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Q184E7

- VATA_PEPD6

UniProt

Q184E7 - VATA_PEPD6

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Protein
V-type ATP synthase alpha chain
Gene
atpA, CD630_29560
Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit By similarity.UniRule annotation

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi232 – 2398ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCDIF272563:GJFE-3189-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Gene namesi
Name:atpA
Ordered Locus Names:CD630_29560
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
ProteomesiUP000001978: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592V-type ATP synthase alpha chainUniRule annotation
PRO_0000322463Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2956.

Structurei

3D structure databases

ProteinModelPortaliQ184E7.
SMRiQ184E7. Positions 60-589.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1155.
HOGENOMiHOG000161057.
KOiK02117.
OMAiENKITWN.
OrthoDBiEOG6CP3V3.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00309. ATP_synth_A_arch.
InterProiIPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q184E7-1 [UniParc]FASTAAdd to Basket

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MKTGTIVKVS GPLVVAEGMR DANMFDVVRV SDKHLIGEII EMHGDKASIQ    50
VYEETSGLGP GEEVVSLGMP MSVELGPGLI STIYDGIQRP LEKMYDISGT 100
NITKGVEVSS LDRTTKWEFK PKKSVGDKVV AGDIIGGVQE TAVVECKIMV 150
PYGVKGTIKE IYSGEFTVED TVCVITDEKG NDIPVTMMQK WPVRKERPYR 200
EKKTPDSLLV TGQRVIDTFF PITKGGVAAI PGPFGSGKTV TQHQLAKWAD 250
ADIVVYIGCG ERGNEMTDVL LEFPELKDPR TGESLMQRTV LIANTSDMPV 300
AAREASIYTG ITIAEYFRDM GYSVALMADS TSRWAEALRE MSGRLEEMPG 350
EEGYPAYLGS RLAQFYERAG KVNCLGMDER EGTLTAIGAV SPPGGDTSEP 400
VSQATLRIVK VFWGLDASLA YKRHFPAINW LTSYSLYQEK VDVWADKNVN 450
DNFSAQRAQA MKLLQVESEL QEIVQLVGVD SLSDGDRLIL EVTRSIREDF 500
LHQNSFHEVD TYTSLHKQYR MMGLILKFYK SAQDAIKQNV TINDIIKLSV 550
LEKIGRAKYV EEGDIDAAYD SIEDEIDNEL ADLIKKRGAE EL 592
Length:592
Mass (Da):65,526
Last modified:July 25, 2006 - v1
Checksum:iEA32CAD099CE02F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ69848.1.
RefSeqiYP_001089472.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69848; CAJ69848; CD630_29560.
GeneIDi4913755.
KEGGicdf:CD630_29560.
PATRICi19444433. VBICloDif38397_3100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM180355 Genomic DNA. Translation: CAJ69848.1 .
RefSeqi YP_001089472.1. NC_009089.1.

3D structure databases

ProteinModelPortali Q184E7.
SMRi Q184E7. Positions 60-589.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272563.CD2956.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ69848 ; CAJ69848 ; CD630_29560 .
GeneIDi 4913755.
KEGGi cdf:CD630_29560.
PATRICi 19444433. VBICloDif38397_3100.

Phylogenomic databases

eggNOGi COG1155.
HOGENOMi HOG000161057.
KOi K02117.
OMAi ENKITWN.
OrthoDBi EOG6CP3V3.

Enzyme and pathway databases

BioCyci CDIF272563:GJFE-3189-MONOMER.

Family and domain databases

Gene3Di 1.10.1140.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00309. ATP_synth_A_arch.
InterProi IPR003593. AAA+_ATPase.
IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 630.

Entry informationi

Entry nameiVATA_PEPD6
AccessioniPrimary (citable) accession number: Q184E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 25, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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