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Q182K8

- SYL_PEPD6

UniProt

Q182K8 - SYL_PEPD6

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Peptoclostridium difficile (strain 630) (Clostridium difficile)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei569 – 5691ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCDIF272563:GJFE-2740-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CD630_25210
    OrganismiPeptoclostridium difficile (strain 630) (Clostridium difficile)
    Taxonomic identifieri272563 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaePeptoclostridium
    ProteomesiUP000001978: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Leucine--tRNA ligasePRO_1000091308Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272563.CD2521.

    Structurei

    3D structure databases

    ProteinModelPortaliQ182K8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi566 – 5705"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q182K8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVYNFKEVE SKWQKIWKDN NQYKMDTAQT EKPNYYTLEM FPYPSGKIHM    50
    GHVRNYSIGD VVARFKKMEG YNVLHPMGWD SFGLPAENAA IKHGIHPHKW 100
    TMENIEEMKE QLNLLGISYD WDKEVATSTP EYYRFTQEIF LKFLEHGLAY 150
    KKKSYVNWCP SCETVLANEQ VVQGACERCK ATVLKKDLEQ WYFKTTEFAE 200
    ELLNDLDTLD GWPEKVKTMQ KNWIGKSTGA DLVFDIDGTD KSMTVFTTRP 250
    DTTYGVTYMV LAPEHELVKE LVAGTEYEAD VEAFVQKMHT MTEIERTAAD 300
    VEKEGMFIGR YVINPLNGKK VPLWIANYVL VEYGTGAIMA VPAHDERDRD 350
    FAEKYNLDII DVITEDNKMI NSEEFNGLDA SEGFEGIIDK LEKEGRGKRT 400
    INYRLRDWLV SRQRYWGCPI PVVYCDECGI VPVKKEDLPV LLPTDVEFTG 450
    KGESPLTTSK QFMSTTCPHC GKPARREVDT MDTFVDSSWY FLRYVDSNNE 500
    NEPFSKELVN RWHPVDQYIG GVEHAIMHLL YARWFVKAFK SMGMVDFNEP 550
    FKNLLTQGMV LMDGSKMSKS KGNTVSPMDI IDEYGADTAR LFVLFAAPPE 600
    RDLDWSEQGV DGCFRFLNRV YRLVDELADV VKKDVEFGEL NSQDKDMRYT 650
    IHSTLKKVTA DLSEKFGFNT AISALMELIN DMYKYKELDN INEAVIKEGV 700
    QTIVTIIAPF APHLGEELWT MIGKEGSVFD IDWPKYDEKA LVKDEIEVVV 750
    QVNGKVRGKL TVNSNISKDE MEKVALEDEK IKGLVEGKTI VKVVAVPKKL 800
    VNIVVK 806
    Length:806
    Mass (Da):92,433
    Last modified:July 25, 2006 - v1
    Checksum:i48AEB19A0A21102C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ69408.1.
    RefSeqiYP_001089035.1. NC_009089.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ69408; CAJ69408; CD630_25210.
    GeneIDi4915278.
    KEGGicdf:CD630_25210.
    PATRICi19443515. VBICloDif38397_2644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM180355 Genomic DNA. Translation: CAJ69408.1 .
    RefSeqi YP_001089035.1. NC_009089.1.

    3D structure databases

    ProteinModelPortali Q182K8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272563.CD2521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ69408 ; CAJ69408 ; CD630_25210 .
    GeneIDi 4915278.
    KEGGi cdf:CD630_25210.
    PATRICi 19443515. VBICloDif38397_2644.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CDIF272563:GJFE-2740-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 630.

    Entry informationi

    Entry nameiSYL_PEPD6
    AccessioniPrimary (citable) accession number: Q182K8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3