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Q18581

- ACN1_CAEEL

UniProt

Q18581 - ACN1_CAEEL

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Protein

Inactive angiotensin-converting enzyme-related protein

Gene

acn-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for larval molting, male tail development, and formation of adult alae. Inactive as a metallopeptidase, due to a lack of active site residues.1 Publication

GO - Molecular functioni

  1. metallopeptidase activity Source: InterPro
  2. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive angiotensin-converting enzyme-related protein
Alternative name(s):
ACE-like non-metallopeptidase protein 1
Gene namesi
Name:acn-1
ORF Names:C42D8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC42D8.5a; CE30627; WBGene00000039; acn-1.
C42D8.5b; CE37212; WBGene00000039; acn-1.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 906887Inactive angiotensin-converting enzyme-related proteinPRO_0000028567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi159 – 1591N-linked (GlcNAc...)2 Publications
Glycosylationi653 – 6531N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ18581.
PRIDEiQ18581.

Expressioni

Tissue specificityi

Expressed in embryonic and larval hypodermis, in the vulva during organogenesis, and in the ray papillae of the male tail.1 Publication

Interactioni

Protein-protein interaction databases

IntActiQ18581. 1 interaction.
MINTiMINT-3385438.
STRINGi6239.C42D8.5a.

Structurei

3D structure databases

ProteinModelPortaliQ18581.
SMRiQ18581. Positions 177-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 9370Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG71044.
GeneTreeiENSGT00520000055576.
HOGENOMiHOG000020340.
InParanoidiQ18581.
KOiK01283.
OMAiRDGANEG.
PhylomeDBiQ18581.

Family and domain databases

InterProiIPR006149. EB_dom.
IPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01683. EB. 1 hit.
PF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q18581-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFHILLLLL VGACLPVFTQ EIKPKPELLP ADEAPKDPEA VFSEGEPFEL
60 70 80 90 100
TDALDTPKNG SVPVPEPEPK PEPEPEPEPK PEPEPSPTPE PEPAIKFDNI
110 120 130 140 150
ESEDYGDVAE TAASTQPDEL NTEVIEQLVD TFLNTGSIAS NKTNKGPVFA
160 170 180 190 200
NPVAQALVNS SNYWKTDNLQ APGSIKDEEK LRSWLAGYEA EAIKVLREVA
210 220 230 240 250
LSGWRYFNDA SPSLKLALDE AENVLTMFVR STSMQAKQFD MASVTDEKVM
260 270 280 290 300
RQLGYVSFEG MSALAPSRFA DYSQAQAALN RDSKDSTICD KDVPPPCALQ
310 320 330 340 350
KIDMDSIFRN EKDASRLQHL WVSYVTAIAK SKPSYNNIIT ISNEGAKLNG
360 370 380 390 400
FANGGAMWRS AFDMSSKVHK AEFDLNKQID KIYSTIQPFY QLLHAYMRRQ
410 420 430 440 450
LAGIYSNPVG LSKDGPIPAH LFGSLDGGDW SAHYEQTKPF EEESETPEAM
460 470 480 490 500
LSAFNTQNYT TKKMFVTAYR YFKSAGFPHL PKSYWTSSIF ARVWSKDMIC
510 520 530 540 550
HPAAALDMRA PNDFRVKACA QLGEPDFEQA HSLLVQTYYQ YLYKDQSLLF
560 570 580 590 600
REQASPVITD AIANAFAHLS TNPHYLYSQK LVPSEHLDIK DSVIINKLYK
610 620 630 640 650
ESLESFTKLP FTIAADNWRY ELFDGTVPKN KLNDRWWEIR NKYEGVRSPQ
660 670 680 690 700
PYNTSNLDAL IHNSVSQVHS PATRTLISYV LKFQILKALC PEGTILSEGC
710 720 730 740 750
ILSEDTTEKL RETMKLGSSI TWLKALEMIS GKGELDAQPL LEYYEPLINW
760 770 780 790 800
LRNTNEIDQV VVGWDGEGTP FTVEEIPKTR QPGDGGNGLP SEDRVAFPGG
810 820 830 840 850
ECVNGQECLL DSHCNGTICV CNDGLYTLEI GNTFNCVPGN PADSGFGDGK
860 870 880 890 900
GGLVIGLFNN EVTTPEPSAE PEPTAKTTTK MPPRVRAATS PFSLYLTVLL

IIYFAL
Length:906
Mass (Da):100,725
Last modified:October 1, 2002 - v2
Checksum:i50B3CD37EA62CBD3
GO
Isoform b (identifier: Q18581-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-197: SSNYWKTDNL...YEAEAIKVLR → LTLNHFSSTT...TEKELHSLCS
     198-773: Missing.

Note: No experimental confirmation available.

Show »
Length:332
Mass (Da):35,399
Checksum:iDF2528B20E9D6CF6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 19738SSNYW…IKVLR → LTLNHFSSTTSHSSTGSAIP MKSIRLLLDGTEKELHSLCS in isoform b. CuratedVSP_015490Add
BLAST
Alternative sequencei198 – 773576Missing in isoform b. CuratedVSP_015491Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080659 Genomic DNA. Translation: CCD65566.1.
FO080659 Genomic DNA. Translation: CCD65567.1.
PIRiT15792.
RefSeqiNP_001024453.1. NM_001029282.3. [Q18581-1]
NP_001024454.1. NM_001029283.3. [Q18581-2]
UniGeneiCel.38713.

Genome annotation databases

EnsemblMetazoaiC42D8.5a; C42D8.5a; WBGene00000039. [Q18581-1]
GeneIDi180780.
KEGGicel:CELE_C42D8.5.
UCSCiC42D8.5b.1. c. elegans. [Q18581-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080659 Genomic DNA. Translation: CCD65566.1 .
FO080659 Genomic DNA. Translation: CCD65567.1 .
PIRi T15792.
RefSeqi NP_001024453.1. NM_001029282.3. [Q18581-1 ]
NP_001024454.1. NM_001029283.3. [Q18581-2 ]
UniGenei Cel.38713.

3D structure databases

ProteinModelPortali Q18581.
SMRi Q18581. Positions 177-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q18581. 1 interaction.
MINTi MINT-3385438.
STRINGi 6239.C42D8.5a.

Proteomic databases

PaxDbi Q18581.
PRIDEi Q18581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C42D8.5a ; C42D8.5a ; WBGene00000039 . [Q18581-1 ]
GeneIDi 180780.
KEGGi cel:CELE_C42D8.5.
UCSCi C42D8.5b.1. c. elegans. [Q18581-1 ]

Organism-specific databases

CTDi 180780.
WormBasei C42D8.5a ; CE30627 ; WBGene00000039 ; acn-1.
C42D8.5b ; CE37212 ; WBGene00000039 ; acn-1.

Phylogenomic databases

eggNOGi NOG71044.
GeneTreei ENSGT00520000055576.
HOGENOMi HOG000020340.
InParanoidi Q18581.
KOi K01283.
OMAi RDGANEG.
PhylomeDBi Q18581.

Miscellaneous databases

NextBioi 910922.
PROi Q18581.

Family and domain databases

InterProi IPR006149. EB_dom.
IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01683. EB. 1 hit.
PF01401. Peptidase_M2. 1 hit.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site."
    Brooks D.R., Appleford P.J., Murray L., Isaac R.E.
    J. Biol. Chem. 278:52340-52346(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  3. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-159, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  4. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-159 AND ASN-653, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiACN1_CAEEL
AccessioniPrimary (citable) accession number: Q18581
Secondary accession number(s): Q65ZH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3