Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tubulin beta chain

Gene

ben-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

  • GTPase activity Source: UniProtKB-UniRule
  • GTP binding Source: UniProtKB-UniRule
  • structural constituent of cytoskeleton Source: InterPro
  • structural molecule activity Source: WormBase

GO - Biological processi

  • chemosensory behavior Source: WormBase
  • microtubule-based process Source: WormBase
  • oviposition Source: WormBase

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:ben-1Imported
ORF Names:C54C6.2Imported, CELE_C54C6.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC54C6.2; CE33770; WBGene00000248; ben-1.

Subcellular locationi

  • Cytoplasmcytoskeleton SAAS annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • microtubule Source: WormBase

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ18817.
PaxDbiQ18817.
PeptideAtlasiQ18817.

Expressioni

Gene expression databases

BgeeiWBGene00000248.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Protein-protein interaction databases

MINTiMINT-6669040.
STRINGi6239.C54C6.2.

Structurei

3D structure databases

ProteinModelPortaliQ18817.
SMRiQ18817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 244TubulinInterPro annotationAdd BLAST198
Domaini246 – 383Tubulin_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1375. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119061.
HOGENOMiHOG000165710.
InParanoidiQ18817.
KOiK07375.
OMAiESEYIEQ.
OrthoDBiEOG091G06U2.
PhylomeDBiQ18817.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIVHVQAG QCGNQIGAKF WEVISDEHGI QPDGTYKGES DLQLERINVY
60 70 80 90 100
YNEANGGKYV PRAVLVDLEP GTMDSVRSGP FGQLFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDNVLDVV RKEAEGCDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRIMSSFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETF
210 220 230 240 250
CIDNEALYDI CFRTLKLSNP TYGDLNHLVS VTMSGVTTCL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLSAKGAQA YRALTVAELT QQMFDAKNMM
310 320 330 340 350
AACDPRHGRY LTVAAMFRGR MSMREVDDQM MNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQEATA EEDGELDGTD GDAE
Length:444
Mass (Da):49,447
Last modified:October 1, 2003 - v3
Checksum:i4DE7E81745BB6C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAB00853.4.
PIRiT20194.
RefSeqiNP_497728.2. NM_065327.3.
UniGeneiCel.10917.

Genome annotation databases

EnsemblMetazoaiC54C6.2; C54C6.2; WBGene00000248.
GeneIDi175461.
KEGGicel:CELE_C54C6.2.

Similar proteinsi

Entry informationi

Entry nameiQ18817_CAEEL
AccessioniPrimary (citable) accession number: Q18817
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported