Reviewed, UniProtKB/Swiss-Prot Q18411 (NTP1_CAEEL)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase ntp-1
    EC=3.6.1.15

Gene names

Name:	ntp-1
ORF Names:	C33H5.14

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to be able to hydrolyze CTP, ATP and UTP.
Catalytic activity	NTP + H2O = NDP + phosphate. Ref.2
Subcellular location	Golgi apparatus membrane; Single-pass membrane protein Potential.
Miscellaneous	In contrast to uda-1, expression is not induced by stress.
Sequence similarities	Belongs to the GDA1/CD39 NTPase family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Nucleoside-triphosphatase ntp-1		PRO_0000209924
Regions
	Transmembrane	439 – 459	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q18411-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: DE64D1ADC20F581E	FASTA	485	54,309
	10 20 30 40 50 60 MSGGSSERVQ RSVRSVVETK NNIKYGVICD AGSSGTRLFV YTLKPLSGGL TNIDTLIHES 70 80 90 100 110 120 EPVVKKVTPG LSSFGDKPEQ VVEYLTPLLR FAEEHIPYEQ LGETDLLIFA TAGMRLLPEA 130 140 150 160 170 180 QKDAIIKNLQ NGLKSVTALR VSDSNIRIID GAWEGIYSWI AVNYILGRFD KENDSKVGMI 190 200 210 220 230 240 DMGGASVQIA FEIANEKESY NGGNVYEINL GSIETNEDYK YKIYSTTFLG YGANEGLKKY 250 260 270 280 290 300 ENSLVKSGNS NDSCSPRGLN RLIGEFTVNG TGEWDVCLAQ VSSLIGDKAQ PSCPNPTCFL 310 320 330 340 350 360 RNVIAPSVNL STVQLYGFSE YWYTTSNFGS GGEYHYQKFT DEVRKYCQKD WNDIQDGFKR 370 380 390 400 410 420 NEFPNADIER LGTNCFKAAW VTSVLHDGFN VDKTKHLFQS VLKIAGEEMQ WALGAMLYHS 430 440 450 460 470 480 KDLKFNLLEQ LEVAQSTQQI SNFFSFFVIL IIVLAVALYR QLQSESTYKK YNFLRTDSKP DFLNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." Uccelletti D., O'Callaghan C., Berninsone P., Zemtseva I., Abeijon C., Hirschberg C.B. J. Biol. Chem. 279:27390-27398(2004) [PubMed: 15102851] [Abstract] Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U41007 Genomic DNA. Translation: AAA82272.1.
PIR	T34147.
RefSeq	NP_501289.1.
UniGene	Cel.17788
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	C33H5.14. Caenorhabditis elegans. [Contig view]
GeneID	177567.
KEGG	cel:C33H5.14.
Organism-specific databases
WormBase	WBGene00016380. ntp-1.
WormPep	C33H5.14. CE04157. [WorfDB]
Phylogenomic databases
OMA	Q18411. ICDAGSS.
Enzyme and pathway databases
BRENDA	3.6.1.15. 672.
Gene expression databases
ArrayExpress	Q18411.
Family and domain databases
InterPro	IPR000407. GDA1_CD39_NTPase. [Graphical view]
PANTHER	PTHR11782. GDA1_CD39_NTPase. 1 hit.
Pfam	PF01150. GDA1_CD39. 1 hit. [Graphical view]
PROSITE	PS01238. GDA1_CD39_NTPASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	897400.

Entry information

Entry name

NTP1_CAEEL

Accession

Primary (citable) accession number: Q18411

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 5, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project