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Protein
Submitted name:

Uncharacterized protein

Gene

mec-9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • mechanosensory behavior Source: WormBase
  • response to mechanical stimulus Source: WormBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:mec-9Imported
ORF Names:C50H2.3Imported, CELE_C50H2.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC50H2.3a; CE05481; WBGene00003173; mec-9.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 838816Sequence analysisPRO_5004186899Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ18761.
PRIDEiQ18761.

Expressioni

Gene expression databases

ExpressionAtlasiQ18761. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.C50H2.3a.

Structurei

3D structure databases

ProteinModelPortaliQ18761.
SMRiQ18761. Positions 34-159, 199-314, 512-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 8651BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini100 – 15354BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini199 – 23941EGF-likeInterPro annotationAdd
BLAST
Domaini279 – 31941EGF-likeInterPro annotationAdd
BLAST
Domaini325 – 38157BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini393 – 44957BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini460 – 51657BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST
Domaini548 – 58740EGF-likeInterPro annotationAdd
BLAST
Domaini591 – 63242EGF-likeInterPro annotationAdd
BLAST
Domaini635 – 67339EGF-likeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili759 – 81355Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 5 BPTI/Kunitz inhibitor domains.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000021660.
InParanoidiQ18761.
OMAiKCECMAS.
OrthoDBiEOG73FQKT.
PhylomeDBiQ18761.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
4.10.410.10. 5 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP-like.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF07645. EGF_CA. 2 hits.
PF00014. Kunitz_BPTI. 5 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00181. EGF. 7 hits.
SM00179. EGF_CA. 5 hits.
SM00131. KU. 5 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 5 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLPPPHKLF PFFLVFLNLV DTKDEPVFVK NNEDICLEDV DPGPCQYYQV
60 70 80 90 100
QWFWDKQVEE CKEFHYGGCM GTKNRFSSKQ QCVKQCKYKM FNPVAVPDLC
110 120 130 140 150
LLDADQGHCG DERNGHWWYF FNQESGECEK FFYYGCGGND NKFYSLHMCR
160 170 180 190 200
KVCGERLSPQ IACDHCDLRT SFCKSNSKFN YTCECRSGYE KNQYGECIDI
210 220 230 240 250
DECRGYKAVC DRNAWCVNEI GSYKCECMAS YRGDGKHCTY VGLGRSSIDC
260 270 280 290 300
KDCSMHATCM NGVCQCKEGY EGDGFNCTDV NECLRRPEMC NKNAECINRE
310 320 330 340 350
GSFICTCLEG YAGNGYNCTV SKNSCLDKFD HDYKDTCGNE NWRPHFFFNH
360 370 380 390 400
QTRMCEQFWY DGCRGRSRNI FSEYDTCTTM CEETNVLTRA EVCWDKFDMN
410 420 430 440 450
YRNQCMNGQW QQRYYFDHAS LTCRQFWFDG CRSDSRNIFD DELTCQWLCE
460 470 480 490 500
SQPMYKSRSC LEDFDEGLKK ECNGGRWRHQ WYFDKGSKKC FSFWYDGCKG
510 520 530 540 550
ANENIFQDEL SCLHTCENPA KKDPKKPWHN NDKFKMKEII GDIYKPNLTD
560 570 580 590 600
TCLAKNPCKN NGTCIFVWKK DTHYCKCQPG FHGNNCDKVV DYDPCAEKPC
610 620 630 640 650
LNGATCQIKY NDDDVDEKPT FECFCAAGFG GPKCDQRPCE SNPCLNNGTC
660 670 680 690 700
RTTKGYSTYF CECANGFGGK NCDVSIGNTP PEEKFGKNVE QISSGKEEWI
710 720 730 740 750
AQMRQRLKET GGGIGGASGS GLKSENGTMG GSSGEKSGEK KSGKNKKSKA
760 770 780 790 800
TQVADEPYKD PATRKREREE REKKEAEIQA AEEEEKQRKE YEEDAQRKKA
810 820 830
EEMELEAKKA LEAANFGLKT DFSMSLLTIL MAFVLREF
Length:838
Mass (Da):96,396
Last modified:November 1, 1996 - v1
Checksum:iDB6476CCD29AA7C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAA98251.1.
PIRiT20125.
RefSeqiNP_001256153.1. NM_001269224.1.
UniGeneiCel.2950.

Genome annotation databases

EnsemblMetazoaiC50H2.3a; C50H2.3a; WBGene00003173.
GeneIDi179382.
KEGGicel:CELE_C50H2.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAA98251.1.
PIRiT20125.
RefSeqiNP_001256153.1. NM_001269224.1.
UniGeneiCel.2950.

3D structure databases

ProteinModelPortaliQ18761.
SMRiQ18761. Positions 34-159, 199-314, 512-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C50H2.3a.

Proteomic databases

PaxDbiQ18761.
PRIDEiQ18761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC50H2.3a; C50H2.3a; WBGene00003173.
GeneIDi179382.
KEGGicel:CELE_C50H2.3.

Organism-specific databases

CTDi179382.
WormBaseiC50H2.3a; CE05481; WBGene00003173; mec-9.

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000021660.
InParanoidiQ18761.
OMAiKCECMAS.
OrthoDBiEOG73FQKT.
PhylomeDBiQ18761.

Gene expression databases

ExpressionAtlasiQ18761. baseline.

Family and domain databases

Gene3Di2.40.155.10. 1 hit.
4.10.410.10. 5 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP-like.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF07645. EGF_CA. 2 hits.
PF00014. Kunitz_BPTI. 5 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00181. EGF. 7 hits.
SM00179. EGF_CA. 5 hits.
SM00131. KU. 5 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 5 hits.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ18761_CAEEL
AccessioniPrimary (citable) accession number: Q18761
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.