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Q186A6 (AROD_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:CD630_22170
OrganismClostridium difficile (strain 630) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214

Subunit structure

Homodimer By similarity. HAMAP MF_00214

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2552553-dehydroquinate dehydratase HAMAP MF_00214
PRO_0000325520

Sites

Active site1441Proton acceptor By similarity
Active site1711Schiff-base intermediate with substrate By similarity

Secondary structure

1 ...................................... 255
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q186A6 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: 60B9943466E5C9AD

FASTA25528,876
        10         20         30         40         50         60 
MKRKVQVKNI TIGEGRPKIC VPIIGKNKKD IIKEAKELKD ACLDIIEWRV DFFENVENIK 

        70         80         90        100        110        120 
EVKEVLYELR SYIHDIPLLF TFRSVVEGGE KLISRDYYTT LNKEISNTGL VDLIDVELFM 

       130        140        150        160        170        180 
GDEVIDEVVN FAHKKEVKVI ISNHDFNKTP KKEEIVSRLC RMQELGADLP KIAVMPQNEK 

       190        200        210        220        230        240 
DVLVLLEATN EMFKIYADRP IITMSMSGMG VISRLCGEIF GSALTFGAAK SVSAPGQISF 

       250 
KELNSVLNLL HKSIN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM180355 Genomic DNA. Translation: CAJ69102.2.
RefSeqYP_001088731.1. NC_009089.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3JS3X-ray2.20A/B/C/D1-255[»]
ProteinModelPortalQ186A6.
SMRQ186A6. Positions 3-253.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ186A6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4914552.
GenomeReviewsGene locus CD2217 in contig AM180355_GR.
KEGGcdf:CD2217.
NMPDRfig|1496.1.peg.2644.
PATRIC19442893. VBICloDif38397_2333.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0710.
HOGENOMHBG732926.
ProtClustDBCLSK2322871.

Family and domain databases

HAMAPMF_00214. AroD.
[Tree]
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK03785.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. AroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_CLOD6
AccessionPrimary (citable) accession number: Q186A6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: January 25, 2012
This is version 35 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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