Reviewed,
UniProtKB/Swiss-Prot Q18297 (TRPA1_CAEEL)
Last modified
November 24, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Transient receptor potential cation channel subfamily A member 1 homolog | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 1211 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. Ref.2 |
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Expressed in many sensory neurons, including OLQ and IL1 neurons. Ref.2 |
| Disruption phenotype | Worms exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors. Ref.2 |
| Sequence similarities | Belongs to the transient receptor family. Contains 16 ANK repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Sensory transduction Transport |
| Cellular component | Membrane |
| Domain | ANK repeat Repeat Transmembrane |
| Molecular function | Ionic channel |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase ion transportInferred from electronic annotation. Source: UniProtKB-KW reproductionInferred from mutant phenotype. Source: WormBase response to stimulusInferred from electronic annotation. Source: UniProtKB-KW transmembrane transportInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1211 | 1211 | Transient receptor potential cation channel subfamily A member 1 homolog | PRO_0000215372 | |||||
Regions | |||||||||
| Topological domain | 1 – 811 | 811 | Cytoplasmic Potential | ||||||
| Transmembrane | 812 – 832 | 21 | Potential | ||||||
| Topological domain | 833 – 870 | 38 | Extracellular Potential | ||||||
| Transmembrane | 871 – 891 | 21 | Potential | ||||||
| Topological domain | 892 – 894 | 3 | Cytoplasmic Potential | ||||||
| Transmembrane | 895 – 915 | 21 | Potential | ||||||
| Topological domain | 916 – 932 | 17 | Extracellular Potential | ||||||
| Transmembrane | 933 – 953 | 21 | Potential | ||||||
| Topological domain | 954 – 975 | 22 | Cytoplasmic Potential | ||||||
| Transmembrane | 976 – 996 | 21 | Potential | ||||||
| Topological domain | 997 – 1048 | 52 | Extracellular Potential | ||||||
| Transmembrane | 1049 – 1069 | 21 | Potential | ||||||
| Topological domain | 1070 – 1193 | 124 | Cytoplasmic Potential | ||||||
| Repeat | 49 – 79 | 31 | ANK 1 | ||||||
| Repeat | 83 – 112 | 30 | ANK 2 | ||||||
| Repeat | 116 – 169 | 54 | ANK 3 | ||||||
| Repeat | 173 – 202 | 30 | ANK 4 | ||||||
| Repeat | 206 – 235 | 30 | ANK 5 | ||||||
| Repeat | 239 – 270 | 32 | ANK 6 | ||||||
| Repeat | 277 – 306 | 30 | ANK 7 | ||||||
| Repeat | 311 – 340 | 30 | ANK 8 | ||||||
| Repeat | 344 – 374 | 31 | ANK 9 | ||||||
| Repeat | 378 – 407 | 30 | ANK 10 | ||||||
| Repeat | 411 – 440 | 30 | ANK 11 | ||||||
| Repeat | 473 – 502 | 30 | ANK 12 | ||||||
| Repeat | 506 – 535 | 30 | ANK 13 | ||||||
| Repeat | 540 – 569 | 30 | ANK 14 | ||||||
| Repeat | 573 – 602 | 30 | ANK 15 | ||||||
| Repeat | 605 – 634 | 30 | ANK 16 | ||||||
| Repeat | 638 – 669 | 32 | ANK 17 | ||||||
| Compositional bias | 943 – 1052 | 110 | Phe-rich | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 856 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 863 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [2] | "Caenorhabditis elegans TRPA-1 functions in mechanosensation." Kindt K.S., Viswanath V., Macpherson L., Quast K., Hu H., Patapoutian A., Schafer W.R. Nat. Neurosci. 10:568-577(2007) [PubMed: 17450139] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z72504 Genomic DNA. Translation: CAA96603.3. | |
| PIR | T19552. |
| RefSeq | NP_502249.3. |
| UniGene | Cel.5648 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | C29E6.2; C29E6.2; C29E6.2; Caenorhabditis elegans. [Genome view] |
| GeneID | 178118. |
| KEGG | cel:C29E6.2. |
| NMPDR | fig|6239.3.peg.15329. |
| UCSC | C29E6.2. c. elegans. |
Organism-specific databases | |
| CTD | 178118. |
| WormBase | WBGene00007801. trpa-1. |
| WormPep | C29E6.2. CE42588. [WorfDB] |
Gene expression databases | |
| ArrayExpress | Q18297. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 3 hits. |
| Pfam | PF00023. Ank. 16 hits. PF00520. Ion_trans. 1 hit. [Graphical view] |
| SMART | SM00248. ANK. 17 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 9 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TRPA1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q18297 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


