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Protein

D-aminoacyl-tRNA deacylase

Gene

dtd

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.UniRule annotation

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2901-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylaseUniRule annotation (EC:3.1.1.96UniRule annotation)
Alternative name(s):
D-tyrosyl-tRNA(Tyr) deacylase
Gene namesi
Name:dtdUniRule annotation
Ordered Locus Names:CD630_27430
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002592711 – 149D-aminoacyl-tRNA deacylaseAdd BLAST149

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2743.

Structurei

3D structure databases

ProteinModelPortaliQ183H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DTD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YYA. Bacteria.
COG1490. LUCA.
HOGENOMiHOG000113981.
KOiK07560.
OMAiDGPVTIW.

Family and domain databases

CDDicd00563. Dtyr_deacylase. 1 hit.
Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.

Sequencei

Sequence statusi: Complete.

Q183H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVVQRVSS SKVTVDENTI GQINKGLLVL LGVTHDDKSS DVDYMIDKIL
60 70 80 90 100
NLRIFEDEND KMNLSLMDIG GELLVVSQFT LYGDCRKGRR PGFSNAARPE
110 120 130 140
LANNLYEEFV KKAKDKGVTV GTGQFAAHMM VELTNDGPVT ILLDSSKSF
Length:149
Mass (Da):16,457
Last modified:July 25, 2006 - v1
Checksum:i6733FCFCEBAF452D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69630.1.
RefSeqiWP_003426448.1. NZ_CP010905.1.
YP_001089255.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69630; CAJ69630; CD630_27430.
GeneIDi4915428.
KEGGicdf:CD630_27430.
pdc:CDIF630_03006.
PATRICi19443973. VBICloDif38397_2870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69630.1.
RefSeqiWP_003426448.1. NZ_CP010905.1.
YP_001089255.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ183H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69630; CAJ69630; CD630_27430.
GeneIDi4915428.
KEGGicdf:CD630_27430.
pdc:CDIF630_03006.
PATRICi19443973. VBICloDif38397_2870.

Phylogenomic databases

eggNOGiENOG4108YYA. Bacteria.
COG1490. LUCA.
HOGENOMiHOG000113981.
KOiK07560.
OMAiDGPVTIW.

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2901-MONOMER.

Family and domain databases

CDDicd00563. Dtyr_deacylase. 1 hit.
Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDTD_PEPD6
AccessioniPrimary (citable) accession number: Q183H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.