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Protein

Laminin-like protein lam-2

Gene

lam-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3.1 Publication

GO - Biological processi

  • basement membrane assembly Source: InterPro
  • positive regulation of locomotion Source: WormBase
  • system development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Laminin-like protein lam-2
Gene namesi
Name:lam-2
ORF Names:C54D1.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC54D1.5; CE45033; WBGene00016913; lam-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001709920 – 1633Laminin-like protein lam-2Add BLAST1614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...)1 Publication1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi287 ↔ 296PROSITE-ProRule annotation
Disulfide bondi289 ↔ 310PROSITE-ProRule annotation
Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi324 ↔ 344PROSITE-ProRule annotation
Disulfide bondi347 ↔ 356PROSITE-ProRule annotation
Glycosylationi348N-linked (GlcNAc...)1 Publication1
Disulfide bondi349 ↔ 372PROSITE-ProRule annotation
Disulfide bondi375 ↔ 384PROSITE-ProRule annotation
Disulfide bondi387 ↔ 400PROSITE-ProRule annotation
Disulfide bondi403 ↔ 415PROSITE-ProRule annotation
Disulfide bondi405 ↔ 421PROSITE-ProRule annotation
Disulfide bondi423 ↔ 432PROSITE-ProRule annotation
Disulfide bondi435 ↔ 447PROSITE-ProRule annotation
Disulfide bondi450 ↔ 464PROSITE-ProRule annotation
Disulfide bondi452 ↔ 471PROSITE-ProRule annotation
Disulfide bondi473 ↔ 482PROSITE-ProRule annotation
Disulfide bondi485 ↔ 500PROSITE-ProRule annotation
Glycosylationi522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi658N-linked (GlcNAc...)2 Publications1
Disulfide bondi736 ↔ 745PROSITE-ProRule annotation
Disulfide bondi738 ↔ 752PROSITE-ProRule annotation
Glycosylationi740N-linked (GlcNAc...)1 Publication1
Disulfide bondi754 ↔ 763PROSITE-ProRule annotation
Disulfide bondi766 ↔ 782PROSITE-ProRule annotation
Disulfide bondi785 ↔ 803PROSITE-ProRule annotation
Disulfide bondi806 ↔ 815PROSITE-ProRule annotation
Disulfide bondi818 ↔ 832PROSITE-ProRule annotation
Disulfide bondi835 ↔ 849PROSITE-ProRule annotation
Disulfide bondi837 ↔ 856PROSITE-ProRule annotation
Disulfide bondi859 ↔ 868PROSITE-ProRule annotation
Disulfide bondi871 ↔ 887PROSITE-ProRule annotation
Disulfide bondi890 ↔ 909PROSITE-ProRule annotation
Disulfide bondi892 ↔ 916PROSITE-ProRule annotation
Disulfide bondi918 ↔ 927PROSITE-ProRule annotation
Disulfide bondi930 ↔ 943PROSITE-ProRule annotation
Glycosylationi936N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi946 ↔ 958PROSITE-ProRule annotation
Disulfide bondi948 ↔ 965PROSITE-ProRule annotation
Disulfide bondi967 ↔ 976PROSITE-ProRule annotation
Disulfide bondi979 ↔ 991PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1006PROSITE-ProRule annotation
Disulfide bondi996 ↔ 1013PROSITE-ProRule annotation
Disulfide bondi1015 ↔ 1024PROSITE-ProRule annotation
Disulfide bondi1027 ↔ 1038PROSITE-ProRule annotation
Glycosylationi1077N-linked (GlcNAc...)2 Publications1
Glycosylationi1183N-linked (GlcNAc...)1 Publication1
Glycosylationi1226N-linked (GlcNAc...)2 Publications1
Glycosylationi1259N-linked (GlcNAc...)2 Publications1
Glycosylationi1336N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1452N-linked (GlcNAc...)2 Publications1
Glycosylationi1528N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ18823.
PaxDbiQ18823.
PeptideAtlasiQ18823.
PRIDEiQ18823.

Expressioni

Gene expression databases

BgeeiWBGene00016913.

Interactioni

Protein-protein interaction databases

BioGridi45905. 10 interactors.
IntActiQ18823. 1 interactor.
MINTiMINT-118164.
STRINGi6239.C54D1.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ18823.
SMRiQ18823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 286Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini287 – 346Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini347 – 402Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini403 – 449Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini450 – 502Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST53
Domaini503 – 512Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini529 – 701Laminin IV type APROSITE-ProRule annotationAdd BLAST173
Domaini702 – 747Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST46
Domaini752 – 784Laminin EGF-like 6; truncatedPROSITE-ProRule annotationAdd BLAST33
Domaini785 – 834Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST50
Domaini835 – 889Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST55
Domaini890 – 945Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST56
Domaini946 – 993Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48
Domaini994 – 1040Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 11 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin IV type A domain.PROSITE-ProRule annotation
Contains 1 laminin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1836. Eukaryota.
ENOG410XRDC. LUCA.
GeneTreeiENSGT00780000121851.
HOGENOMiHOG000019301.
InParanoidiQ18823.
KOiK05635.
OMAiSCDCNGN.
OrthoDBiEOG091G005L.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000742. EGF-like_dom.
IPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR031082. Laminin_gamma.
IPR000034. Laminin_IV.
IPR008211. Laminin_N.
[Graphical view]
PANTHERiPTHR10574:SF79. PTHR10574:SF79. 3 hits.
PfamiPF00052. Laminin_B. 1 hit.
PF00053. Laminin_EGF. 10 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
SM00180. EGF_Lam. 11 hits.
SM00281. LamB. 1 hit.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 1 hit.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 10 hits.
PS51115. LAMININ_IVA. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSILWLFSL AVLWHMGQPQ PAELYPSVDP NHFGADGNPC YDRATRQPQR
60 70 80 90 100
CVPDFVNAAF NLEVQVTNTC GTKRPTKFCV QSGHTGQRSV CETCDDRHEG
110 120 130 140 150
FSHPAKYLTD FNVGNNETWW QSDTMQEGQQ YPTTTNLTLV LGKSFDITYV
160 170 180 190 200
RLKFISPRPE SFTIYKKTHT DSEWEPWQFY SGSCRATYGL SDRAPILPGN
210 220 230 240 250
EATAQCTKEF SDISPITGGN IAFSTLEGRP SAHAFEESEV LQKWVTASAI
260 270 280 290 300
RISLNRMNTF GDEVFKDPQV LRSYYYAISD FAVGGRCKCN GHASECVGSS
310 320 330 340 350
SVDGENRLVC RCEHNTQGAD CNECLPFYND RPWRSGTSVE ANECIACNCS
360 370 380 390 400
QLSNRCYFDQ QLFEETGHGG HCIDCQGNTQ GVHCEQCIAN HWRRPGENYC
410 420 430 440 450
VACGCNEIGS LSTQCDNEGK CQCKPGVTGR FCDQCLDGFY DFSTNGCKNC
460 470 480 490 500
GCETSGSLNN QPRCDSSSGS CSCKLNVEGR QCDKCKPGYF DLSTENQFGC
510 520 530 540 550
TPCFCFGHSS ICNTADGYFA MNVSSVFDQD KQKWAGQNRI GLQDTQWAEL
560 570 580 590 600
DKAVAVSDTD NSPVYFVAPE QFLGDQRSSY NQDLVFTLKV AKHVTNQDVK
610 620 630 640 650
DIIIVGADRQ ELSTSITAQG NPFPTTEAQT YRFRVHADPY FGWYPRINEL
660 670 680 690 700
DFIGILSNIT AIKIRGTYSY KDIGYLSNVN LGTAGVAPSA ANPKQATWIE
710 720 730 740 750
HCECLPGFVG QFCESCESGF RRETKFGGPF NHCIKCDCHN HSNSCEAESG
760 770 780 790 800
SCICEHNTAG DTCERCARGY YGDALQGTEE DCQKCPCPND GPCILHADGD
810 820 830 840 850
VICTECPNGY TGRRCDECSD GYFGNPKDGT ECVECACSGN TDPNSIGNCD
860 870 880 890 900
KITGECKKCI FNTHGFNCEN CKPGYWGDAL IEPKGNCQSC GCFAAGTRRP
910 920 930 940 950
NNDYTLLECN QQDGQCDCLP NVIGIQCDQC AHGFYNITSG LGCQECNCDP
960 970 980 990 1000
LGSEGNTCDV NTGQCQCKPG VTGQRCDRCA DYHFGFSANG CQPCDCEYIG
1010 1020 1030 1040 1050
SENQQCDVNS GQCLCKENVE GRRCDQCAEN RYGITQGCLP CDDCYTLIQS
1060 1070 1080 1090 1100
RVNVFREKVK SLDNTLQEII ENPAPVNDTK FDEKVKETSR AASEVWEAVK
1110 1120 1130 1140 1150
QKTKEGGGTI KTKSKAIKDE IVAALEKLTS IDESVAQAKV GADAAENDMK
1160 1170 1180 1190 1200
RWEIIIENAR REIENVLHYL ETEGEERAQI AYNASQKYGE QSKRMSELAS
1210 1220 1230 1240 1250
GTREEAEKHL KQASEIEQLS EQAIANATQA NKEASDAIYG GEQISKQIAE
1260 1270 1280 1290 1300
LKEKQNQLNE SIHRTLDLAE EQKKSADEAN NLAAVSLTNV EAVKIPSVDP
1310 1320 1330 1340 1350
KELRNDVAGV LEESENLVDS SVKENSANDE LFDEVNRSVA DARNELQSSQ
1360 1370 1380 1390 1400
DQQRVSDQLM LELEKSRERI VDSVSTADKT LKDAEAALQV LEEFGAKIEK
1410 1420 1430 1440 1450
SRNDAVAEFA GVEGINQRLD DIIDAQDKRR NSLPIDKQFV IDYRKSADVL
1460 1470 1480 1490 1500
LNETHALADR YKDIIHSDVD TRDSTEAVQY DIEQLMEELT DSNENLQYYK
1510 1520 1530 1540 1550
KQAEDDKQMA TEAVRKATLA KNSAIEANAT ILAEEDEIKK IINSLDTMEE
1560 1570 1580 1590 1600
VNNAELDELE EEIDRLDQLL AQAQLAKEVP TYQQYRADED VKVAQLKNDI
1610 1620 1630
SELQKEVLNL EEIRDNLPTK CFNVINLEQE GQK
Length:1,633
Mass (Da):181,213
Last modified:September 21, 2011 - v3
Checksum:i9480A825AED27255
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080795 Genomic DNA. Translation: CCD66855.1.
PIRiT28811.
RefSeqiNP_509204.3. NM_076803.5.
UniGeneiCel.20145.

Genome annotation databases

EnsemblMetazoaiC54D1.5.1; C54D1.5.1; WBGene00016913.
C54D1.5.2; C54D1.5.2; WBGene00016913.
GeneIDi180980.
KEGGicel:CELE_C54D1.5.
UCSCiC54D1.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080795 Genomic DNA. Translation: CCD66855.1.
PIRiT28811.
RefSeqiNP_509204.3. NM_076803.5.
UniGeneiCel.20145.

3D structure databases

ProteinModelPortaliQ18823.
SMRiQ18823.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45905. 10 interactors.
IntActiQ18823. 1 interactor.
MINTiMINT-118164.
STRINGi6239.C54D1.5.1.

Proteomic databases

EPDiQ18823.
PaxDbiQ18823.
PeptideAtlasiQ18823.
PRIDEiQ18823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC54D1.5.1; C54D1.5.1; WBGene00016913.
C54D1.5.2; C54D1.5.2; WBGene00016913.
GeneIDi180980.
KEGGicel:CELE_C54D1.5.
UCSCiC54D1.5. c. elegans.

Organism-specific databases

CTDi180980.
WormBaseiC54D1.5; CE45033; WBGene00016913; lam-2.

Phylogenomic databases

eggNOGiKOG1836. Eukaryota.
ENOG410XRDC. LUCA.
GeneTreeiENSGT00780000121851.
HOGENOMiHOG000019301.
InParanoidiQ18823.
KOiK05635.
OMAiSCDCNGN.
OrthoDBiEOG091G005L.

Miscellaneous databases

PROiQ18823.

Gene expression databases

BgeeiWBGene00016913.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR000742. EGF-like_dom.
IPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR031082. Laminin_gamma.
IPR000034. Laminin_IV.
IPR008211. Laminin_N.
[Graphical view]
PANTHERiPTHR10574:SF79. PTHR10574:SF79. 3 hits.
PfamiPF00052. Laminin_B. 1 hit.
PF00053. Laminin_EGF. 10 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 8 hits.
SM00180. EGF_Lam. 11 hits.
SM00281. LamB. 1 hit.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 8 hits.
PS01186. EGF_2. 1 hit.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 10 hits.
PS51115. LAMININ_IVA. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAM2_CAEEL
AccessioniPrimary (citable) accession number: Q18823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.