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Protein

GrpE protein homolog, mitochondrial

Gene

C34C12.8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
Gene namesi
ORF Names:C34C12.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC34C12.8 ; CE03057 ; WBGene00007927

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000013047? – 237GrpE protein homolog, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ18421
PaxDbiQ18421
PeptideAtlasiQ18421
PRIDEiQ18421

2D gel databases

World-2DPAGE0020:Q18421

Expressioni

Gene expression databases

BgeeiWBGene00007927

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14/dnj-21.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi40691, 4 interactors
DIPiDIP-26028N
STRINGi6239.C34C12.8.1

Structurei

3D structure databases

ProteinModelPortaliQ18421
SMRiQ18421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003 Eukaryota
COG0576 LUCA
GeneTreeiENSGT00390000005589
HOGENOMiHOG000252083
InParanoidiQ18421
KOiK03687
OMAiVPAEGMQ
OrthoDBiEOG091G0O5D
PhylomeDBiQ18421

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGVSFVG QAVQQTLKTQ KNLRIQRFSA TASQSSEEVN YEIRKDGKRL
60 70 80 90 100
RGADYEEIVL TSIAGEDKTQ IPKGAFDVLL KEYDDLQAES LDFKDKYQRS
110 120 130 140 150
LAETENVRRR GIKQTDDAKV FAIQSFCKDL LEVSDILDIA VKSVKPEDLE
160 170 180 190 200
SGGKALKDLF EGVSMTRTVM AKTFAKHGLV TVDPTNEKFD PNLHEAVFQI
210 220 230
PSANAKQPVG HIEVCTKIGY SLKERPIRPA QVGVVSK
Length:237
Mass (Da):26,448
Last modified:November 1, 1996 - v1
Checksum:i24C160D76ADD2A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46996 Genomic DNA Translation: CAA87101.1
PIRiT19702
RefSeqiNP_497713.1, NM_065312.4
UniGeneiCel.10759

Genome annotation databases

EnsemblMetazoaiC34C12.8; C34C12.8; WBGene00007927
GeneIDi175449
KEGGicel:CELE_C34C12.8
UCSCiC34C12.8 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGRPE_CAEEL
AccessioniPrimary (citable) accession number: Q18421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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