Q187E4 (Q187E4_CLOD6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase HAMAP MF_00110
EC=4.2.3.4 HAMAP MF_00110

Gene names

Name:	aroB HAMAP MF_00110 EMBL CAJ68704.1
Ordered Locus Names:	CD630_18330

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family. HAMAP MF_00110

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00110
Cellular component	Cytoplasm HAMAP MF_00110
Ligand	NAD HAMAP MF_00110
Molecular function	Lyase HAMAP MF_00110 EMBL CAJ68704.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q187E4 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 03CD20AC5472CC34	FASTA	354	40,053
	10 20 30 40 50 60 MEEKLLVNLK ENSYNIFIKK NILKNIGEEI KKIYFGNKIF IVTDENIAKL YLDKVKNNLS 70 80 90 100 110 120 ESGFEIKSLI LKSGEETKSF NTLPKIYDSL LDFKLTRKDL IITLGGGVIG DLGGFAAATF 130 140 150 160 170 180 LRGISFIQIP TSLLAQVDSS VGGKVGVDLE RGKNLVGSFY QPKAVFIDPN VLLSLPEKFY 190 200 210 220 230 240 RDGMAEVIKY GCIKDKTFFN KLLSLKNREE VMQHIEYIIH KCCFIKKTVV EADEKDFGDR 250 260 270 280 290 300 MLLNFGHTLG HAIEKYYNFT GYTHGEAVAI GMYKITLESE KIGITKKGTS ELIKSILMNY 310 320 330 340 350 NLPYEIELRD NKSIVDAISL DKKNLGDTLK IILLKDIGES IIYNTTSKFF QEVR

References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome." Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T. , Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J. Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 630.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180355 Genomic DNA. Translation: CAJ68704.1.
RefSeq	YP_001088339.1. NC_009089.1.
3D structure databases
ProteinModelPortal	Q187E4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q187E4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4914601.
GenomeReviews	Gene locus CD1833 in contig AM180355_GR.
KEGG	cdf:CD1833.
NMPDR	fig|1496.1.peg.2971.
PATRIC	19442075. VBICloDif38397_1924.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0337.
HOGENOM	HBG632303.
OMA	LGQSDFT.
ProtClustDB	PRK00002.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q187E4_CLOD6

Accession

Primary (citable) accession number: Q187E4

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)