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Protein

Transient receptor potential cation channel subfamily A member 1 homolog

Gene

trpa-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport

Enzyme and pathway databases

ReactomeiR-CEL-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.6.5. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily A member 1 homolog
Gene namesi
Name:trpa-1
ORF Names:C29E6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC29E6.2a; CE42588; WBGene00007801; trpa-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 811CytoplasmicSequence analysisAdd BLAST811
Transmembranei812 – 832Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini833 – 870ExtracellularSequence analysisAdd BLAST38
Transmembranei871 – 891Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini892 – 894CytoplasmicSequence analysis3
Transmembranei895 – 915Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini916 – 932ExtracellularSequence analysisAdd BLAST17
Transmembranei933 – 953Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini954 – 975CytoplasmicSequence analysisAdd BLAST22
Transmembranei976 – 996Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini997 – 1004ExtracellularSequence analysis8
Intramembranei1005 – 1025Pore-formingBy similarityAdd BLAST21
Topological domaini1026 – 1048ExtracellularSequence analysisAdd BLAST23
Transmembranei1049 – 1069Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1070 – 1193CytoplasmicSequence analysisAdd BLAST124

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: WormBase
  • non-motile cilium Source: WormBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Worms exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153721 – 1211Transient receptor potential cation channel subfamily A member 1 homologAdd BLAST1211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi856N-linked (GlcNAc...)Sequence analysis1
Glycosylationi863N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ18297.
PaxDbiQ18297.
PRIDEiQ18297.

Expressioni

Tissue specificityi

Expressed in many sensory neurons, including OLQ and IL1 neurons.1 Publication

Gene expression databases

BgeeiWBGene00007801.
ExpressionAtlasiQ18297. baseline and differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-61523N.
STRINGi6239.C29E6.2.

Structurei

3D structure databases

ProteinModelPortaliQ18297.
SMRiQ18297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 79ANK 1Add BLAST31
Repeati83 – 112ANK 2Add BLAST30
Repeati116 – 169ANK 3Add BLAST54
Repeati173 – 202ANK 4Add BLAST30
Repeati206 – 235ANK 5Add BLAST30
Repeati239 – 270ANK 6Add BLAST32
Repeati277 – 306ANK 7Add BLAST30
Repeati311 – 340ANK 8Add BLAST30
Repeati344 – 374ANK 9Add BLAST31
Repeati378 – 407ANK 10Add BLAST30
Repeati411 – 440ANK 11Add BLAST30
Repeati473 – 502ANK 12Add BLAST30
Repeati506 – 535ANK 13Add BLAST30
Repeati540 – 569ANK 14Add BLAST30
Repeati573 – 602ANK 15Add BLAST30
Repeati605 – 634ANK 16Add BLAST30
Repeati638 – 669ANK 17Add BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1149 – 1191Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi943 – 1052Phe-richAdd BLAST110

Sequence similaritiesi

Contains 17 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0510. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00850000132305.
HOGENOMiHOG000017923.
InParanoidiQ18297.
OMAiLLMKDEM.
OrthoDBiEOG091G05TN.
PhylomeDBiQ18297.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF12796. Ank_2. 5 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 17 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL
60 70 80 90 100
RSIIHQSARE GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV
110 120 130 140 150
KLLLSKNALP NTKNREGDTP LHIASKYIYG YSDICSIIDE DQADSARKYN
160 170 180 190 200
TATKKIINAL VSENAEIDPV NKYQLTPLHY AAMKSNFSAL HALIKLKADV
210 220 230 240 250
DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL NTVFHIVALR
260 270 280 290 300
GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM
310 320 330 340 350
EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH
360 370 380 390 400
VAAQMNQLEV VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA
410 420 430 440 450
KKANLTITDK DERTPVFIGA KFNALSSVEY ILDHLRKKNK ETERSALKSP
460 470 480 490 500
TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI VASNGYLEMM QLLQKHGASI
510 520 530 540 550
TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM GNSALHLAAR
560 570 580 590 600
SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI
610 620 630 640 650
ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND
660 670 680 690 700
HKDVARAFLE TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE
710 720 730 740 750
LASFVMDNCI EKSKEETDST QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG
760 770 780 790 800
CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP LKLMADAEKL HLLNHPLSKA
810 820 830 840 850
LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN VWNEESYYDS
860 870 880 890 900
EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN
910 920 930 940 950
WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL
960 970 980 990 1000
FMIRKMPRFG IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE
1010 1020 1030 1040 1050
FSTIFMSPLK TTVMMIGEFE FTGIFHGDET THAEKMFGPA HTAVACALFF
1060 1070 1080 1090 1100
FFCIIMTILL MNLLVGLAVD DIKGVQEKAE LKRLAMQVDL VLQIEASLHF
1110 1120 1130 1140 1150
FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS VSTDPEIDEM
1160 1170 1180 1190 1200
YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL
1210
NINIELEEKD N
Length:1,211
Mass (Da):138,450
Last modified:July 22, 2008 - v5
Checksum:i6AB5A06F69097201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72504 Genomic DNA. Translation: CAA96603.3.
PIRiT19552.
RefSeqiNP_502249.3. NM_069848.4.
UniGeneiCel.5648.

Genome annotation databases

EnsemblMetazoaiC29E6.2a; C29E6.2a; WBGene00007801.
GeneIDi178118.
KEGGicel:CELE_C29E6.2.
UCSCiC29E6.2. c. elegans.

Cross-referencesi

Web resourcesi

Protein Spotlight

The power behind pain - Issue 82 of May 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72504 Genomic DNA. Translation: CAA96603.3.
PIRiT19552.
RefSeqiNP_502249.3. NM_069848.4.
UniGeneiCel.5648.

3D structure databases

ProteinModelPortaliQ18297.
SMRiQ18297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61523N.
STRINGi6239.C29E6.2.

Protein family/group databases

TCDBi1.A.4.6.5. the transient receptor potential ca(2+) channel (trp-cc) family.

Proteomic databases

EPDiQ18297.
PaxDbiQ18297.
PRIDEiQ18297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC29E6.2a; C29E6.2a; WBGene00007801.
GeneIDi178118.
KEGGicel:CELE_C29E6.2.
UCSCiC29E6.2. c. elegans.

Organism-specific databases

CTDi178118.
WormBaseiC29E6.2a; CE42588; WBGene00007801; trpa-1.

Phylogenomic databases

eggNOGiKOG0510. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00850000132305.
HOGENOMiHOG000017923.
InParanoidiQ18297.
OMAiLLMKDEM.
OrthoDBiEOG091G05TN.
PhylomeDBiQ18297.

Enzyme and pathway databases

ReactomeiR-CEL-3295583. TRP channels.

Miscellaneous databases

PROiQ18297.

Gene expression databases

BgeeiWBGene00007801.
ExpressionAtlasiQ18297. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF12796. Ank_2. 5 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 17 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPA1_CAEEL
AccessioniPrimary (citable) accession number: Q18297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 130 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.