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Protein

Guanine nucleotide-binding protein alpha-17 subunit

Gene

odr-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:10192394). This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis (PubMed:9459442, PubMed:15342507). Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione (PubMed:12694294). Displays a redundant function with gpa-3 in chemotactic responses (PubMed:12694294). Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid (PubMed:12694294). Involved in osmotic avoidance and mechanosensory responses (PubMed:12694294). Involved in specifying fan-like morphology of cilia of head sensory neurons AWC (PubMed:9459442). Plays a role in the detection of preferred food sources by mediating the recognition of food oders in olfactory sensory neurons (PubMed:25009271).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumBy similarity1
Metal bindingi183MagnesiumBy similarity1
Binding sitei328GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi177 – 183GTPBy similarity7
Nucleotide bindingi202 – 206GTPBy similarity5
Nucleotide bindingi271 – 274GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
  • chemotaxis Source: UniProtKB-KW
  • cilium assembly Source: UniProtKB
  • hyperosmotic response Source: WormBase
  • olfactory behavior Source: UniProtKB
  • response to odorant Source: UniProtKB
  • sensory perception of smell Source: UniProtKB-KW

Keywordsi

Molecular functionTransducer
Biological processChemotaxis, Olfaction, Sensory transduction
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-17 subunit
Alternative name(s):
Odorant response abnormal protein 3
Gene namesi
Name:odr-3
ORF Names:C34D1.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC34D1.3; CE08571; WBGene00003850; odr-3.

Subcellular locationi

  • Cell projectioncilium 1 Publication
  • Cell projectiondendrite 1 Publication

  • Note: In amphid neurons also weakly expressed in cell body. In phasmid neurons found only in cilia.

GO - Cellular componenti

  • dendrite Source: UniProtKB-SubCell
  • heterotrimeric G-protein complex Source: GO_Central
  • neuronal cell body Source: WormBase
  • non-motile cilium Source: WormBase

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Defective in chemotactic responses to attractants and repellents and in osmotic and mechanosensory avoidance.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi47S → C: Loss of chemotactic responses. 1 Publication1
Mutagenesisi206Q → L: Loss of chemotactic and osmotic avoidance responses. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002036592 – 356Guanine nucleotide-binding protein alpha-17 subunitAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Lipidationi4S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiQ18434.
PaxDbiQ18434.
PeptideAtlasiQ18434.

Expressioni

Tissue specificityi

Expressed in sensory neurons in the head and tail. Expressed in amphid AWC neurons, to a lesser extent in AWB and weakly in AWA, ASH and ADF neurons (head sensory neurons). Expressed in phasmid PHA and PHB neurons (tail sensory neurons).2 Publications

Gene expression databases

BgeeiWBGene00003850.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (By similarity).By similarity

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: GO_Central
  • olfactory receptor binding Source: WormBase

Protein-protein interaction databases

STRINGi6239.C34D1.3.

Structurei

3D structure databases

ProteinModelPortaliQ18434.
SMRiQ18434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
InParanoidiQ18434.
KOiK04640.
OMAiMQILHSN.
OrthoDBiEOG091G0VUT.
PhylomeDBiQ18434.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
InterProiView protein in InterPro
IPR001408. Gprotein_alpha_I.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiView protein in Pfam
PF00503. G-alpha. 1 hit.
PRINTSiPR00318. GPROTEINA.
PR00441. GPROTEINAI.
SMARTiView protein in SMART
SM00275. G_alpha. 1 hit.
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCQSNENS EGNARNKEIE KQLNADKRAG SSIVKLLLLG AGECGKSTVL
60 70 80 90 100
KQMQILHSNG FTEEEVNEKR AIVYNNTVSA MCTILRAMDG VLHLPLENGQ
110 120 130 140 150
KEAEKAIVMK VQENGEEGEA LTEEVSKAIQ SLWADPGVKK AFEMRSEYQL
160 170 180 190 200
PDSAKYFLDN CQRISEPGYR PNDQDILYSR VATTGVVEVK FKIKELDFRV
210 220 230 240 250
FDVGGQRSER RKWIHCFDNV ESIIFITAIS EYDQVLFEDE TTNRMIESMQ
260 270 280 290 300
LFNSICNSTW FLSTAMILFM NKKDLFMEKI QRVNITTAFP DYEGGQNYEE
310 320 330 340 350
AVSFIKQKFA ELNLNPDKKT IYMHETCATD TNQVQLVISS VIDTIIQKNL

QKAGMM
Length:356
Mass (Da):40,434
Last modified:November 1, 1996 - v1
Checksum:iCB9F36F5F4FB95D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008142 mRNA. Translation: AAG32095.1.
FJ455729 Genomic DNA. Translation: ACQ43989.1.
FJ455730 Genomic DNA. Translation: ACQ43990.1.
FJ455731 Genomic DNA. Translation: ACQ43991.1.
Z78060 Genomic DNA. Translation: CAB01489.1.
AY146558 Genomic DNA. Translation: AAN78230.1.
AY146559 Genomic DNA. Translation: AAN78231.1.
AY146560 Genomic DNA. Translation: AAN78232.1.
AY146561 Genomic DNA. Translation: AAN78233.1.
AY146562 Genomic DNA. Translation: AAN78234.1.
AY146563 Genomic DNA. Translation: AAN78235.1.
AY146564 Genomic DNA. Translation: AAN78236.1.
AY146565 Genomic DNA. Translation: AAN78237.1.
AY146566 Genomic DNA. Translation: AAN78238.1.
PIRiT19715.
RefSeqiNP_506290.1. NM_073889.1.
UniGeneiCel.2932.

Genome annotation databases

EnsemblMetazoaiC34D1.3; C34D1.3; WBGene00003850.
GeneIDi179806.
KEGGicel:CELE_C34D1.3.
UCSCiC34D1.3. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiGPA17_CAEEL
AccessioniPrimary (citable) accession number: Q18434
Secondary accession number(s): C3U544
, Q867E1, Q867N8, Q868B7, Q86FY4, Q86FY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families