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Q184H7

- UPPP2_PEPD6

UniProt

Q184H7 - UPPP2_PEPD6

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Protein
Undecaprenyl-diphosphatase 2
Gene
uppP2, bacA2, upk2, CD630_29860
Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3221-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene namesi
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:CD630_29860
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Reviewed prediction
Add
BLAST
Transmembranei46 – 6621Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11421Helical; Reviewed prediction
Add
BLAST
Transmembranei119 – 13921Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Undecaprenyl-diphosphatase 2UniRule annotation
PRO_0000290699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2986.

Structurei

3D structure databases

ProteinModelPortaliQ184H7.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiWRKISSS.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q184H7-1 [UniParc]FASTAAdd to Basket

« Hide

MMSLDVIFIL KSVIIAIVEG LTEFIPVSST GHMILVGNLI DFKGQFAEMF    50
EVVIQLGAIL AVVVLYWKKI KDSVIEFFKF IFTGGKEGKI GFRFGMNVII 100
GCIPFAIIGV LFYDNIKSLF NLQSVIIGFI VGGILLLVVE TLFRKKNHST 150
DNIDKITPIQ ALKVGTLQVL SAWPGMSRSA STIMGGWIAG LNSPTAAEFS 200
FFLAVPAMVA SSGKDLFEFD YSIMTPTLWI ALVVGFIVAF IVSIIVMEKF 250
VNFLKKKPMR VFAVYRIIMG VVLAVLAFTN IISV 284
Length:284
Mass (Da):31,243
Last modified:July 25, 2006 - v1
Checksum:i2643F15CE60FEFFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ69880.1.
RefSeqiWP_011861775.1. NC_009089.1.
YP_001089504.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69880; CAJ69880; CD630_29860.
GeneIDi4915854.
KEGGicdf:CD630_29860.
PATRICi19444493. VBICloDif38397_3130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ69880.1 .
RefSeqi WP_011861775.1. NC_009089.1.
YP_001089504.1. NC_009089.1.

3D structure databases

ProteinModelPortali Q184H7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD2986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ69880 ; CAJ69880 ; CD630_29860 .
GeneIDi 4915854.
KEGGi cdf:CD630_29860.
PATRICi 19444493. VBICloDif38397_3130.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi WRKISSS.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CDIF272563:GJFE-3221-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiUPPP2_PEPD6
AccessioniPrimary (citable) accession number: Q184H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 25, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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