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Protein

Proline iminopeptidase

Gene

pip

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Releases the N-terminal proline from various substrates.By similarity

Catalytic activityi

Release of N-terminal proline from a peptide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104NucleophileBy similarity1
Active sitei244By similarity1
Active sitei271Proton donorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3203-MONOMER.

Protein family/group databases

ESTHERipepd6-pip. Proline_iminopeptidase.
MEROPSiS33.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline iminopeptidaseImported (EC:3.4.11.5)
Short name:
PIPBy similarity
Alternative name(s):
Prolyl aminopeptidaseBy similarity
Short name:
PAPBy similarity
Gene namesi
Name:pipBy similarity
Synonyms:pepIImported
Ordered Locus Names:CD630_30410
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004063181 – 293Proline iminopeptidaseAdd BLAST293

Interactioni

Protein-protein interaction databases

STRINGi272563.CD3041.

Structurei

3D structure databases

ProteinModelPortaliQ184M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 277AB hydrolase-1Sequence analysisAdd BLAST250

Sequence similaritiesi

Belongs to the peptidase S33 family.Sequence analysis

Phylogenomic databases

eggNOGiENOG4107RCM. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000026004.
KOiK01259.
OMAiWGPNEYT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005945. Pro_imino_pep.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005539. Pept_S33_TRI_F1. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01250. pro_imino_pep_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q184M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITEGYMPF KGFKTYYRIV GENTEGKKPL VLLHGGPGST HNYFEVLDKI
60 70 80 90 100
AESGRQVIMY DQIGCGNSFV EGHPELFNAD TWIEELIELR KHLGLDEIHL
110 120 130 140 150
LGQSWGGMQA IWYAIEYKPK GIKSYILSST LSSAKLWEKE QKRRISYMSE
160 170 180 190 200
VDQKALLDAV NTGDYSSKEY NDALERFMEM YCAGEVTEDS PECLRRPKKS
210 220 230 240 250
GSEAYIVGWG QNEFSPTGTL SGYEFTDRLH EIKEPCLVTS GAIDLCSPYI
260 270 280 290
AKTMYDRIPN SKWELFEYSR HMPFVEENEK YIKVLTEWLN AND
Length:293
Mass (Da):33,663
Last modified:July 25, 2006 - v1
Checksum:i5B2A1900C5A9F2F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69934.1.
RefSeqiWP_003439900.1. NZ_CP010905.1.
YP_001089556.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69934; CAJ69934; CD630_30410.
GeneIDi4913725.
KEGGicdf:CD630_30410.
pdc:CDIF630_03325.
PATRICi19444603. VBICloDif38397_3185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69934.1.
RefSeqiWP_003439900.1. NZ_CP010905.1.
YP_001089556.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ184M8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD3041.

Protein family/group databases

ESTHERipepd6-pip. Proline_iminopeptidase.
MEROPSiS33.021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69934; CAJ69934; CD630_30410.
GeneIDi4913725.
KEGGicdf:CD630_30410.
pdc:CDIF630_03325.
PATRICi19444603. VBICloDif38397_3185.

Phylogenomic databases

eggNOGiENOG4107RCM. Bacteria.
COG0596. LUCA.
HOGENOMiHOG000026004.
KOiK01259.
OMAiWGPNEYT.

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3203-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR002410. Peptidase_S33.
IPR005945. Pro_imino_pep.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005539. Pept_S33_TRI_F1. 1 hit.
PRINTSiPR00793. PROAMNOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01250. pro_imino_pep_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIP_PEPD6
AccessioniPrimary (citable) accession number: Q184M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.