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Q184E7

- VATA_PEPD6

UniProt

Q184E7 - VATA_PEPD6

Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.UniRule annotation

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi232 – 2398ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCDIF272563:GJFE-3189-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type ATP synthase alpha chainUniRule annotation (EC:3.6.3.14UniRule annotation)
    Alternative name(s):
    V-ATPase subunit AUniRule annotation
    Gene namesi
    Name:atpAUniRule annotation
    Ordered Locus Names:CD630_29560
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 592592V-type ATP synthase alpha chainPRO_0000322463Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272563.CD2956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ184E7.
    SMRiQ184E7. Positions 60-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1155.
    HOGENOMiHOG000161057.
    KOiK02117.
    OMAiENKITWN.
    OrthoDBiEOG6CP3V3.

    Family and domain databases

    Gene3Di1.10.1140.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00309. ATP_synth_A_arch.
    InterProiIPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q184E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTGTIVKVS GPLVVAEGMR DANMFDVVRV SDKHLIGEII EMHGDKASIQ    50
    VYEETSGLGP GEEVVSLGMP MSVELGPGLI STIYDGIQRP LEKMYDISGT 100
    NITKGVEVSS LDRTTKWEFK PKKSVGDKVV AGDIIGGVQE TAVVECKIMV 150
    PYGVKGTIKE IYSGEFTVED TVCVITDEKG NDIPVTMMQK WPVRKERPYR 200
    EKKTPDSLLV TGQRVIDTFF PITKGGVAAI PGPFGSGKTV TQHQLAKWAD 250
    ADIVVYIGCG ERGNEMTDVL LEFPELKDPR TGESLMQRTV LIANTSDMPV 300
    AAREASIYTG ITIAEYFRDM GYSVALMADS TSRWAEALRE MSGRLEEMPG 350
    EEGYPAYLGS RLAQFYERAG KVNCLGMDER EGTLTAIGAV SPPGGDTSEP 400
    VSQATLRIVK VFWGLDASLA YKRHFPAINW LTSYSLYQEK VDVWADKNVN 450
    DNFSAQRAQA MKLLQVESEL QEIVQLVGVD SLSDGDRLIL EVTRSIREDF 500
    LHQNSFHEVD TYTSLHKQYR MMGLILKFYK SAQDAIKQNV TINDIIKLSV 550
    LEKIGRAKYV EEGDIDAAYD SIEDEIDNEL ADLIKKRGAE EL 592
    Length:592
    Mass (Da):65,526
    Last modified:July 25, 2006 - v1
    Checksum:iEA32CAD099CE02F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ69848.1.
    RefSeqiYP_001089472.1. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ69848; CAJ69848; CD630_29560.
    GeneIDi4913755.
    KEGGicdf:CD630_29560.
    PATRICi19444433. VBICloDif38397_3100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ69848.1 .
    RefSeqi YP_001089472.1. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q184E7.
    SMRi Q184E7. Positions 60-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272563.CD2956.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ69848 ; CAJ69848 ; CD630_29560 .
    GeneIDi 4913755.
    KEGGi cdf:CD630_29560.
    PATRICi 19444433. VBICloDif38397_3100.

    Phylogenomic databases

    eggNOGi COG1155.
    HOGENOMi HOG000161057.
    KOi K02117.
    OMAi ENKITWN.
    OrthoDBi EOG6CP3V3.

    Enzyme and pathway databases

    BioCyci CDIF272563:GJFE-3189-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1140.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00309. ATP_synth_A_arch.
    InterProi IPR003593. AAA+_ATPase.
    IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630.

    Entry informationi

    Entry nameiVATA_PEPD6
    AccessioniPrimary (citable) accession number: Q184E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3