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Protein

26S proteasome regulatory subunit 7

Gene

rpt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi218 – 225ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 7
Alternative name(s):
26S proteasome AAA-ATPase subunit rpt-1
Proteasome 26S subunit ATPase 2
Gene namesi
Name:rpt-1
ORF Names:C52E4.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC52E4.4 ; CE08946 ; WBGene00004501 ; rpt-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847131 – 43526S proteasome regulatory subunit 7Add BLAST435

Proteomic databases

EPDiQ18787
PaxDbiQ18787
PeptideAtlasiQ18787
PRIDEiQ18787

Expressioni

Gene expression databases

BgeeiWBGene00004501

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_F35G12.12Q200586EBI-318033,EBI-318041

GO - Molecular functioni

Protein-protein interaction databases

BioGridi44665, 1 interactor
IntActiQ18787, 2 interactors
STRINGi6239.C52E4.4.2

Structurei

3D structure databases

ProteinModelPortaliQ18787
SMRiQ18787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0729 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074978
HOGENOMiHOG000225143
InParanoidiQ18787
KOiK03061
OMAiNKYQIHL
OrthoDBiEOG091G096W
PhylomeDBiQ18787

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035245 PSMC2
PANTHERiPTHR23073:SF13 PTHR23073:SF13, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q18787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDHLGDDMR KTKKDDTKEE EKNFQALDEG DIAVLKRYGQ GPYAEQLKTL
60 70 80 90 100
DADIENCLKK VNELSGVKES DTGLAPPALW DIAADKQAMQ QEQPLQVARC
110 120 130 140 150
TKIITSDKHD PRYLINVKQF AKFVVDLADS VAPTDIEEGM RVGVDRNKYQ
160 170 180 190 200
IHLPLPAKID PTVTMMQVEE KPDVTYSDVG GCKDQIEKLR EVVETPLLHP
210 220 230 240 250
ERYVNLGIEP PKGVLLYGPP GTGKTLCARA VANRTDACFI RVIGSELVQK
260 270 280 290 300
YVGEGARMVR ELFEMARTKK ACLIFFDEID AVGGARFDDG QGGDNEVQRT
310 320 330 340 350
MLELINQLDG FDPRGNIKVL MATNRPDTLD PALMRPGRLD RKVEFALPDL
360 370 380 390 400
AGRAHILKIH AKQMSVERDI RYDLLARLCP NSTGAEIRSV CTEAGMFAIR
410 420 430
ARRKVATEKD FLEAINKVVK GYAKFSATPR YLTHN
Length:435
Mass (Da):48,611
Last modified:November 1, 1997 - v1
Checksum:i51D54DD6DEF923B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78012 Genomic DNA Translation: CAB01414.1
PIRiT20152
RefSeqiNP_506005.1, NM_073604.5
UniGeneiCel.6852

Genome annotation databases

EnsemblMetazoaiC52E4.4.1; C52E4.4.1; WBGene00004501
C52E4.4.2; C52E4.4.2; WBGene00004501
GeneIDi179641
KEGGicel:CELE_C52E4.4
UCSCiC52E4.4.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPRS7_CAEEL
AccessioniPrimary (citable) accession number: Q18787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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