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Q186F4 (THIM_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:CD630_16000
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceae

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000336550

Sites

Binding site401Substrate; via amide nitrogen By similarity
Binding site1161ATP By similarity
Binding site1621ATP By similarity
Binding site1891Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q186F4 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 5E891DE5374BA09D

FASTA26228,291
        10         20         30         40         50         60 
MYNLIKDVKK LNPLVIHYTN NVTINDCANV TLAVGASPLM SFSYEEVEEM VSVANSVVIN 

        70         80         90        100        110        120 
IGTMNSNMLD LFLLAGKAAN KYNKPVVLDP VGVFASKARA ELTSRLLNEV KFSVVKGNVS 

       130        140        150        160        170        180 
EIKFIGGFNV RGKGVDSFDE EEDSTEIIRK IAEKLECVVV ATGKIDIITN GKGTYKINNG 

       190        200        210        220        230        240 
TDKLKGITGT GCMTASLIAS FMAVTENILE AATMGVLTMS LSGELANLNN PPIGTFKENL 

       250        260 
MNAIYQMDID ALSKNSNIEF LN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ68465.1.
RefSeqYP_001088101.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ186F4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD1600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ68465; CAJ68465; CD630_16000.
GeneID4913385.
KEGGcdf:CD630_16000.
PATRIC19441579. VBICloDif38397_1677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAFDENIEM.
OrthoDBEOG628F8M.
ProtClustDBCLSK2534955.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-1776-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_CLOD6
AccessionPrimary (citable) accession number: Q186F4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 25, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways