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Protein

Superoxide dismutase

Gene

sodA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Divalent metal cationUniRule annotation1
Metal bindingi56Iron; via tele nitrogenCombined sources1
Metal bindingi56Manganese; via tele nitrogenCombined sources1
Metal bindingi111Divalent metal cationUniRule annotation1
Metal bindingi111Iron; via tele nitrogenCombined sources1
Metal bindingi111Manganese; via tele nitrogenCombined sources1
Metal bindingi193Divalent metal cationUniRule annotation1
Metal bindingi193IronCombined sources1
Metal bindingi193ManganeseCombined sources1
Metal bindingi197Divalent metal cationUniRule annotation1
Metal bindingi197Iron; via tele nitrogenCombined sources1
Metal bindingi197Manganese; via tele nitrogenCombined sources1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandIronCombined sources, ManganeseCombined sources, Metal-bindingUniRule annotationCombined sources

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1770-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodAImported
Ordered Locus Names:CD630_16310Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Capsid proteinImported, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500418688125 – 234Superoxide dismutaseSequence analysisAdd BLAST210

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1631

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TJTX-ray1.80A27-234[»]
4JYYX-ray2.10A27-234[»]
4JZ2X-ray1.95A27-234[»]
4JZGX-ray2.32A27-234[»]
ProteinModelPortaliQ186I6
SMRiQ186I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 118Sod_Fe_NInterPro annotationAdd BLAST88
Domaini125 – 223Sod_Fe_CInterPro annotationAdd BLAST99

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013584
KOiK04564
OMAiKWGSFDK

Family and domain databases

Gene3Di1.10.287.9901 hit
2.40.500.201 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Q186I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKILIPVI MSLFIISQCI TSFAFTPENN KFKVKPLPYA YDALEPYIDK
60 70 80 90 100
ETMKLHHDKH YQAYVDKLNA ALEKYPELYN YSLCELLQNL DSLPKDIATT
110 120 130 140 150
VRNNAGGAYN HKFFFDIMTP EKTIPSESLK EAIDRDFGSF EKFKQEFQKS
160 170 180 190 200
ALDVFGSGWA WLVATKDGKL SIMTTPNQDS PVSKNLTPII GLDVWEHAYY
210 220 230
LKYQNRRNEY IDNWFNVVNW NGALENYKNL KSQD
Length:234
Mass (Da):27,206
Last modified:July 25, 2006 - v1
Checksum:iE26DF02D360B245B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ68496.1
RefSeqiWP_009889536.1, NZ_CP010905.2
YP_001088132.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ68496; CAJ68496; CD630_16310
GeneIDi31353230
4915629
KEGGicdf:CD630_16310
pdc:CDIF630_01808
PATRICifig|272563.120.peg.1709

Similar proteinsi

Entry informationi

Entry nameiQ186I6_PEPD6
AccessioniPrimary (citable) accession number: Q186I6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported