ID   Q183I3_CLOD6            Unreviewed;       554 AA.
AC   Q183I3;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Ubiquinone biosynthesis protein {ECO:0000313|EMBL:CAJ69634.1};
GN   OrderedLocusNames=CD630_27470 {ECO:0000313|EMBL:CAJ69634.1};
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69634.1, ECO:0000313|Proteomes:UP000001978};
RN   [1] {ECO:0000313|EMBL:CAJ69634.1, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ69634.1,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC       kinase family. {ECO:0000256|ARBA:ARBA00009670}.
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DR   EMBL; AM180355; CAJ69634.1; -; Genomic_DNA.
DR   RefSeq; WP_009891005.1; NZ_JAUPES010000010.1.
DR   RefSeq; YP_001089259.1; NC_009089.1.
DR   AlphaFoldDB; Q183I3; -.
DR   STRING; 272563.CD630_27470; -.
DR   EnsemblBacteria; CAJ69634; CAJ69634; CD630_27470.
DR   KEGG; cdf:CD630_27470; -.
DR   KEGG; pdc:CDIF630_03010; -.
DR   PATRIC; fig|272563.120.peg.2894; -.
DR   eggNOG; COG0661; Bacteria.
DR   OrthoDB; 9795390at2; -.
DR   PhylomeDB; Q183I3; -.
DR   BioCyc; PDIF272563:G12WB-2905-MONOMER; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd05121; ABC1_ADCK3-like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR004147; ABC1_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR10566; CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED; 1.
DR   PANTHER; PTHR10566:SF129; PROTEIN KINASE UBIB-RELATED; 1.
DR   Pfam; PF03109; ABC1; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubiquinone {ECO:0000313|EMBL:CAJ69634.1}.
FT   TRANSMEM        496..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        522..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          123..426
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   554 AA;  63922 MW;  63A9F83E27E511D4 CRC64;
     MRISYRNLKR YREIGYVLIK YGFSFIVERL NIEGIAYKIP LFDPPEEIKN MTTGERMKRV
     LEELGPTYIK IGQILSTRKD LLDQDIIDEI SKLRDDVEKF DSNIAIDIFK EEVGLSIEEI
     FLEFKEEPIA AASIGQVYEG VLKTGEEVIV KIQRPNIEKI IKSDLEILRT IANTLKDLKK
     DFNLDLVQMI EEFQTQLMRE LDYTFEAINA TKFSRIFKNS DEVYIPKVYS EYNTKKILVM
     EKVNGTKLSD VEKIRRLGYN TKTIVEIGVR SFFTQVLSHG FFHADPHPGN IFVVAKNKIA
     YIDFGMIGII DNKTLNQLNE IALAGVEKNV DKIIYLLIEM DALNGEADIK GLRQDLLYLI
     HYYYDISIEK INVTDILNEL FRFFRQYKIV MPAQFVTLAK TVITLEGTSR TLNTDFSFGS
     MGKEFMKHHY KSKFNPKNVV LSSRQNVEEI LLDIKTIPKQ LKAILKNIER NNIKMQIEDV
     KMTRLENCII ELTSQISLSL VLASIIVGSS LIIASPNIEN NIWIKFTAIA GFFISFIIGL
     CLVIRSIRSK YKKD
//