  • Cytoplasm 2 Publications
  • Nucleus 2 Publications
  • Membrane 2 Publications
  • Cell junction 2 Publications

  • Note: Mostly cytoplasmic.2 Publications

GO - Cellular componenti

  • catenin complex Source: GO_Central
  • cell-cell adherens junction Source: WormBase
  • cell junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: WormBase
  • membrane Source: WormBase
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi239S → L in ep451; interferes with neuroblast Q migration. 1 Publication1
Mutagenesisi278V → G in ep484; interferes with neuroblast Q migration; in association with Asn-281. 1 Publication1
Mutagenesisi281D → N in ep484; interferes with neuroblast Q migration; in association with Gly-278. 1 Publication1
Mutagenesisi369S → K in ep466; interferes with neuroblast Q migration. 1 Publication1
Mutagenesisi449E → K in ep487/ep478; variable interference with neuroblast Q migration. 1 Publication1
Mutagenesisi460R → W in ep461; interferes with neuroblast Q migration. 1 Publication1
Mutagenesisi482L → I in mu349; suppresses ectopic expression of mab-5 and interferes with neuroblast Q migration. 2 Publications1
Mutagenesisi498T → I in ep485; interferes with neuroblast Q migration. 1 Publication1
Mutagenesisi524G → D in ep460/mu63; suppresses ectopic expression of mab-5. 2 Publications1
Mutagenesisi524G → S in ep486; interferes with neuroblast Q migration. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003728051 – 811Beta-catenin/armadillo-related protein 1Add BLAST811

Proteomic databases

PaxDbiQ18825.
PRIDEiQ18825.

Expressioni

Tissue specificityi

Expressed in body wall muscle cells, hypodermal seam cells, gonad sheath cells and vulval precursor cells.2 Publications

Developmental stagei

Detected throughout development from L1 to L4 and during adulthood. Detected from the P3.p cell stage through to P8.p.2 Publications

Gene expression databases

BgeeiWBGene00000238.

Interactioni

Subunit structurei

Interacts with apr-1, axl-1, daf-16, lin-23, and pop-1 (via acidic region in N-terminus 1-44). Interacts (via ARM repeats) with pry-1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
pop-1Q106666EBI-2528850,EBI-317870
pry-1O620903EBI-2528850,EBI-2917690

GO - Molecular functioni

Protein-protein interaction databases

BioGridi45907. 183 interactors.
IntActiQ18825. 20 interactors.
MINTiMINT-214589.
STRINGi6239.C54D1.6.

Structurei

3D structure databases

ProteinModelPortaliQ18825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati108 – 147ARM 1Sequence analysisAdd BLAST40
Repeati331 – 369ARM 2Sequence analysisAdd BLAST39
Repeati370 – 408ARM 3Sequence analysisAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 85Involved in transcriptional activation1 PublicationAdd BLAST85
Regioni541 – 811Involved in transcriptional activation1 PublicationAdd BLAST271

Sequence similaritiesi

Belongs to the beta-catenin family.Sequence analysis
Contains 3 ARM repeats.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000095175.
InParanoidiQ18825.
KOiK02105.
OMAiNIAKMEC.
OrthoDBiEOG091G02PY.
PhylomeDBiQ18825.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR030462. BAR-1.
IPR013284. Beta-catenin.
[Graphical view]
PANTHERiPTHR23315:SF134. PTHR23315:SF134. 2 hits.
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDPNLVIN HDDTNLSEAS FTMEQHTSSY SDIHMGSTPC TGHRKVDMWR
60 70 80 90 100
NHNFDSGFQT MNHSEAPSII SSLHPSSHLS GMSSMADYEP IPTLSDQQKQ
110 120 130 140 150
KFDGITQNQA DGQYNTVRAI PELTMLMKDQ DNEVVHKAVI LMQNIAKMEC
160 170 180 190 200
DPMRRQNEAR IVDPRVIFTL RDLLRDKVEF PNIIRCTLGT FFHICNRQEG
210 220 230 240 250
IDLVTRAIAE QPDIIPNLIR HIGTYPSSIY KYAILTMHSI LSDKQRGGQS
260 270 280 290 300
VIIARQQDAI THVTPWLEAE KSEKLLPVIV DLIRVLCEKN TEQKIKFVKM
310 320 330 340 350
GGPQKLLMLL QHRVYENLLW RTTQLLKTFS NFDAPNLVAF GGRQILANLL
360 370 380 390 400
SHGSPRLVQS TLETLRNISD VPSKIKEDLL LKSLLELVNS RNTTIRLYSA
410 420 430 440 450
QIMSNLVANN RHNKEFMCGN NGVVILVRAL TIATKEMGDL RDKEAQQMED
460 470 480 490 500
YIESLICTLR HLCVGHPMSD KVQAFVFRDP ALFLHKLLTM RPVLLKHTLS
510 520 530 540 550
LLLKVVSQHA LLAPFRSCRI GDKGFVEQLI HILRVACTQL NVQESIEGVR
560 570 580 590 600
VKDIIHLCIQ ILRWITRDQD ILNEVVFFLQ TPENSRMGDG HTLPIFVLQK
610 620 630 640 650
ANVEENTKSS ALALIYNLMH HEQMANVLDR DDVLVKMLQN VQMQSQTHPE
660 670 680 690 700
LASLANNILK MMYEKREKTR NTLPRYNSYL ESQFGHMSMT TPRSEALNSS
710 720 730 740 750
GEVCEGAGEQ WSTPLTDDTM MDSYCNSSGR DSSKPYNSPM YHSPPAMYPE
760 770 780 790 800
YSIGPPETYL DPHATASCYP RPTPPQYNSY DRSPPVYNDL PSNPGPSSHS
810
SDYYPSRNSR F
Length:811
Mass (Da):92,228
Last modified:June 1, 1998 - v2
Checksum:i97D6FFDE71BDFDFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063646 mRNA. Translation: AAC17424.1.
FO080795 Genomic DNA. Translation: CCD66852.1.
PIRiT43175.
RefSeqiNP_509206.1. NM_076805.5.
UniGeneiCel.5480.

Genome annotation databases

EnsemblMetazoaiC54D1.6; C54D1.6; WBGene00000238.
GeneIDi180982.
KEGGicel:CELE_C54D1.6.
UCSCiC54D1.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063646 mRNA. Translation: AAC17424.1.
FO080795 Genomic DNA. Translation: CCD66852.1.
PIRiT43175.
RefSeqiNP_509206.1. NM_076805.5.
UniGeneiCel.5480.

3D structure databases

ProteinModelPortaliQ18825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45907. 183 interactors.
IntActiQ18825. 20 interactors.
MINTiMINT-214589.
STRINGi6239.C54D1.6.

Proteomic databases

PaxDbiQ18825.
PRIDEiQ18825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC54D1.6; C54D1.6; WBGene00000238.
GeneIDi180982.
KEGGicel:CELE_C54D1.6.
UCSCiC54D1.6.1. c. elegans.

Organism-specific databases

CTDi180982.
WormBaseiC54D1.6; CE08973; WBGene00000238; bar-1.

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000095175.
InParanoidiQ18825.
KOiK02105.
OMAiNIAKMEC.
OrthoDBiEOG091G02PY.
PhylomeDBiQ18825.

Enzyme and pathway databases

ReactomeiR-CEL-5218920. VEGFR2 mediated vascular permeability.
R-CEL-6798695. Neutrophil degranulation.
SignaLinkiQ18825.

Miscellaneous databases

PROiQ18825.

Gene expression databases

BgeeiWBGene00000238.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR030462. BAR-1.
IPR013284. Beta-catenin.
[Graphical view]
PANTHERiPTHR23315:SF134. PTHR23315:SF134. 2 hits.
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBAR1_CAEEL
AccessioniPrimary (citable) accession number: Q18825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Worms lacking bar-1 exhibit abnormalities in vulval development due to incorrect cell fate specification, resulting in the following phenotypes, multivulva (Muv), protruding vulva (Pvl) and egg laying defective (Egl). Mutants also show defects in Q neuroblast migration, uncoordinated movement (Unc) and reduced superoxidase dismutase levels. Null mutants can be rescued by wrm-1 and hmp-2 when expressed from the bar-1 promoter. Double mutants also lacking dpy-22 show reduced body length, male tail morphology abnormalities (Mab) and dauer induction.5 Publications

Caution

Alleles mu63 and mu349 were originally reported (PubMed:9834184) as the mutations L130F and Q147STOP respectively. This is in conflict with WormBase and more recent literature (PubMed:15282167) which is represented in this entry.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.