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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsY

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO4) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.UniRule annotation

Catalytic activityi

Acyl-phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + phosphate.UniRule annotation

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2782-MONOMER.
UniPathwayiUPA00085.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation
Alternative name(s):
Acyl-PO4 G3P acyltransferaseUniRule annotation
Acyl-phosphate--glycerol-3-phosphate acyltransferaseUniRule annotation
G3P acyltransferaseUniRule annotation (EC:2.3.1.n3UniRule annotation)
Short name:
GPATUniRule annotation
Lysophosphatidic acid synthaseUniRule annotation
Short name:
LPA synthaseUniRule annotation
Gene namesi
Name:plsYUniRule annotation
Ordered Locus Names:CD630_26310
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei122 – 142HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000641681 – 204Glycerol-3-phosphate acyltransferaseAdd BLAST204

Interactioni

Subunit structurei

Probably interacts with PlsX.UniRule annotation

Protein-protein interaction databases

STRINGi272563.CD2631.

Structurei

3D structure databases

ProteinModelPortaliQ182W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PlsY family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105K7Z. Bacteria.
COG0344. LUCA.
HOGENOMiHOG000283807.
KOiK08591.
OMAiHIWPVWL.

Family and domain databases

HAMAPiMF_01043. PlsY. 1 hit.
InterProiIPR003811. G3P_acylTferase_PlsY.
[Graphical view]
PANTHERiPTHR30309:SF0. PTHR30309:SF0. 1 hit.
PfamiPF02660. G3P_acyltransf. 1 hit.
[Graphical view]
SMARTiSM01207. G3P_acyltransf. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00023. TIGR00023. 1 hit.

Sequencei

Sequence statusi: Complete.

Q182W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIFSYIIIA VVAYLLGNIS TSYIVAKRIA GVDIRTQGSG NAGSTNVLRT
60 70 80 90 100
LGKRAGAMTF LGDVLKGVMA VLISEFAARL VGIDTLLAGY LAVICVVAGH
110 120 130 140 150
NWPAVLGFRG GKGVATSLGA MLAVNPVITL MCLAVFILVV AITKYVSLGS
160 170 180 190 200
VVGIGCSPIF MIMVKNKAGL IVALFLTASV IYNHRANIKR LLNGTERKIG

QKKE
Length:204
Mass (Da):21,442
Last modified:July 25, 2006 - v1
Checksum:i4C444009C32CAF61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69517.1.
RefSeqiWP_003426957.1. NZ_CP010905.1.
YP_001089142.1. NC_009089.1.

Genome annotation databases

EnsemblBacteriaiCAJ69517; CAJ69517; CD630_26310.
GeneIDi4913104.
KEGGicdf:CD630_26310.
pdc:CDIF630_02885.
PATRICi19443737. VBICloDif38397_2755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA. Translation: CAJ69517.1.
RefSeqiWP_003426957.1. NZ_CP010905.1.
YP_001089142.1. NC_009089.1.

3D structure databases

ProteinModelPortaliQ182W4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272563.CD2631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ69517; CAJ69517; CD630_26310.
GeneIDi4913104.
KEGGicdf:CD630_26310.
pdc:CDIF630_02885.
PATRICi19443737. VBICloDif38397_2755.

Phylogenomic databases

eggNOGiENOG4105K7Z. Bacteria.
COG0344. LUCA.
HOGENOMiHOG000283807.
KOiK08591.
OMAiHIWPVWL.

Enzyme and pathway databases

UniPathwayiUPA00085.
BioCyciPDIF272563:G12WB-2782-MONOMER.

Family and domain databases

HAMAPiMF_01043. PlsY. 1 hit.
InterProiIPR003811. G3P_acylTferase_PlsY.
[Graphical view]
PANTHERiPTHR30309:SF0. PTHR30309:SF0. 1 hit.
PfamiPF02660. G3P_acyltransf. 1 hit.
[Graphical view]
SMARTiSM01207. G3P_acyltransf. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00023. TIGR00023. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSY_PEPD6
AccessioniPrimary (citable) accession number: Q182W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 25, 2006
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.