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Protein

Acetylcholine-gated chloride channel subunit acc-2

Gene

acc-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acetylcholine-gated chloride channel subunit. Currents in channels are triggered in response to acetylcholine. Channel properties may be modulated by the formation of homomeric and heteromeric channels.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine-gated chloride channel subunit acc-2Curated
Gene namesi
Name:acc-2Imported
ORF Names:C53D6.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC53D6.3 ; CE05488 ; WBGene00008280 ; acc-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 258ExtracellularCuratedAdd BLAST232
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 286CytoplasmicCurated7
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326ExtracellularCuratedAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 407CytoplasmicCuratedAdd BLAST60
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 445ExtracellularCuratedAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Grossly normal movement.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500418683127 – 445Acetylcholine-gated chloride channel subunit acc-2CuratedAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi59N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi121N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi162N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi177 ↔ 191By similarity
Glycosylationi218N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ18812

Expressioni

Tissue specificityi

Expressed in RIA, RIG, PHA and AIZ glutamatergic neurons, URX and RIH cholinergic neurons, and in male-specific MCM neurons.1 Publication

Gene expression databases

BgeeiWBGene00008280

Interactioni

Subunit structurei

Homopentamer (in vitro). May interact with either acc-3 or acc-4; the interactions do not result in significant heteropentameric ion channel activity.1 Publication

Protein-protein interaction databases

STRINGi6239.C53D6.3

Structurei

3D structure databases

ProteinModelPortaliQ18812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3644 Eukaryota
ENOG410XP43 LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000016259
InParanoidiQ18812
OMAiIYITETW
OrthoDBiEOG091G07NS
PhylomeDBiQ18812

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFTLLSTLP VLIITTELDY SELVHSAELV SSSSYIHHKT NKKPDNCTRD
60 70 80 90 100
TDIIDRLLNG TGYNKFRIPQ EEGMTVVVEI WIQAITSIDE LTNDFDMDIY
110 120 130 140 150
ITETWLDPAL NFQTMTPCKG NLSLNHQVLD RLWTPNSCFI NSKVAQIHNS
160 170 180 190 200
PFRSVFLMLF PNGTVMVNYR VRVKGPCSLD LSNFPLDLQK CSLIYESFNY
210 220 230 240 250
NRQEVEMRWS DAEHPVFNLS KIMLPDFDLF EIQTERRQEP YPAGMWDELH
260 270 280 290 300
VTIIFERRFI WYFMQAYLPT YLTIFISWIS FSLGSRAIPA RTMLGVNSLL
310 320 330 340 350
AIVFSFGNIM RNLPRVSYIK GIDVWMLVSM TFIFCSLLEL AIVGFMVRDE
360 370 380 390 400
TVAKKKQQKK ISGNISREES PHGIISERRF MFPPGCSESS KSLSSCTSGW
410 420 430 440
TPERIDSISS VMFPFSFFVF NIIYWFYYIH RKEIIKQNLI NRVDG
Length:445
Mass (Da):51,686
Last modified:November 1, 1996 - v1
Checksum:i3F60AE853A50F4FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CAA94228.1
PIRiT20190
RefSeqiNP_501567.1, NM_069166.1
UniGeneiCel.13246

Genome annotation databases

EnsemblMetazoaiC53D6.3; C53D6.3; WBGene00008280
GeneIDi183758
KEGGicel:CELE_C53D6.3
UCSCiC53D6.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiACC2_CAEEL
AccessioniPrimary (citable) accession number: Q18812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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