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Protein

Acetyl-coenzyme A synthetase

Gene

acs-19

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
Name:acs-19Imported
ORF Names:C36A4.9Imported, CELE_C36A4.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC36A4.9a; CE03076; WBGene00007969; acs-19.

PTM / Processingi

Proteomic databases

EPDiQ18496.
PaxDbiQ18496.
PeptideAtlasiQ18496.

Expressioni

Gene expression databases

BgeeiWBGene00007969.
ExpressionAtlasiQ18496. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.C36A4.9a.1.

Structurei

3D structure databases

ProteinModelPortaliQ18496.
SMRiQ18496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 99ACAS_NInterPro annotationAdd BLAST60
Domaini106 – 553AMP-bindingInterPro annotationAdd BLAST448
Domaini562 – 640AMP-binding_CInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
InParanoidiQ18496.
KOiK01895.
OMAiNTHIEAT.
OrthoDBiEOG091G039C.
PhylomeDBiQ18496.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVRVKFNL ANDGEGLDED IFLPPAPLLA GAHCAGLQSY HDLYRSSIND
60 70 80 90 100
ADEFWRTVSS ELHFEQGTSK GLEWNFDSKA GNVFVKFMDG AKTNISYNCL
110 120 130 140 150
ERNIKRGYGN KIAYIFEGNE PTDTSTWTYN ELHAQVVQFS AVLRSHGVKR
160 170 180 190 200
GDVVALYLPM IPELAVAMLA CARIGAMHSV VFAGFSAESL AARVVDARCR
210 220 230 240 250
VLVTADGVFR GAKPIGLKSI ADAAAVLASQ EDVKVEAIIM VEHLKRVTKP
260 270 280 290 300
DGVELPKVDY TDITVIYDSE MLKCAGVDSP VEWMDSEDPL FILYTSGSTG
310 320 330 340 350
KPKGIQHTTA GYMTYAYATT KYTFDAQEDD VYWCTADCGW ITGHSYLLYG
360 370 380 390 400
PLMNGLKGIW YEGVPTYPTP SRMWDVTDKY GVTKLYTSPT AARALMALGN
410 420 430 440 450
QWLESSSRKT LKVIGTVGEP INPAAWMWLY KQVGLSNVSI VDTYWQTETG
460 470 480 490 500
GHMITCLPGA TPMKPGAAAM PFFGASPVLL DAEGRVIEGP GEGSLCFDRA
510 520 530 540 550
WPGMMRGIYG DEQRFVKTYL APFNGYYFTG DGARRDEDGY LWITGRVDDL
560 570 580 590 600
MNVSGHLLST AEIESALVAH EKVAEAAVVA APHDIKGSFP YAFVTLNVGE
610 620 630 640 650
RINEKLVAEL KKLVREKIGA LAVPDVIQEA PGLPKTRSGK VTRRILRKIA
660 670 680
EGSESGIGDT TTLVDESVIK QLISGRSARA
Length:680
Mass (Da):74,350
Last modified:November 1, 1996 - v1
Checksum:i8ABA18382CF4C1AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91274.1.
PIRiT19768.
RefSeqiNP_001021205.1. NM_001026034.3.
UniGeneiCel.17802.

Genome annotation databases

EnsemblMetazoaiC36A4.9a.1; C36A4.9a.1; WBGene00007969.
C36A4.9a.2; C36A4.9a.2; WBGene00007969.
GeneIDi175500.
KEGGicel:CELE_C36A4.9.
UCSCiC36A4.9a.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91274.1.
PIRiT19768.
RefSeqiNP_001021205.1. NM_001026034.3.
UniGeneiCel.17802.

3D structure databases

ProteinModelPortaliQ18496.
SMRiQ18496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C36A4.9a.1.

Proteomic databases

EPDiQ18496.
PaxDbiQ18496.
PeptideAtlasiQ18496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC36A4.9a.1; C36A4.9a.1; WBGene00007969.
C36A4.9a.2; C36A4.9a.2; WBGene00007969.
GeneIDi175500.
KEGGicel:CELE_C36A4.9.
UCSCiC36A4.9a.3. c. elegans.

Organism-specific databases

CTDi175500.
WormBaseiC36A4.9a; CE03076; WBGene00007969; acs-19.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
InParanoidiQ18496.
KOiK01895.
OMAiNTHIEAT.
OrthoDBiEOG091G039C.
PhylomeDBiQ18496.

Enzyme and pathway databases

ReactomeiR-CEL-71384. Ethanol oxidation.

Gene expression databases

BgeeiWBGene00007969.
ExpressionAtlasiQ18496. baseline and differential.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ18496_CAEEL
AccessioniPrimary (citable) accession number: Q18496
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.