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Protein

Superoxide dismutase

Gene

sodA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Iron; via tele nitrogenCombined sources1
Metal bindingi56Manganese; via tele nitrogenCombined sources1
Metal bindingi111Iron; via tele nitrogenCombined sources1
Metal bindingi111Manganese; via tele nitrogenCombined sources1
Metal bindingi193IronCombined sources1
Metal bindingi193ManganeseCombined sources1
Metal bindingi197Iron; via tele nitrogenCombined sources1
Metal bindingi197Manganese; via tele nitrogenCombined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

IronCombined sources, ManganeseCombined sources, Metal-bindingUniRule annotationCombined sources

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodAImported
Ordered Locus Names:CD630_16310Imported
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)Imported
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinImported, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500418688125 – 234Superoxide dismutaseSequence analysisAdd BLAST210

Interactioni

Protein-protein interaction databases

STRINGi272563.CD1631.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TJTX-ray1.80A27-234[»]
4JYYX-ray2.10A27-234[»]
4JZ2X-ray1.95A27-234[»]
4JZGX-ray2.32A27-234[»]
ProteinModelPortaliQ186I6.
SMRiQ186I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 118Sod_Fe_NInterPro annotationAdd BLAST88
Domaini125 – 223Sod_Fe_CInterPro annotationAdd BLAST99

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013584.
KOiK04564.
OMAiAKTQFAS.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q186I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKILIPVI MSLFIISQCI TSFAFTPENN KFKVKPLPYA YDALEPYIDK
60 70 80 90 100
ETMKLHHDKH YQAYVDKLNA ALEKYPELYN YSLCELLQNL DSLPKDIATT
110 120 130 140 150
VRNNAGGAYN HKFFFDIMTP EKTIPSESLK EAIDRDFGSF EKFKQEFQKS
160 170 180 190 200
ALDVFGSGWA WLVATKDGKL SIMTTPNQDS PVSKNLTPII GLDVWEHAYY
210 220 230
LKYQNRRNEY IDNWFNVVNW NGALENYKNL KSQD
Length:234
Mass (Da):27,206
Last modified:July 25, 2006 - v1
Checksum:iE26DF02D360B245B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68496.1.
RefSeqiWP_009889536.1. NZ_CP010905.1.
YP_001088132.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ68496; CAJ68496; CD630_16310.
GeneIDi4915629.
KEGGicdf:CD630_16310.
pdc:CDIF630_01808.
PATRICi19441641. VBICloDif38397_1708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ68496.1.
RefSeqiWP_009889536.1. NZ_CP010905.1.
YP_001088132.1. NC_009089.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TJTX-ray1.80A27-234[»]
4JYYX-ray2.10A27-234[»]
4JZ2X-ray1.95A27-234[»]
4JZGX-ray2.32A27-234[»]
ProteinModelPortaliQ186I6.
SMRiQ186I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD1631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ68496; CAJ68496; CD630_16310.
GeneIDi4915629.
KEGGicdf:CD630_16310.
pdc:CDIF630_01808.
PATRICi19441641. VBICloDif38397_1708.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013584.
KOiK04564.
OMAiAKTQFAS.

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-1770-MONOMER.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ186I6_PEPD6
AccessioniPrimary (citable) accession number: Q186I6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.