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Q184H7 (UPPP2_PEPD6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:CD630_29860
OrganismPeptoclostridium difficile (strain 630) (Clostridium difficile) [Complete proteome] [HAMAP]
Taxonomic identifier272563 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000290699

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane119 – 13921Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane262 – 28221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q184H7 [UniParc].

Last modified July 25, 2006. Version 1.
Checksum: 2643F15CE60FEFFB

FASTA28431,243
        10         20         30         40         50         60 
MMSLDVIFIL KSVIIAIVEG LTEFIPVSST GHMILVGNLI DFKGQFAEMF EVVIQLGAIL 

        70         80         90        100        110        120 
AVVVLYWKKI KDSVIEFFKF IFTGGKEGKI GFRFGMNVII GCIPFAIIGV LFYDNIKSLF 

       130        140        150        160        170        180 
NLQSVIIGFI VGGILLLVVE TLFRKKNHST DNIDKITPIQ ALKVGTLQVL SAWPGMSRSA 

       190        200        210        220        230        240 
STIMGGWIAG LNSPTAAEFS FFLAVPAMVA SSGKDLFEFD YSIMTPTLWI ALVVGFIVAF 

       250        260        270        280 
IVSIIVMEKF VNFLKKKPMR VFAVYRIIMG VVLAVLAFTN IISV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM180355 Genomic DNA. Translation: CAJ69880.1.
RefSeqYP_001089504.1. NC_009089.1.

3D structure databases

ProteinModelPortalQ184H7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272563.CD2986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ69880; CAJ69880; CD630_29860.
GeneID4915854.
KEGGcdf:CD630_29860.
PATRIC19444493. VBICloDif38397_3130.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAWRKISSS.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCDIF272563:GJFE-3221-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_PEPD6
AccessionPrimary (citable) accession number: Q184H7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families