Reviewed, UniProtKB/Swiss-Prot Q184H7 (UPPP2_CLOD6)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2

Gene names

Name:	uppP2
Synonyms:	bacA2, upk2
Ordered Locus Names:	CD2986

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Undecaprenyl-diphosphatase 2 HAMAP MF_01006		PRO_0000290699
Regions
	Transmembrane	6 – 26	21	Potential
	Transmembrane	46 – 66	21	Potential
	Transmembrane	94 – 114	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	227 – 247	21	Potential
	Transmembrane	262 – 282	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q184H7-1 [UniParc]. Last modified July 25, 2006. Version 1. Checksum: 2643F15CE60FEFFB	FASTA	284	31,243
	10 20 30 40 50 60 MMSLDVIFIL KSVIIAIVEG LTEFIPVSST GHMILVGNLI DFKGQFAEMF EVVIQLGAIL 70 80 90 100 110 120 AVVVLYWKKI KDSVIEFFKF IFTGGKEGKI GFRFGMNVII GCIPFAIIGV LFYDNIKSLF 130 140 150 160 170 180 NLQSVIIGFI VGGILLLVVE TLFRKKNHST DNIDKITPIQ ALKVGTLQVL SAWPGMSRSA 190 200 210 220 230 240 STIMGGWIAG LNSPTAAEFS FFLAVPAMVA SSGKDLFEFD YSIMTPTLWI ALVVGFIVAF 250 260 270 280 IVSIIVMEKF VNFLKKKPMR VFAVYRIIMG VVLAVLAFTN IISV

References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome." Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T. , Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J. Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM180355 Genomic DNA. Translation: CAJ69880.1.
RefSeq	YP_001089504.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q184H7.
Genome annotation databases
GeneID	4915854.
GenomeReviews	Gene locus CD2986 in contig AM180355_GR.
KEGG	cdf:CD2986.
NMPDR	fig|1496.1.peg.606.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q184H7.
OMA	MRVFAVY.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_CLOD6

Accession

Primary (citable) accession number: Q184H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	July 25, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)