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Protein
Submitted name:

Uncharacterized protein

Gene

mec-9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of touch Source: UniProtKB
  • mechanosensory behavior Source: WormBase
  • positive regulation of detection of mechanical stimulus involved in sensory perception of touch Source: UniProtKB
  • positive regulation of mechanosensory behavior Source: UniProtKB
  • response to mechanical stimulus Source: WormBase

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:mec-9Imported
ORF Names:C50H2.3Imported, CELE_C50H2.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC50H2.3a; CE05481; WBGene00003173; mec-9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500418689923 – 838Sequence analysisAdd BLAST816

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi558 ↔ 575PROSITE-ProRule annotation
Disulfide bondi577 ↔ 586PROSITE-ProRule annotation
Disulfide bondi644 ↔ 661PROSITE-ProRule annotation
Disulfide bondi663 ↔ 672PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ18761.

Expressioni

Gene expression databases

BgeeiWBGene00003173.
ExpressionAtlasiQ18761. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.C50H2.3a.

Structurei

3D structure databases

ProteinModelPortaliQ18761.
SMRiQ18761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 86BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini100 – 153BPTI/Kunitz inhibitorInterPro annotationAdd BLAST54
Domaini199 – 239EGF-likeInterPro annotationAdd BLAST41
Domaini279 – 319EGF-likeInterPro annotationAdd BLAST41
Domaini325 – 381BPTI/Kunitz inhibitorInterPro annotationAdd BLAST57
Domaini393 – 449BPTI/Kunitz inhibitorInterPro annotationAdd BLAST57
Domaini460 – 516BPTI/Kunitz inhibitorInterPro annotationAdd BLAST57
Domaini548 – 587EGF-likeInterPro annotationAdd BLAST40
Domaini591 – 632EGF-likeInterPro annotationAdd BLAST42
Domaini635 – 673EGF-likeInterPro annotationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili759 – 813Sequence analysisAdd BLAST55

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000021660.
InParanoidiQ18761.
OMAiKCECMAS.
OrthoDBiEOG091G0201.
PhylomeDBiQ18761.

Family and domain databases

CDDicd00109. KU. 2 hits.
Gene3Di4.10.410.10. 5 hits.
InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR020901. Prtase_inh_Kunz-CS.
PfamiView protein in Pfam
PF00008. EGF. 3 hits.
PF07645. EGF_CA. 2 hits.
PF00014. Kunitz_BPTI. 5 hits.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 5 hits.
SM00131. KU. 5 hits.
SUPFAMiSSF57362. SSF57362. 5 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 2 hits.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 5 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

Q18761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLPPPHKLF PFFLVFLNLV DTKDEPVFVK NNEDICLEDV DPGPCQYYQV
60 70 80 90 100
QWFWDKQVEE CKEFHYGGCM GTKNRFSSKQ QCVKQCKYKM FNPVAVPDLC
110 120 130 140 150
LLDADQGHCG DERNGHWWYF FNQESGECEK FFYYGCGGND NKFYSLHMCR
160 170 180 190 200
KVCGERLSPQ IACDHCDLRT SFCKSNSKFN YTCECRSGYE KNQYGECIDI
210 220 230 240 250
DECRGYKAVC DRNAWCVNEI GSYKCECMAS YRGDGKHCTY VGLGRSSIDC
260 270 280 290 300
KDCSMHATCM NGVCQCKEGY EGDGFNCTDV NECLRRPEMC NKNAECINRE
310 320 330 340 350
GSFICTCLEG YAGNGYNCTV SKNSCLDKFD HDYKDTCGNE NWRPHFFFNH
360 370 380 390 400
QTRMCEQFWY DGCRGRSRNI FSEYDTCTTM CEETNVLTRA EVCWDKFDMN
410 420 430 440 450
YRNQCMNGQW QQRYYFDHAS LTCRQFWFDG CRSDSRNIFD DELTCQWLCE
460 470 480 490 500
SQPMYKSRSC LEDFDEGLKK ECNGGRWRHQ WYFDKGSKKC FSFWYDGCKG
510 520 530 540 550
ANENIFQDEL SCLHTCENPA KKDPKKPWHN NDKFKMKEII GDIYKPNLTD
560 570 580 590 600
TCLAKNPCKN NGTCIFVWKK DTHYCKCQPG FHGNNCDKVV DYDPCAEKPC
610 620 630 640 650
LNGATCQIKY NDDDVDEKPT FECFCAAGFG GPKCDQRPCE SNPCLNNGTC
660 670 680 690 700
RTTKGYSTYF CECANGFGGK NCDVSIGNTP PEEKFGKNVE QISSGKEEWI
710 720 730 740 750
AQMRQRLKET GGGIGGASGS GLKSENGTMG GSSGEKSGEK KSGKNKKSKA
760 770 780 790 800
TQVADEPYKD PATRKREREE REKKEAEIQA AEEEEKQRKE YEEDAQRKKA
810 820 830
EEMELEAKKA LEAANFGLKT DFSMSLLTIL MAFVLREF
Length:838
Mass (Da):96,396
Last modified:November 1, 1996 - v1
Checksum:iDB6476CCD29AA7C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAA98251.1.
PIRiT20125.
RefSeqiNP_001256153.1. NM_001269224.1.
UniGeneiCel.2950.

Genome annotation databases

EnsemblMetazoaiC50H2.3a; C50H2.3a; WBGene00003173.
GeneIDi179382.
KEGGicel:CELE_C50H2.3.

Similar proteinsi

Entry informationi

Entry nameiQ18761_CAEEL
AccessioniPrimary (citable) accession number: Q18761
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported