ID   NTP1_CAEEL              Reviewed;         485 AA.
AC   Q18411;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   05-MAY-2009, entry version 48.
DE   RecName: Full=Nucleoside-triphosphatase ntp-1;
DE            EC=3.6.1.15;
GN   Name=ntp-1; ORFNames=C33H5.14;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   CATALYTIC ACTIVITY, AND SUBCELLULAR LOCATION.
RX   PubMed=15102851; DOI=10.1074/jbc.M402624200;
RA   Uccelletti D., O'Callaghan C., Berninsone P., Zemtseva I., Abeijon C.,
RA   Hirschberg C.B.;
RT   "ire-1-dependent transcriptional up-regulation of a lumenal uridine
RT   diphosphatase from Caenorhabditis elegans.";
RL   J. Biol. Chem. 279:27390-27398(2004).
CC   -!- FUNCTION: Seems to be able to hydrolyze CTP, ATP and UTP.
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass
CC       membrane protein (Potential).
CC   -!- MISCELLANEOUS: In contrast to uda-1, expression is not induced by
CC       stress.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
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DR   EMBL; U41007; AAA82272.1; -; Genomic_DNA.
DR   PIR; T34147; T34147.
DR   RefSeq; NP_501289.1; -.
DR   UniGene; Cel.17788; -.
DR   Ensembl; C33H5.14; Caenorhabditis elegans.
DR   GeneID; 177567; -.
DR   KEGG; cel:C33H5.14; -.
DR   WormBase; WBGene00016380; ntp-1.
DR   WormPep; C33H5.14; CE04157.
DR   OMA; Q18411; ICDAGSS.
DR   BRENDA; 3.6.1.15; 672.
DR   NextBio; 897400; -.
DR   ArrayExpress; Q18411; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:EC.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; GDA1_CD39_NTPase; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Golgi apparatus; Hydrolase; Membrane;
KW   Transmembrane.
FT   CHAIN         1    485       Nucleoside-triphosphatase ntp-1.
FT                                /FTId=PRO_0000209924.
FT   TRANSMEM    439    459       Potential.
SQ   SEQUENCE   485 AA;  54309 MW;  DE64D1ADC20F581E CRC64;
     MSGGSSERVQ RSVRSVVETK NNIKYGVICD AGSSGTRLFV YTLKPLSGGL TNIDTLIHES
     EPVVKKVTPG LSSFGDKPEQ VVEYLTPLLR FAEEHIPYEQ LGETDLLIFA TAGMRLLPEA
     QKDAIIKNLQ NGLKSVTALR VSDSNIRIID GAWEGIYSWI AVNYILGRFD KENDSKVGMI
     DMGGASVQIA FEIANEKESY NGGNVYEINL GSIETNEDYK YKIYSTTFLG YGANEGLKKY
     ENSLVKSGNS NDSCSPRGLN RLIGEFTVNG TGEWDVCLAQ VSSLIGDKAQ PSCPNPTCFL
     RNVIAPSVNL STVQLYGFSE YWYTTSNFGS GGEYHYQKFT DEVRKYCQKD WNDIQDGFKR
     NEFPNADIER LGTNCFKAAW VTSVLHDGFN VDKTKHLFQS VLKIAGEEMQ WALGAMLYHS
     KDLKFNLLEQ LEVAQSTQQI SNFFSFFVIL IIVLAVALYR QLQSESTYKK YNFLRTDSKP
     DFLNV
//