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Protein
Submitted name:

Acetylcholine-gated Chloride Channel

Gene

acc-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine-gated Chloride ChannelImported
Gene namesi
Name:acc-2Imported
ORF Names:C53D6.3Imported, CELE_C53D6.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC53D6.3; CE05488; WBGene00008280; acc-2.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei259 – 28123HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31018HelicalSequence analysisAdd
BLAST
Transmembranei322 – 34726HelicalSequence analysisAdd
BLAST
Transmembranei411 – 42919HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 445419Sequence analysisPRO_5004186831Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ18812.
PRIDEiQ18812.

Interactioni

Protein-protein interaction databases

STRINGi6239.C53D6.3.

Structurei

3D structure databases

ProteinModelPortaliQ18812.
SMRiQ18812. Positions 50-433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 258208Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini267 – 35791Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000016259.
InParanoidiQ18812.
OMAiIYITETW.
OrthoDBiEOG779P2M.
PhylomeDBiQ18812.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFTLLSTLP VLIITTELDY SELVHSAELV SSSSYIHHKT NKKPDNCTRD
60 70 80 90 100
TDIIDRLLNG TGYNKFRIPQ EEGMTVVVEI WIQAITSIDE LTNDFDMDIY
110 120 130 140 150
ITETWLDPAL NFQTMTPCKG NLSLNHQVLD RLWTPNSCFI NSKVAQIHNS
160 170 180 190 200
PFRSVFLMLF PNGTVMVNYR VRVKGPCSLD LSNFPLDLQK CSLIYESFNY
210 220 230 240 250
NRQEVEMRWS DAEHPVFNLS KIMLPDFDLF EIQTERRQEP YPAGMWDELH
260 270 280 290 300
VTIIFERRFI WYFMQAYLPT YLTIFISWIS FSLGSRAIPA RTMLGVNSLL
310 320 330 340 350
AIVFSFGNIM RNLPRVSYIK GIDVWMLVSM TFIFCSLLEL AIVGFMVRDE
360 370 380 390 400
TVAKKKQQKK ISGNISREES PHGIISERRF MFPPGCSESS KSLSSCTSGW
410 420 430 440
TPERIDSISS VMFPFSFFVF NIIYWFYYIH RKEIIKQNLI NRVDG
Length:445
Mass (Da):51,686
Last modified:November 1, 1996 - v1
Checksum:i3F60AE853A50F4FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA94228.1.
PIRiT20190.
RefSeqiNP_501567.1. NM_069166.1.
UniGeneiCel.13246.

Genome annotation databases

EnsemblMetazoaiC53D6.3; C53D6.3; WBGene00008280.
GeneIDi183758.
KEGGicel:CELE_C53D6.3.
UCSCiC53D6.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA94228.1.
PIRiT20190.
RefSeqiNP_501567.1. NM_069166.1.
UniGeneiCel.13246.

3D structure databases

ProteinModelPortaliQ18812.
SMRiQ18812. Positions 50-433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C53D6.3.

Proteomic databases

PaxDbiQ18812.
PRIDEiQ18812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC53D6.3; C53D6.3; WBGene00008280.
GeneIDi183758.
KEGGicel:CELE_C53D6.3.
UCSCiC53D6.3. c. elegans.

Organism-specific databases

CTDi183758.
WormBaseiC53D6.3; CE05488; WBGene00008280; acc-2.

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000016259.
InParanoidiQ18812.
OMAiIYITETW.
OrthoDBiEOG779P2M.
PhylomeDBiQ18812.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ18812_CAEEL
AccessioniPrimary (citable) accession number: Q18812
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.