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Protein

Tubulin beta chain

Gene

ben-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotationSAAS annotation

GO - Molecular functioni

  • GTPase activity Source: UniProtKB-UniRule
  • GTP binding Source: UniProtKB-UniRule
  • structural constituent of cytoskeleton Source: InterPro
  • structural molecule activity Source: WormBase

GO - Biological processi

  • chemosensory behavior Source: WormBase
  • microtubule-based process Source: WormBase
  • oviposition Source: WormBase

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta chainUniRule annotation
Gene namesi
Name:ben-1Imported
ORF Names:C54C6.2Imported, CELE_C54C6.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC54C6.2 ; CE33770 ; WBGene00000248 ; ben-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonSAAS annotation, MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ18817
PaxDbiQ18817
PeptideAtlasiQ18817

Expressioni

Gene expression databases

BgeeiWBGene00000248

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Protein-protein interaction databases

STRINGi6239.C54C6.2

Structurei

3D structure databases

ProteinModelPortaliQ18817
SMRiQ18817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 244TubulinInterPro annotationAdd BLAST198
Domaini246 – 383Tubulin_CInterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili408 – 428Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061
HOGENOMiHOG000165710
InParanoidiQ18817
KOiK07375
OMAiESEYIEQ
OrthoDBiEOG091G06U2
PhylomeDBiQ18817

Family and domain databases

Gene3Di1.10.287.6001 hit
3.30.1330.201 hit
3.40.50.14401 hit
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit

Sequencei

Sequence statusi: Complete.

Q18817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIVHVQAG QCGNQIGAKF WEVISDEHGI QPDGTYKGES DLQLERINVY
60 70 80 90 100
YNEANGGKYV PRAVLVDLEP GTMDSVRSGP FGQLFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDNVLDVV RKEAEGCDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRIMSSFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETF
210 220 230 240 250
CIDNEALYDI CFRTLKLSNP TYGDLNHLVS VTMSGVTTCL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLSAKGAQA YRALTVAELT QQMFDAKNMM
310 320 330 340 350
AACDPRHGRY LTVAAMFRGR MSMREVDDQM MNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQEATA EEDGELDGTD GDAE
Length:444
Mass (Da):49,447
Last modified:October 1, 2003 - v3
Checksum:i4DE7E81745BB6C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAB00853.4
PIRiT20194
RefSeqiNP_497728.2, NM_065327.3
UniGeneiCel.10917

Genome annotation databases

EnsemblMetazoaiC54C6.2; C54C6.2; WBGene00000248
GeneIDi175461
KEGGicel:CELE_C54C6.2

Similar proteinsi

Entry informationi

Entry nameiQ18817_CAEEL
AccessioniPrimary (citable) accession number: Q18817
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2003
Last modified: February 28, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported