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Protein

Acetyl-coenzyme A synthetase

Gene

acs-19

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
Name:acs-19Imported
ORF Names:C36A4.9Imported, CELE_C36A4.9Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC36A4.9a; CE03076; WBGene00007969; acs-19.

PTM / Processingi

Proteomic databases

EPDiQ18496.
PaxDbiQ18496.
PeptideAtlasiQ18496.

Expressioni

Gene expression databases

BgeeiWBGene00007969.
ExpressionAtlasiQ18496. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.C36A4.9a.1.

Structurei

3D structure databases

ProteinModelPortaliQ18496.
SMRiQ18496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 99ACAS_NInterPro annotationAdd BLAST60
Domaini106 – 553AMP-bindingInterPro annotationAdd BLAST448
Domaini562 – 640AMP-binding_CInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
GeneTreeiENSGT00760000119178.
HOGENOMiHOG000229981.
InParanoidiQ18496.
KOiK01895.
OMAiDHWWHDL.
OrthoDBiEOG091G039C.
PhylomeDBiQ18496.

Family and domain databases

CDDicd05966. ACS. 1 hit.
InterProiView protein in InterPro
IPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVRVKFNL ANDGEGLDED IFLPPAPLLA GAHCAGLQSY HDLYRSSIND
60 70 80 90 100
ADEFWRTVSS ELHFEQGTSK GLEWNFDSKA GNVFVKFMDG AKTNISYNCL
110 120 130 140 150
ERNIKRGYGN KIAYIFEGNE PTDTSTWTYN ELHAQVVQFS AVLRSHGVKR
160 170 180 190 200
GDVVALYLPM IPELAVAMLA CARIGAMHSV VFAGFSAESL AARVVDARCR
210 220 230 240 250
VLVTADGVFR GAKPIGLKSI ADAAAVLASQ EDVKVEAIIM VEHLKRVTKP
260 270 280 290 300
DGVELPKVDY TDITVIYDSE MLKCAGVDSP VEWMDSEDPL FILYTSGSTG
310 320 330 340 350
KPKGIQHTTA GYMTYAYATT KYTFDAQEDD VYWCTADCGW ITGHSYLLYG
360 370 380 390 400
PLMNGLKGIW YEGVPTYPTP SRMWDVTDKY GVTKLYTSPT AARALMALGN
410 420 430 440 450
QWLESSSRKT LKVIGTVGEP INPAAWMWLY KQVGLSNVSI VDTYWQTETG
460 470 480 490 500
GHMITCLPGA TPMKPGAAAM PFFGASPVLL DAEGRVIEGP GEGSLCFDRA
510 520 530 540 550
WPGMMRGIYG DEQRFVKTYL APFNGYYFTG DGARRDEDGY LWITGRVDDL
560 570 580 590 600
MNVSGHLLST AEIESALVAH EKVAEAAVVA APHDIKGSFP YAFVTLNVGE
610 620 630 640 650
RINEKLVAEL KKLVREKIGA LAVPDVIQEA PGLPKTRSGK VTRRILRKIA
660 670 680
EGSESGIGDT TTLVDESVIK QLISGRSARA
Length:680
Mass (Da):74,350
Last modified:November 1, 1996 - v1
Checksum:i8ABA18382CF4C1AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA91274.1.
PIRiT19768.
RefSeqiNP_001021205.1. NM_001026034.3.
UniGeneiCel.17802.

Genome annotation databases

EnsemblMetazoaiC36A4.9a.1; C36A4.9a.1; WBGene00007969.
C36A4.9a.2; C36A4.9a.2; WBGene00007969.
GeneIDi175500.
KEGGicel:CELE_C36A4.9.
UCSCiC36A4.9a.3. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ18496_CAEEL
AccessioniPrimary (citable) accession number: Q18496
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported