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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPDIF272563:G12WB-2740-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:CD630_25840
OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
Taxonomic identifieri272563 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides
Proteomesi
  • UP000001978 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000200471 – 309Methionyl-tRNA formyltransferaseAdd BLAST309

Proteomic databases

PRIDEiQ182S2

Interactioni

Protein-protein interaction databases

STRINGi272563.CD2584

Structurei

3D structure databases

ProteinModelPortaliQ182S2
SMRiQ182S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q182S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVFMGTPD IAVPCLQKII DENYEILGVV TQPDKPKGRG KKLGMSPVKE
60 70 80 90 100
LAIENNIPVY QPVKARDKEF IDKIKSLNPD VIVVVAFGQI LPKEILEIPK
110 120 130 140 150
LGCINVHVSL LPKYRGAAPI NWVIINGEEK TGVTTMYMDE GLDTGDMILK
160 170 180 190 200
TEVNLDENIT AGELHDKMMN IGAETLKETL RLIEEGNAPR EVQNHEEFSY
210 220 230 240 250
APIMNKSLGN IDFSKSAREI HNLVRGVNPW PSAYTTYNDV IMKVWKTKVL
260 270 280 290 300
DEKSTKDVGT IIDVSKDGIK VSTIDNVLLI EEIQMPNKKR MLVGEYIKGN

TIETGLVLG
Length:309
Mass (Da):34,454
Last modified:July 25, 2006 - v1
Checksum:i34048B8E96BB9AF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM180355 Genomic DNA Translation: CAJ69473.1
RefSeqiWP_011861609.1, NZ_CP010905.2
YP_001089100.1, NC_009089.1

Genome annotation databases

EnsemblBacteriaiCAJ69473; CAJ69473; CD630_25840
GeneIDi31354183
4914705
KEGGicdf:CD630_25840
pdc:CDIF630_02837
PATRICifig|272563.120.peg.2725

Similar proteinsi

Entry informationi

Entry nameiFMT_PEPD6
AccessioniPrimary (citable) accession number: Q182S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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