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Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3221-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 2UniRule annotation
Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
Gene namesi
Name:uppP2UniRule annotation
Synonyms:bacA2, upk2
Ordered Locus Names:CD630_29860
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei46 – 6621HelicalUniRule annotationAdd
BLAST
Transmembranei94 – 11421HelicalUniRule annotationAdd
BLAST
Transmembranei119 – 13921HelicalUniRule annotationAdd
BLAST
Transmembranei183 – 20321HelicalUniRule annotationAdd
BLAST
Transmembranei227 – 24721HelicalUniRule annotationAdd
BLAST
Transmembranei262 – 28221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Undecaprenyl-diphosphatase 2PRO_0000290699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2986.

Structurei

3D structure databases

ProteinModelPortaliQ184H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiDSITFTQ.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q184H7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSLDVIFIL KSVIIAIVEG LTEFIPVSST GHMILVGNLI DFKGQFAEMF
60 70 80 90 100
EVVIQLGAIL AVVVLYWKKI KDSVIEFFKF IFTGGKEGKI GFRFGMNVII
110 120 130 140 150
GCIPFAIIGV LFYDNIKSLF NLQSVIIGFI VGGILLLVVE TLFRKKNHST
160 170 180 190 200
DNIDKITPIQ ALKVGTLQVL SAWPGMSRSA STIMGGWIAG LNSPTAAEFS
210 220 230 240 250
FFLAVPAMVA SSGKDLFEFD YSIMTPTLWI ALVVGFIVAF IVSIIVMEKF
260 270 280
VNFLKKKPMR VFAVYRIIMG VVLAVLAFTN IISV
Length:284
Mass (Da):31,243
Last modified:July 25, 2006 - v1
Checksum:i2643F15CE60FEFFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69880.1.
RefSeqiWP_011861775.1. NC_009089.1.
YP_001089504.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69880; CAJ69880; CD630_29860.
GeneIDi4915854.
KEGGicdf:CD630_29860.
PATRICi19444493. VBICloDif38397_3130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69880.1.
RefSeqiWP_011861775.1. NC_009089.1.
YP_001089504.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ184H7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69880; CAJ69880; CD630_29860.
GeneIDi4915854.
KEGGicdf:CD630_29860.
PATRICi19444493. VBICloDif38397_3130.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiDSITFTQ.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3221-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiUPPP2_PEPD6
AccessioniPrimary (citable) accession number: Q184H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 25, 2006
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.