Q182I1 (SELD_CLOD6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenide, water dikinase
EC=2.7.9.3

Alternative name(s):
Selenium donor protein
Selenophosphate synthase

Gene names

Name:	selD
Ordered Locus Names:	CD630_24960

Organism

Clostridium difficile (strain 630) [Complete proteome] [HAMAP]

Taxonomic identifier

272563 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity. HAMAP MF_00625
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate. HAMAP MF_00625
Cofactor	Magnesium By similarity. HAMAP MF_00625
Sequence similarities	Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Sequence caution	The sequence CAJ69382.2 differs from that shown. Reason: Erroneous termination at position 17. Translated as Sec.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	ATP-binding Magnesium Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW selenide, water dikinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Selenide, water dikinase HAMAP MF_00625		PRO_0000318667
Regions
	Nucleotide binding	229 – 235	7	ATP Potential
Sites
	Active site	17	1	Potential
	Site	20	1	Important for catalytic activity By similarity
Amino acid modifications
	Non-standard residue	17	1	Selenocysteine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q182I1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 47FC13D819C36FC4	FASTA	348	37,331
	10 20 30 40 50 60 MKKEQKKLTE MTTAGGUAAK IGPEVLASVL SQLPKNDNIE NLLVGLDTAD DAAVYKLNDD 70 80 90 100 110 120 MALIQTLDFF TPMVDDPYVF GQIAASNSLS DVYAMGGKPL VAMNIVCFPS CHDMDVLAEI 130 140 150 160 170 180 LKGGFDKVKE SGALLVGGHT VDDKEPKYGL SVSGIVSPNK VLSNATAKPG DKLIITKPIG 190 200 210 220 230 240 VGVLNTAMKE GMVEQHIADK VIEIMIHLNK YAAMSFEKFD VNSVTDITGF GLLGHTLEMA 250 260 270 280 290 300 KASEVSIEIE SKHVPIIEGA IEMAQMGIIP AGMYKNMHYV SKDVEVVGNI EVAVQDILYD 310 320 330 340 PQTSGGLLIS VKEELAEELV KDMKLNGAIE AKIIGSVVPK GEKYITVL

References

[1]

"The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome." Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H., Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N., Brooks K., Chillingworth T. , Cronin A., Davis P., Dowd L., Fraser A., Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K., Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L., Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J. Nat. Genet. 38:779-786(2006) [PubMed: 16804543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 630.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM180355 Genomic DNA. Translation: CAJ69382.2. Sequence problems.
RefSeq	YP_001089009.1. NC_009089.1.
3D structure databases
ProteinModelPortal	Q182I1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q182I1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4916621.
GenomeReviews	Gene locus CD2496 in contig AM180355_GR.
KEGG	cdf:CD2496.
PATRIC	19443461. VBICloDif38397_2617.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0709.
HOGENOM	HBG383791.
ProtClustDB	CLSK2535291.
Family and domain databases
HAMAP	MF_00625. SelD. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR004536. SelD. IPR023061. SelD_I. [Graphical view]
KO	K01008.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00476. SelD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SELD_CLOD6

Accession

Primary (citable) accession number: Q182I1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program