ID   Q185T5_CLOD6            Unreviewed;       324 AA.
AC   Q185T5;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 2.
DT   27-MAR-2024, entry version 94.
DE   SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:CAJ69032.2};
GN   OrderedLocusNames=CD630_21480 {ECO:0000313|EMBL:CAJ69032.2};
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69032.2, ECO:0000313|Proteomes:UP000001978};
RN   [1] {ECO:0000313|EMBL:CAJ69032.2, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ69032.2,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
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DR   EMBL; AM180355; CAJ69032.2; -; Genomic_DNA.
DR   RefSeq; YP_001088661.2; NC_009089.1.
DR   AlphaFoldDB; Q185T5; -.
DR   SMR; Q185T5; -.
DR   STRING; 272563.CD630_21480; -.
DR   EnsemblBacteria; CAJ69032; CAJ69032; CD630_21480.
DR   KEGG; cdf:CD630_21480; -.
DR   KEGG; pdc:CDIF630_02378; -.
DR   PATRIC; fig|272563.120.peg.2267; -.
DR   eggNOG; COG0515; Bacteria.
DR   OrthoDB; 9786339at2; -.
DR   PhylomeDB; Q185T5; -.
DR   BioCyc; PDIF272563:G12WB-2304-MONOMER; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR045269; Atg1-like.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR24348:SF22; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR   PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:CAJ69032.2}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:CAJ69032.2};
KW   Transferase {ECO:0000313|EMBL:CAJ69032.2};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        305..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          8..271
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   324 AA;  37369 MW;  A3A130620BC5E313 CRC64;
     MNFIGNRYEV VNSDDVLEIN KIYKARDVFY RKNVLIKVIK HNNYICEDFV SNLIDESTAL
     DEINSPYILK IIDVGIHCTE ETTLYYVVSE DFNGIGLDEL ILGNYLHLEA IVNIMIQVLK
     ALEMIHRNHS YHGSLKSSSI IVDTEYNIKI CDFGITKANN GVNTRSYGNR RYLCPHQLCI
     NYTDKESDFF ATGLILFESI FKKLPFGESN SEEKMLQSID KGLDWNSIKA INGNTELINV
     IKRLLGRNNK YTRANDIIID LSKVMYEKAY IEVEDEKEEE QKQDKVIQVK KEYKSKMRKK
     LHKKLVVAGL AIVMISMIII SSII
//