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Protein

GrpE protein homolog, mitochondrial

Gene

C34C12.8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
Gene namesi
ORF Names:C34C12.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC34C12.8; CE03057; WBGene00007927.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 237GrpE protein homolog, mitochondrialPRO_0000013047
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ18421.
PaxDbiQ18421.

2D gel databases

World-2DPAGE0020:Q18421.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14/dnj-21.By similarity

Protein-protein interaction databases

BioGridi40691. 4 interactions.
DIPiDIP-26028N.
MINTiMINT-1121823.
STRINGi6239.C34C12.8.1.

Structurei

3D structure databases

ProteinModelPortaliQ18421.
SMRiQ18421. Positions 85-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
InParanoidiQ18421.
KOiK03687.
OMAiFQIPSAN.
PhylomeDBiQ18421.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGVSFVG QAVQQTLKTQ KNLRIQRFSA TASQSSEEVN YEIRKDGKRL
60 70 80 90 100
RGADYEEIVL TSIAGEDKTQ IPKGAFDVLL KEYDDLQAES LDFKDKYQRS
110 120 130 140 150
LAETENVRRR GIKQTDDAKV FAIQSFCKDL LEVSDILDIA VKSVKPEDLE
160 170 180 190 200
SGGKALKDLF EGVSMTRTVM AKTFAKHGLV TVDPTNEKFD PNLHEAVFQI
210 220 230
PSANAKQPVG HIEVCTKIGY SLKERPIRPA QVGVVSK
Length:237
Mass (Da):26,448
Last modified:November 1, 1996 - v1
Checksum:i24C160D76ADD2A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46996 Genomic DNA. Translation: CAA87101.1.
PIRiT19702.
RefSeqiNP_497713.1. NM_065312.4.
UniGeneiCel.10759.

Genome annotation databases

EnsemblMetazoaiC34C12.8; C34C12.8; WBGene00007927.
GeneIDi175449.
KEGGicel:CELE_C34C12.8.
UCSCiC34C12.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46996 Genomic DNA. Translation: CAA87101.1.
PIRiT19702.
RefSeqiNP_497713.1. NM_065312.4.
UniGeneiCel.10759.

3D structure databases

ProteinModelPortaliQ18421.
SMRiQ18421. Positions 85-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40691. 4 interactions.
DIPiDIP-26028N.
MINTiMINT-1121823.
STRINGi6239.C34C12.8.1.

2D gel databases

World-2DPAGE0020:Q18421.

Proteomic databases

EPDiQ18421.
PaxDbiQ18421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34C12.8; C34C12.8; WBGene00007927.
GeneIDi175449.
KEGGicel:CELE_C34C12.8.
UCSCiC34C12.8. c. elegans.

Organism-specific databases

CTDi175449.
WormBaseiC34C12.8; CE03057; WBGene00007927.

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
InParanoidiQ18421.
KOiK03687.
OMAiFQIPSAN.
PhylomeDBiQ18421.

Miscellaneous databases

PROiQ18421.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGRPE_CAEEL
AccessioniPrimary (citable) accession number: Q18421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.