Adenosine deaminase - Clostridium difficile (strain 630)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Adenosine deaminase HAMAP MF_00540
EC=3.5.4.4 HAMAP MF_00540

Alternative name(s):
Adenosine aminohydrolase HAMAP MF_00540

Gene names

Name:	add HAMAP MF_00540 EMBL CAJ68615.1
Ordered Locus Names:	CD630_17470

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenosine + H₂O = inosine + NH₃. HAMAP MF_00540
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540 SAAS SAAS006330
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. HAMAP MF_00540

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00540 SAAS SAAS006330
Ligand	Metal-binding HAMAP MF_00540 SAAS SAAS006330 Zinc HAMAP MF_00540 SAAS SAAS006330
Molecular function	Hydrolase HAMAP MF_00540 SAAS SAAS006330 EMBL CAJ68615.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Active site

199

1

Proton donor By similarity HAMAP MF_00540

Metal binding

11

1

Zinc; catalytic By similarity HAMAP MF_00540

Metal binding

13

1

Zinc; catalytic By similarity HAMAP MF_00540

Metal binding

196

1

Zinc; catalytic By similarity HAMAP MF_00540

Metal binding

277

1

Zinc; catalytic By similarity HAMAP MF_00540

Binding site

13

1

Substrate By similarity HAMAP MF_00540

Binding site

15

1

Substrate By similarity HAMAP MF_00540

Binding site

169

1

Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00540

Site

220

1

Important for catalytic activity By similarity HAMAP MF_00540

Sequences

Sequence

Length

Mass (Da)

Tools

Q186V5 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: E9612DA5DAA28E96
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FASTA

329

37,417

        10         20         30         40         50         60 
MFENLPKIDL HCHLDGSVRV ETMLDIAIKE KIDLPSNNMD EIKKLAKVSF NCTSLDEYLE 

        70         80         90        100        110        120 
KFDLPLKVMQ SKENLKRITF ELLEDASREN VKYIEIRFAP LLHTQKGMSV KNIIEGIIEG 

       130        140        150        160        170        180 
IREAESIYDI KGNLILGCMR TMTSKEALLV IEEGKSFVNK GVVAVDLCGP EKEGFCKEYK 

       190        200        210        220        230        240 
DVFKLAREYG YKVTIHAGEA ASGENVLDAI NILKADRIGH GVKIKDHKKA YNLVKDKKIL 

       250        260        270        280        290        300 
LELCPTSNVQ TKTVDSYEAH PFYTFYKDNL HVSINTDNRT VSDINLSSEL NVIFDTFKLG 

       310        320 
LEDYKIIYRN AVEASFADKE TKEYLNSLI

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References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome."
Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T.

Parkhill J.
Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 630.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180355 Genomic DNA. Translation: CAJ68615.1.
RefSeq	YP_001088251.1. NC_009089.1.
3D structure databases
ProteinModelPortal	Q186V5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q186V5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4913234.
GenomeReviews	Gene locus CD1747 in contig AM180355_GR.
KEGG	cdf:CD1747.
NMPDR	fig\|1496.1.peg.1618.
PATRIC	19441889. VBICloDif38397_1831.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1816.
HOGENOM	HBG630382.
OMA	CKKYQQQ.
ProtClustDB	PRK09358.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q186V5_CLOD6

Accession

Primary (citable) accession number: Q186V5

Entry history

Integrated into UniProtKB/TrEMBL:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information