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Protein
Submitted name:

AcetylCholine Receptor

Gene

acr-9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
AcetylCholine ReceptorImported
Gene namesi
Name:acr-9Imported
ORF Names:C40C9.2Imported, CELE_C40C9.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC40C9.2; CE37330; WBGene00000048; acr-9.

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation
  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei243 – 262HelicalSequence analysisAdd BLAST20
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei304 – 329HelicalSequence analysisAdd BLAST26
Transmembranei509 – 528HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500418685025 – 534Sequence analysisAdd BLAST510

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ18556.

Expressioni

Gene expression databases

BgeeiWBGene00000048.

Interactioni

Protein-protein interaction databases

STRINGi6239.C40C9.2.

Structurei

3D structure databases

ProteinModelPortaliQ18556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 242Neur_chan_LBDInterPro annotationAdd BLAST215
Domaini249 – 525Neur_chan_membInterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
InParanoidiQ18556.
KOiK05312.
OMAiGNANAIW.
OrthoDBiEOG091G0R20.
PhylomeDBiQ18556.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPVLRLTA LHCVLFHLLT EVHSSADEYR LLADLRHNYD PYERPVANAS
60 70 80 90 100
EPLVVSVKIY LQQILDVDEK NQVITLVAWI EYQWTDYKLK WDPSEYGGIK
110 120 130 140 150
DIRIPGNANA IWKPDVLLYN SADENFDSTY PVNYVVSYTG DVLQVPPGIL
160 170 180 190 200
KLSCKIDITY FPFDDQICHL KFGSWTYSGN FIDLRINGPE GKNISDEGID
210 220 230 240 250
VQYYVQNGEW NLLAVPARHE TNIFDEQPYP SLFFYLIIQR RTLYYGLNLI
260 270 280 290 300
IPSFLISLMT VLGFTLPPDA GEKITLEITI LLSVCFFLSM VADMTPPTSE
310 320 330 340 350
AVPLIGAFFS CCMLVVSASV VFTVLVLNLH NRKPETHEMS PFLRELLLIW
360 370 380 390 400
LPWLLLMRRP GKTIFNCTHL KAEKAEEKAK QGSIKNGVGP GKPTDSVHPS
410 420 430 440 450
EGLSLMKNIK LGRQQTIDFE YEFHVQHNHL MPVAPSEMTP RVTYSKVMAE
460 470 480 490 500
SYVEDVVMTE LNKYMQKACL ELKNISSQTR AMRKKMEEDE RDEQAANDWK
510 520 530
FAAMVVDRCC LITFSVFIVV STCGIMFSSP HLIA
Length:534
Mass (Da):60,851
Last modified:November 23, 2004 - v3
Checksum:iAF0AF8EAFADCBB5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA94206.3.
PIRiT19862.
RefSeqiNP_510285.2. NM_077884.3.
UniGeneiCel.11548.

Genome annotation databases

EnsemblMetazoaiC40C9.2; C40C9.2; WBGene00000048.
GeneIDi191597.
KEGGicel:CELE_C40C9.2.
UCSCiC40C9.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA94206.3.
PIRiT19862.
RefSeqiNP_510285.2. NM_077884.3.
UniGeneiCel.11548.

3D structure databases

ProteinModelPortaliQ18556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C40C9.2.

Proteomic databases

PaxDbiQ18556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC40C9.2; C40C9.2; WBGene00000048.
GeneIDi191597.
KEGGicel:CELE_C40C9.2.
UCSCiC40C9.2. c. elegans.

Organism-specific databases

CTDi191597.
WormBaseiC40C9.2; CE37330; WBGene00000048; acr-9.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
InParanoidiQ18556.
KOiK05312.
OMAiGNANAIW.
OrthoDBiEOG091G0R20.
PhylomeDBiQ18556.

Enzyme and pathway databases

ReactomeiR-CEL-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Gene expression databases

BgeeiWBGene00000048.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ18556_CAEEL
AccessioniPrimary (citable) accession number: Q18556
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 23, 2004
Last modified: November 2, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.