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Q18297 (TRPA1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transient receptor potential cation channel subfamily A member 1 homolog
Gene names
Name:trpa-1
ORF Names:C29E6.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1211 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed in many sensory neurons, including OLQ and IL1 neurons. Ref.2

Disruption phenotype

Worms exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors. Ref.2

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. [View classification]

Contains 17 ANK repeats.

Ontologies

Keywords
   Biological processIon transport
Sensory transduction
Transport
   Cellular componentMembrane
   DomainANK repeat
Repeat
Transmembrane
Transmembrane helix
   Molecular functionIon channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stimulus

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionion channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12111211Transient receptor potential cation channel subfamily A member 1 homolog
PRO_0000215372

Regions

Topological domain1 – 811811Cytoplasmic Potential
Transmembrane812 – 83221Helical; Potential
Topological domain833 – 87038Extracellular Potential
Transmembrane871 – 89121Helical; Potential
Topological domain892 – 8943Cytoplasmic Potential
Transmembrane895 – 91521Helical; Potential
Topological domain916 – 93217Extracellular Potential
Transmembrane933 – 95321Helical; Potential
Topological domain954 – 97522Cytoplasmic Potential
Transmembrane976 – 99621Helical; Potential
Topological domain997 – 104852Extracellular Potential
Transmembrane1049 – 106921Helical; Potential
Topological domain1070 – 1193124Cytoplasmic Potential
Repeat49 – 7931ANK 1
Repeat83 – 11230ANK 2
Repeat116 – 16954ANK 3
Repeat173 – 20230ANK 4
Repeat206 – 23530ANK 5
Repeat239 – 27032ANK 6
Repeat277 – 30630ANK 7
Repeat311 – 34030ANK 8
Repeat344 – 37431ANK 9
Repeat378 – 40730ANK 10
Repeat411 – 44030ANK 11
Repeat473 – 50230ANK 12
Repeat506 – 53530ANK 13
Repeat540 – 56930ANK 14
Repeat573 – 60230ANK 15
Repeat605 – 63430ANK 16
Repeat638 – 66932ANK 17
Compositional bias943 – 1052110Phe-rich

Amino acid modifications

Glycosylation8561N-linked (GlcNAc...) Potential
Glycosylation8631N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q18297 [UniParc].

Last modified July 22, 2008. Version 5.
Checksum: 6AB5A06F69097201

FASTA1,211138,450
        10         20         30         40         50         60 
MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL RSIIHQSARE 

        70         80         90        100        110        120 
GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV KLLLSKNALP NTKNREGDTP 

       130        140        150        160        170        180 
LHIASKYIYG YSDICSIIDE DQADSARKYN TATKKIINAL VSENAEIDPV NKYQLTPLHY 

       190        200        210        220        230        240 
AAMKSNFSAL HALIKLKADV DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL 

       250        260        270        280        290        300 
NTVFHIVALR GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM 

       310        320        330        340        350        360 
EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH VAAQMNQLEV 

       370        380        390        400        410        420 
VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA KKANLTITDK DERTPVFIGA 

       430        440        450        460        470        480 
KFNALSSVEY ILDHLRKKNK ETERSALKSP TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI 

       490        500        510        520        530        540 
VASNGYLEMM QLLQKHGASI TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM 

       550        560        570        580        590        600 
GNSALHLAAR SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI 

       610        620        630        640        650        660 
ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND HKDVARAFLE 

       670        680        690        700        710        720 
TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE LASFVMDNCI EKSKEETDST 

       730        740        750        760        770        780 
QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP 

       790        800        810        820        830        840 
LKLMADAEKL HLLNHPLSKA LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN 

       850        860        870        880        890        900 
VWNEESYYDS EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN 

       910        920        930        940        950        960 
WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL FMIRKMPRFG 

       970        980        990       1000       1010       1020 
IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE FSTIFMSPLK TTVMMIGEFE 

      1030       1040       1050       1060       1070       1080 
FTGIFHGDET THAEKMFGPA HTAVACALFF FFCIIMTILL MNLLVGLAVD DIKGVQEKAE 

      1090       1100       1110       1120       1130       1140 
LKRLAMQVDL VLQIEASLHF FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS 

      1150       1160       1170       1180       1190       1200 
VSTDPEIDEM YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL 

      1210 
NINIELEEKD N 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Caenorhabditis elegans TRPA-1 functions in mechanosensation."
Kindt K.S., Viswanath V., Macpherson L., Quast K., Hu H., Patapoutian A., Schafer W.R.
Nat. Neurosci. 10:568-577(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

The power behind pain - Issue 82 of May 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72504 Genomic DNA. Translation: CAA96603.3.
PIRT19552.
RefSeqNP_502249.3. NM_069848.4.

3D structure databases

ProteinModelPortalQ18297.
SMRQ18297. Positions 49-676.
ModBaseSearch...

Proteomic databases

PaxDbQ18297.
PRIDEQ18297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC29E6.2; C29E6.2; C29E6.2.
GeneID178118.
KEGGcel:CELE_C29E6.2.
UCSCC29E6.2. c. elegans.

Organism-specific databases

CTD178118.
WormBaseC29E6.2; CE42588; WBGene00007801; trpa-1.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00690000102150.
HOGENOMHOG000017923.
InParanoidQ18297.
KOK04984.
OMADEEANTA.

Gene expression databases

ArrayExpressQ18297.

Family and domain databases

Gene3D1.25.40.20. 5 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamPF00023. Ank. 7 hits.
PF12796. Ank_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 17 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 2 hits.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio899788.

Entry information

Entry nameTRPA1_CAEEL
AccessionPrimary (citable) accession number: Q18297
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 22, 2008
Last modified: May 1, 2013
This is version 97 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries