ID   Q182E6_CLOD6            Unreviewed;       311 AA.
AC   Q182E6;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=Glucokinase, ROK family {ECO:0000313|EMBL:CAJ69346.1};
DE            EC=2.7.1.- {ECO:0000313|EMBL:CAJ69346.1};
GN   OrderedLocusNames=CD630_24590 {ECO:0000313|EMBL:CAJ69346.1};
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69346.1, ECO:0000313|Proteomes:UP000001978};
RN   [1] {ECO:0000313|EMBL:CAJ69346.1, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ69346.1,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC       {ECO:0000256|ARBA:ARBA00006479}.
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DR   EMBL; AM180355; CAJ69346.1; -; Genomic_DNA.
DR   RefSeq; WP_003416574.1; NZ_JAUPES010000003.1.
DR   RefSeq; YP_001088973.1; NC_009089.1.
DR   AlphaFoldDB; Q182E6; -.
DR   STRING; 272563.CD630_24590; -.
DR   EnsemblBacteria; CAJ69346; CAJ69346; CD630_24590.
DR   GeneID; 66354857; -.
DR   KEGG; cdf:CD630_24590; -.
DR   KEGG; pdc:CDIF630_02705; -.
DR   PATRIC; fig|272563.120.peg.2597; -.
DR   eggNOG; COG1940; Bacteria.
DR   OrthoDB; 9810372at2; -.
DR   PhylomeDB; Q182E6; -.
DR   BioCyc; PDIF272563:G12WB-2613-MONOMER; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW   Transferase {ECO:0000313|EMBL:CAJ69346.1}.
SQ   SEQUENCE   311 AA;  33610 MW;  731B47875537373C CRC64;
     MYYIGVDIGG TGIQAGVVDN YGKIIFRSEC KTVIEKGFEG ILNDIKIMIY KLLEDNKLTM
     SDIKSIGFGV PGFINKEGLV TCVNLKWNKK AFNKELKRRF PDVEIHGEND ATVAALGEAK
     FGSMKGANVG VLYTLGTGVG GGIVINQKVF SGAHGLGSEI GHQIIGENYF NCNCGNNGCV
     ETFCSATAII KYSQKLIEEG EKSRILDLAE GNLENVNAKM VFDAYRENDL VAIKVINRFK
     EYLAKTFANT INSLDPEIIS IGGGISKSSD IILDGIEDLV RKFVLYKTED IATITCATLG
     SDAGIIGAAF L
//