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Q18825

- BAR1_CAEEL

UniProt

Q18825 - BAR1_CAEEL

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Protein

Beta-catenin/armadillo-related protein 1

Gene
bar-1, pvl-1, spy-1, C54D1.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2.8 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. transcription coactivator activity Source: WormBase
  3. transcription factor binding Source: WormBase

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. cell fate specification Source: UniProtKB
  3. hermaphrodite genitalia development Source: WormBase
  4. mating behavior Source: WormBase
  5. morphogenesis of an epithelium Source: WormBase
  6. oviposition Source: WormBase
  7. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  8. positive regulation of vulval development Source: WormBase
  9. Ras protein signal transduction Source: WormBase
  10. regulation of backward locomotion Source: WormBase
  11. regulation of cell fate specification Source: WormBase
  12. regulation of cell migration Source: WormBase
  13. regulation of vulval development Source: WormBase
  14. transcription, DNA-templated Source: UniProtKB-KW
  15. Wnt signaling pathway Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiQ18825.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin/armadillo-related protein 1
Alternative name(s):
Protruding vulva protein 1
Suppressor of polyray 1
Gene namesi
Name:bar-1
Synonyms:pvl-1, spy-1
ORF Names:C54D1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC54D1.6; CE08973; WBGene00000238; bar-1.

Subcellular locationi

Cytoplasm. Nucleus. Membrane. Cell junction
Note: Mostly cytoplasmic.2 Publications

GO - Cellular componenti

  1. cell-cell adherens junction Source: WormBase
  2. cell junction Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytosol Source: WormBase
  5. membrane Source: WormBase
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi239 – 2391S → L in ep451; interferes with neuroblast Q migration. 1 Publication
Mutagenesisi278 – 2781V → G in ep484; interferes with neuroblast Q migration; in association with Asn-281. 1 Publication
Mutagenesisi281 – 2811D → N in ep484; interferes with neuroblast Q migration; in association with Gly-278. 1 Publication
Mutagenesisi369 – 3691S → K in ep466; interferes with neuroblast Q migration. 1 Publication
Mutagenesisi449 – 4491E → K in ep487/ep478; variable interference with neuroblast Q migration. 1 Publication
Mutagenesisi460 – 4601R → W in ep461; interferes with neuroblast Q migration. 1 Publication
Mutagenesisi482 – 4821L → I in mu349; suppresses ectopic expression of mab-5 and interferes with neuroblast Q migration. 3 Publications
Mutagenesisi498 – 4981T → I in ep485; interferes with neuroblast Q migration. 1 Publication
Mutagenesisi524 – 5241G → D in ep460/mu63; suppresses ectopic expression of mab-5. 3 Publications
Mutagenesisi524 – 5241G → S in ep486; interferes with neuroblast Q migration. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Beta-catenin/armadillo-related protein 1PRO_0000372805Add
BLAST

Proteomic databases

PaxDbiQ18825.
PRIDEiQ18825.

Expressioni

Tissue specificityi

Expressed in body wall muscle cells, hypodermal seam cells, gonad sheath cells and vulval precursor cells.3 Publications

Developmental stagei

Detected throughout development from L1 to L4 and during adulthood. Detected from the P3.p cell stage through to P8.p.3 Publications

Interactioni

Subunit structurei

Interacts with apr-1, axl-1, daf-16, lin-23, and pop-1 (via acidic region in N-terminus 1-44). Interacts (via ARM repeats) with pry-1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
pop-1Q106665EBI-2528850,EBI-317870
pry-1O620903EBI-2528850,EBI-2917690

Protein-protein interaction databases

BioGridi45907. 183 interactions.
IntActiQ18825. 4 interactions.
MINTiMINT-214589.
STRINGi6239.C54D1.6.2.

Structurei

3D structure databases

ProteinModelPortaliQ18825.
SMRiQ18825. Positions 109-678.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati108 – 14740ARM 1Add
BLAST
Repeati331 – 36939ARM 2Add
BLAST
Repeati370 – 40839ARM 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8585Involved in transcriptional activation1 PublicationAdd
BLAST
Regioni541 – 811271Involved in transcriptional activation1 PublicationAdd
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 3 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG249506.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000095175.
InParanoidiQ18825.
KOiK02105.
OMAiNIAKMEC.
OrthoDBiEOG7X0VMV.
PhylomeDBiQ18825.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18825-1 [UniParc]FASTAAdd to Basket

« Hide

MDLDPNLVIN HDDTNLSEAS FTMEQHTSSY SDIHMGSTPC TGHRKVDMWR    50
NHNFDSGFQT MNHSEAPSII SSLHPSSHLS GMSSMADYEP IPTLSDQQKQ 100
KFDGITQNQA DGQYNTVRAI PELTMLMKDQ DNEVVHKAVI LMQNIAKMEC 150
DPMRRQNEAR IVDPRVIFTL RDLLRDKVEF PNIIRCTLGT FFHICNRQEG 200
IDLVTRAIAE QPDIIPNLIR HIGTYPSSIY KYAILTMHSI LSDKQRGGQS 250
VIIARQQDAI THVTPWLEAE KSEKLLPVIV DLIRVLCEKN TEQKIKFVKM 300
GGPQKLLMLL QHRVYENLLW RTTQLLKTFS NFDAPNLVAF GGRQILANLL 350
SHGSPRLVQS TLETLRNISD VPSKIKEDLL LKSLLELVNS RNTTIRLYSA 400
QIMSNLVANN RHNKEFMCGN NGVVILVRAL TIATKEMGDL RDKEAQQMED 450
YIESLICTLR HLCVGHPMSD KVQAFVFRDP ALFLHKLLTM RPVLLKHTLS 500
LLLKVVSQHA LLAPFRSCRI GDKGFVEQLI HILRVACTQL NVQESIEGVR 550
VKDIIHLCIQ ILRWITRDQD ILNEVVFFLQ TPENSRMGDG HTLPIFVLQK 600
ANVEENTKSS ALALIYNLMH HEQMANVLDR DDVLVKMLQN VQMQSQTHPE 650
LASLANNILK MMYEKREKTR NTLPRYNSYL ESQFGHMSMT TPRSEALNSS 700
GEVCEGAGEQ WSTPLTDDTM MDSYCNSSGR DSSKPYNSPM YHSPPAMYPE 750
YSIGPPETYL DPHATASCYP RPTPPQYNSY DRSPPVYNDL PSNPGPSSHS 800
SDYYPSRNSR F 811
Length:811
Mass (Da):92,228
Last modified:June 1, 1998 - v2
Checksum:i97D6FFDE71BDFDFF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063646 mRNA. Translation: AAC17424.1.
FO080795 Genomic DNA. Translation: CCD66852.1.
PIRiT43175.
RefSeqiNP_509206.1. NM_076805.5.
UniGeneiCel.5480.

Genome annotation databases

EnsemblMetazoaiC54D1.6; C54D1.6; WBGene00000238.
GeneIDi180982.
KEGGicel:CELE_C54D1.6.
UCSCiC54D1.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF063646 mRNA. Translation: AAC17424.1 .
FO080795 Genomic DNA. Translation: CCD66852.1 .
PIRi T43175.
RefSeqi NP_509206.1. NM_076805.5.
UniGenei Cel.5480.

3D structure databases

ProteinModelPortali Q18825.
SMRi Q18825. Positions 109-678.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 45907. 183 interactions.
IntActi Q18825. 4 interactions.
MINTi MINT-214589.
STRINGi 6239.C54D1.6.2.

Proteomic databases

PaxDbi Q18825.
PRIDEi Q18825.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C54D1.6 ; C54D1.6 ; WBGene00000238 .
GeneIDi 180982.
KEGGi cel:CELE_C54D1.6.
UCSCi C54D1.6.1. c. elegans.

Organism-specific databases

CTDi 180982.
WormBasei C54D1.6 ; CE08973 ; WBGene00000238 ; bar-1.

Phylogenomic databases

eggNOGi NOG249506.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000095175.
InParanoidi Q18825.
KOi K02105.
OMAi NIAKMEC.
OrthoDBi EOG7X0VMV.
PhylomeDBi Q18825.

Enzyme and pathway databases

SignaLinki Q18825.

Miscellaneous databases

NextBioi 911834.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 3 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development."
    Eisenmann D.M., Maloof J.N., Simske J.S., Kenyon C., Kim S.K.
    Development 125:3667-3680(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans."
    Maloof J.N., Whangbo J., Harris J.M., Jongeward G.D., Kenyon C.
    Development 126:37-49(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LEU-482 AND GLY-524.
  4. "Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development."
    Eisenmann D.M., Kim S.K.
    Genetics 156:1097-1116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "Distinct beta-catenins mediate adhesion and signalling functions in C. elegans."
    Korswagen H.C., Herman M.A., Clevers H.C.
    Nature 406:527-532(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH POP-1.
  6. "The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo."
    Natarajan L., Witwer N.E., Eisenmann D.M.
    Genetics 159:159-172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH APR-1 AND POP-1.
  7. "The axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans."
    Korswagen H.C., Coudreuse D.Y.M., Betist M.C., van de Water S., Zivkovic D., Clevers H.C.
    Genes Dev. 16:1291-1302(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRY-1.
  8. "A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans."
    Moghal N., Sternberg P.W.
    Development 130:57-69(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Identification of evolutionarily conserved promoter elements and amino acids required for function of the C. elegans beta-catenin homolog BAR-1."
    Natarajan L., Jackson B.M., Szyleyko E., Eisenmann D.M.
    Dev. Biol. 272:536-557(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, MUTAGENESIS OF SER-239; VAL-278; ASP-281; SER-369; GLU-449; ARG-460; LEU-482; THR-498 AND GLY-524.
  10. "LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans."
    Dreier L., Burbea M., Kaplan J.M.
    Neuron 46:51-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH LIN-23.
  11. "Functional interaction between beta-catenin and FOXO in oxidative stress signaling."
    Essers M.A.G., de Vries-Smits L.M.M., Barker N., Polderman P.E., Burgering B.M.T., Korswagen H.C.
    Science 308:1181-1184(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DAF-16.
  12. "Two functionally distinct axin-like proteins regulate canonical Wnt signaling in C. elegans."
    Oosterveen T., Coudreuse D.Y.M., Yang P.-T., Fraser E., Bergsma J., Dale T.C., Korswagen H.C.
    Dev. Biol. 308:438-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXL-1.

Entry informationi

Entry nameiBAR1_CAEEL
AccessioniPrimary (citable) accession number: Q18825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 1998
Last modified: June 11, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Worms lacking bar-1 exhibit abnormalities in vulval development due to incorrect cell fate specification, resulting in the following phenotypes, multivulva (Muv), protruding vulva (Pvl) and egg laying defective (Egl). Mutants also show defects in Q neuroblast migration, uncoordinated movement (Unc) and reduced superoxidase dismutase levels. Null mutants can be rescued by wrm-1 and hmp-2 when expressed from the bar-1 promoter. Double mutants also lacking dpy-22 show reduced body length, male tail morphology abnormalities (Mab) and dauer induction.5 Publications

Caution

Alleles mu63 and mu349 were originally reported (1 Publication) as the mutations L130F and Q147STOP respectively. This is in conflict with WormBase and more recent literature (1 Publication) which is represented in this entry.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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