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Protein

26S proteasome regulatory subunit 7

Gene

rpt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 7
Alternative name(s):
26S proteasome AAA-ATPase subunit rpt-1
Proteasome 26S subunit ATPase 2
Gene namesi
Name:rpt-1
ORF Names:C52E4.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC52E4.4; CE08946; WBGene00004501; rpt-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847131 – 43526S proteasome regulatory subunit 7Add BLAST435

Proteomic databases

EPDiQ18787.
PaxDbiQ18787.
PeptideAtlasiQ18787.
PRIDEiQ18787.

Expressioni

Gene expression databases

BgeeiWBGene00004501.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_F35G12.12Q200586EBI-318033,EBI-318041

GO - Molecular functioni

Protein-protein interaction databases

BioGridi44665. 1 interactor.
IntActiQ18787. 2 interactors.
MINTiMINT-212537.
STRINGi6239.C52E4.4.2.

Structurei

3D structure databases

ProteinModelPortaliQ18787.
SMRiQ18787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0729. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074978.
HOGENOMiHOG000225143.
InParanoidiQ18787.
KOiK03061.
OMAiNKYQIHL.
OrthoDBiEOG091G096W.
PhylomeDBiQ18787.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45-like.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035245. PSMC2.
PANTHERiPTHR23073:SF13. PTHR23073:SF13. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDHLGDDMR KTKKDDTKEE EKNFQALDEG DIAVLKRYGQ GPYAEQLKTL
60 70 80 90 100
DADIENCLKK VNELSGVKES DTGLAPPALW DIAADKQAMQ QEQPLQVARC
110 120 130 140 150
TKIITSDKHD PRYLINVKQF AKFVVDLADS VAPTDIEEGM RVGVDRNKYQ
160 170 180 190 200
IHLPLPAKID PTVTMMQVEE KPDVTYSDVG GCKDQIEKLR EVVETPLLHP
210 220 230 240 250
ERYVNLGIEP PKGVLLYGPP GTGKTLCARA VANRTDACFI RVIGSELVQK
260 270 280 290 300
YVGEGARMVR ELFEMARTKK ACLIFFDEID AVGGARFDDG QGGDNEVQRT
310 320 330 340 350
MLELINQLDG FDPRGNIKVL MATNRPDTLD PALMRPGRLD RKVEFALPDL
360 370 380 390 400
AGRAHILKIH AKQMSVERDI RYDLLARLCP NSTGAEIRSV CTEAGMFAIR
410 420 430
ARRKVATEKD FLEAINKVVK GYAKFSATPR YLTHN
Length:435
Mass (Da):48,611
Last modified:November 1, 1997 - v1
Checksum:i51D54DD6DEF923B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78012 Genomic DNA. Translation: CAB01414.1.
PIRiT20152.
RefSeqiNP_506005.1. NM_073604.5.
UniGeneiCel.6852.

Genome annotation databases

EnsemblMetazoaiC52E4.4.1; C52E4.4.1; WBGene00004501.
C52E4.4.2; C52E4.4.2; WBGene00004501.
GeneIDi179641.
KEGGicel:CELE_C52E4.4.
UCSCiC52E4.4.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPRS7_CAEEL
AccessioniPrimary (citable) accession number: Q18787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 22, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families