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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

cyn-12

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-CEL-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:cyn-12Imported
ORF Names:C34D4.12Imported, CELE_C34D4.12Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC34D4.12a; CE17506; WBGene00000888; cyn-12.

PTM / Processingi

Proteomic databases

EPDiQ18445.
PaxDbiQ18445.
PeptideAtlasiQ18445.

Expressioni

Gene expression databases

BgeeiWBGene00000888.
ExpressionAtlasiQ18445. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
T27F2.1Q228364EBI-2414398,EBI-322121

Protein-protein interaction databases

IntActiQ18445. 1 interactor.
STRINGi6239.C34D4.12.

Structurei

3D structure databases

ProteinModelPortaliQ18445.
SMRiQ18445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 162PPIase cyclophilin-typeInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0881. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
InParanoidiQ18445.
KOiK12733.
OMAiIELYWKH.
OrthoDBiEOG091G0NXS.
PhylomeDBiQ18445.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPINDQAP YVILDTTMGK IALELYWNHA PRTCQNFSQL AKRNYYNGTI
60 70 80 90 100
FHRIIADFMI QGGDPTGTGR GGASIYGDKF SDEIDERLKH TGAGILSMAN
110 120 130 140 150
AGPNTNGSQF FITLAPTQHL DGKHTIFGRV AAGMKVIANM GRVDTDNHDR
160
PKIEIRILKA YPSESSVLS
Length:169
Mass (Da):18,524
Last modified:November 1, 1996 - v1
Checksum:i835EBCC1C206F0A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD66606.1.
PIRiT29283.
RefSeqiNP_501118.1. NM_068717.3.
UniGeneiCel.13225.

Genome annotation databases

EnsemblMetazoaiC34D4.12a; C34D4.12a; WBGene00000888.
GeneIDi191627.
KEGGicel:CELE_C34D4.12.
UCSCiC34D4.12. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD66606.1.
PIRiT29283.
RefSeqiNP_501118.1. NM_068717.3.
UniGeneiCel.13225.

3D structure databases

ProteinModelPortaliQ18445.
SMRiQ18445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ18445. 1 interactor.
STRINGi6239.C34D4.12.

Proteomic databases

EPDiQ18445.
PaxDbiQ18445.
PeptideAtlasiQ18445.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34D4.12a; C34D4.12a; WBGene00000888.
GeneIDi191627.
KEGGicel:CELE_C34D4.12.
UCSCiC34D4.12. c. elegans.

Organism-specific databases

CTDi191627.
WormBaseiC34D4.12a; CE17506; WBGene00000888; cyn-12.

Phylogenomic databases

eggNOGiKOG0881. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
InParanoidiQ18445.
KOiK12733.
OMAiIELYWKH.
OrthoDBiEOG091G0NXS.
PhylomeDBiQ18445.

Enzyme and pathway databases

ReactomeiR-CEL-72163. mRNA Splicing - Major Pathway.

Gene expression databases

BgeeiWBGene00000888.
ExpressionAtlasiQ18445. baseline and differential.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ18445_CAEEL
AccessioniPrimary (citable) accession number: Q18445
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.