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Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 239ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-3120-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chainUniRule annotation (EC:3.6.3.14UniRule annotation)
Alternative name(s):
V-ATPase subunit AUniRule annotation
Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:CD630_29560
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003224631 – 592V-type ATP synthase alpha chainAdd BLAST592

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2956

Structurei

3D structure databases

ProteinModelPortaliQ184E7
SMRiQ184E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JIQ Bacteria
COG1155 LUCA
HOGENOMiHOG000161057
KOiK02117
OMAiQQLAKWS

Family and domain databases

Gene3Di1.10.1140.10, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_00309 ATP_synth_A_arch, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031686 ATP-synth_a_Xtn
IPR023366 ATP_synth_asu-like_sf
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034 ATPase_F1/V1_b/a_C
IPR027417 P-loop_NTPase
IPR022878 V-ATPase_asu
PANTHERiPTHR43607 PTHR43607, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PF16886 ATP-synt_ab_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q184E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTGTIVKVS GPLVVAEGMR DANMFDVVRV SDKHLIGEII EMHGDKASIQ
60 70 80 90 100
VYEETSGLGP GEEVVSLGMP MSVELGPGLI STIYDGIQRP LEKMYDISGT
110 120 130 140 150
NITKGVEVSS LDRTTKWEFK PKKSVGDKVV AGDIIGGVQE TAVVECKIMV
160 170 180 190 200
PYGVKGTIKE IYSGEFTVED TVCVITDEKG NDIPVTMMQK WPVRKERPYR
210 220 230 240 250
EKKTPDSLLV TGQRVIDTFF PITKGGVAAI PGPFGSGKTV TQHQLAKWAD
260 270 280 290 300
ADIVVYIGCG ERGNEMTDVL LEFPELKDPR TGESLMQRTV LIANTSDMPV
310 320 330 340 350
AAREASIYTG ITIAEYFRDM GYSVALMADS TSRWAEALRE MSGRLEEMPG
360 370 380 390 400
EEGYPAYLGS RLAQFYERAG KVNCLGMDER EGTLTAIGAV SPPGGDTSEP
410 420 430 440 450
VSQATLRIVK VFWGLDASLA YKRHFPAINW LTSYSLYQEK VDVWADKNVN
460 470 480 490 500
DNFSAQRAQA MKLLQVESEL QEIVQLVGVD SLSDGDRLIL EVTRSIREDF
510 520 530 540 550
LHQNSFHEVD TYTSLHKQYR MMGLILKFYK SAQDAIKQNV TINDIIKLSV
560 570 580 590
LEKIGRAKYV EEGDIDAAYD SIEDEIDNEL ADLIKKRGAE EL
Length:592
Mass (Da):65,526
Last modified:July 25, 2006 - v1
Checksum:iEA32CAD099CE02F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69848.1
RefSeqiWP_003426762.1, NZ_CP010905.2
YP_001089472.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ69848; CAJ69848; CD630_29560
GeneIDi31354569
4913755
KEGGicdf:CD630_29560
pdc:CDIF630_03239
PATRICifig|272563.120.peg.3122

Similar proteinsi

Entry informationi

Entry nameiVATA_PEPD6
AccessioniPrimary (citable) accession number: Q184E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health