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Protein

Receptor-type guanylate cyclase gcy-11

Gene

gcy-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).By similarity

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1001 – 10011Magnesium 1PROSITE-ProRule annotation
Metal bindingi1001 – 10011Magnesium 2PROSITE-ProRule annotation
Metal bindingi1002 – 10021Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi1045 – 10451Magnesium 1PROSITE-ProRule annotation
Metal bindingi1045 – 10451Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase, Receptor

Keywords - Biological processi

cGMP biosynthesis

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type guanylate cyclase gcy-11Curated (EC:4.6.1.2By similarity)
Gene namesi
Name:gcy-11Imported
ORF Names:C30G4.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC30G4.3; CE48005; WBGene00001537; gcy-11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 322304ExtracellularSequence analysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence analysisAdd
BLAST
Topological domaini344 – 1205862CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 12051187Receptor-type guanylate cyclase gcy-11Sequence analysisPRO_0000433280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi82 – 821N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)PROSITE-ProRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ18331.
PaxDbiQ18331.
PRIDEiQ18331.

Expressioni

Tissue specificityi

Expressed in pharyngeal muscle.1 Publication

Gene expression databases

BgeeiWBGene00001537.

Interactioni

Protein-protein interaction databases

STRINGi6239.C30G4.3.

Structurei

3D structure databases

ProteinModelPortaliQ18331.
SMRiQ18331. Positions 673-949, 987-1157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini599 – 925327Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini996 – 1126131Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili933 – 97341Sequence analysisAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000118959.
HOGENOMiHOG000020750.
InParanoidiQ18331.
OMAiHENLNRF.
OrthoDBiEOG091G01DC.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q18331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCREIFLLW ILVPIASSSD HITFFGRYAC NVDFKTDYCT PDTYVGRAFY
60 70 80 90 100
YGLEDGGGIT TNGTFVNSDI TVEFFDPTVQ GNFSIGRQDG NYMSMEMKKK
110 120 130 140 150
KGRRRTRHVS FEEEEEETDS HLLSPPRYLQ RLFEIYDKGW KQKSKNECSH
160 170 180 190 200
VFKLWSIYGS GRKNVSTKNV MLSMLDIMLA DTKKNDGLLG VVGVENDCKE
210 220 230 240 250
IAALAQAYDA SSLLVNCEDQ VGESQMPSST ALQMSSTQGG KYRAFAKLAK
260 270 280 290 300
SVGWNNLAVI NFVEDGPADI SYHDQLLDAL SAESISLDFV KKGGFSSTIT
310 320 330 340 350
SAMFTGLESV IDVILETYMK TRIYVIVLDL PVSGTFFMNA MSTMGLLETG
360 370 380 390 400
KYFVVMMSSI ESDAANYFGF NVNRDFSDEW TSFQKRVDGD ASKTFCPPMC
410 420 430 440 450
NTKAKGIANN DPWSDDAYWY SESPSIVDAY DLGRLLSETV KVHGASLLRD
460 470 480 490 500
PESLVQTMSG RGVTSLLGYV TKFNTNGVSQ REYILWAPQQ ASSSNGPIPL
510 520 530 540 550
PEWATLAARM LPDGKGNYSI IWKNLTQLGI FNGELPQSKP ECGFNNELCP
560 570 580 590 600
AGIPESEPSS FFDFSKNLYL KKRVVLKWIA YERRLESSYF LVHRKHVQLV
610 620 630 640 650
DMTKFGSSRG GSMIQSAMSM RSQYEDSGPV GGATMNFYTN GIRKAAIRRN
660 670 680 690 700
QMQRSDKGPA ANRDEWLEIV DWHLAKYENT LVTVRKINKT QLKLTREMKQ
710 720 730 740 750
EIDLLMNETH ENLNRFFGLI NESDLIFTIH SYGPRKSLMD LLRNDDLRLD
760 770 780 790 800
RMFKVSFVED VVKGLQFLHE GSKIGYHGNL KSSNCIVDAY WRIKLSNYGM
810 820 830 840 850
EQIRVEEPES KPDDLLWFAP EIIRRYAVKH DLSKLELAKA DIYSLAIVLY
860 870 880 890 900
EIYGRQGPFG DDLLDSDEII EQLKFPDGGA LTRPDIHLIT KAPYPLASVV
910 920 930 940 950
EKCWVEDPAS RPSIKKVREL LKPLSKGLKG NIADNIMNLL DRYRNNLEDV
960 970 980 990 1000
IKERTEQLED ERKRNESLLL QLLPKSVANS LKNGQPVDAE FYDSVSIYFS
1010 1020 1030 1040 1050
DIVGFTALSS KSTPLQVVNM LNNLYTNFDT IIDKFDCYKV ETIGDAYMFV
1060 1070 1080 1090 1100
SGLPEVNSYL HAGEVASASL ELLDSIKTFT VSHCPDEKLR LRIGNHTGPV
1110 1120 1130 1140 1150
VTGVVGIRMP RYCLFGDTVI IANMMESSGE PMRIQISSDA YELILKCGGY
1160 1170 1180 1190 1200
VTEQREKIVL KNKLEVMTYW MNDYSKDARL ARLVAHQEKF PHLEHLIHKF

NKGVR
Length:1,205
Mass (Da):136,255
Last modified:February 6, 2013 - v4
Checksum:iC8C36AEA74128E69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD63635.2.
RefSeqiNP_510755.4. NM_078354.5.

Genome annotation databases

EnsemblMetazoaiC30G4.3; C30G4.3; WBGene00001537.
GeneIDi181745.
KEGGicel:CELE_C30G4.3.
UCSCiC30G4.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD63635.2.
RefSeqiNP_510755.4. NM_078354.5.

3D structure databases

ProteinModelPortaliQ18331.
SMRiQ18331. Positions 673-949, 987-1157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C30G4.3.

Proteomic databases

EPDiQ18331.
PaxDbiQ18331.
PRIDEiQ18331.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC30G4.3; C30G4.3; WBGene00001537.
GeneIDi181745.
KEGGicel:CELE_C30G4.3.
UCSCiC30G4.3. c. elegans.

Organism-specific databases

CTDi181745.
WormBaseiC30G4.3; CE48005; WBGene00001537; gcy-11.

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000118959.
HOGENOMiHOG000020750.
InParanoidiQ18331.
OMAiHENLNRF.
OrthoDBiEOG091G01DC.

Miscellaneous databases

PROiQ18331.

Gene expression databases

BgeeiWBGene00001537.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCY11_CAEEL
AccessioniPrimary (citable) accession number: Q18331
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: February 6, 2013
Last modified: September 7, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.