Transient receptor potential cation channel subfamily A member 1 homolog

Names and origin

Protein names

Recommended name:
Transient receptor potential cation channel subfamily A member 1 homolog

Gene names

Name:	trpa-1
ORF Names:	C29E6.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length	1211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	Expressed in many sensory neurons, including OLQ and IL1 neurons. Ref.2
Disruption phenotype	Worms exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors. Ref.2
Sequence similarities	Belongs to the transient receptor family. Contains 16 ANK repeats.

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Ontologies

Keywords
Biological process	Ion transport Sensory transduction Transport
Cellular component	Membrane
Domain	ANK repeat Repeat Transmembrane
Molecular function	Ionic channel
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase ion transport Inferred from electronic annotation. Source: UniProtKB-KW reproduction Inferred from mutant phenotype. Source: WormBase response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1211

1211

Transient receptor potential cation channel subfamily A member 1 homolog

PRO_0000215372

Regions

Topological domain

1 – 811

811

Cytoplasmic Potential

Transmembrane

812 – 832

21

Potential

Topological domain

833 – 870

38

Extracellular Potential

Transmembrane

871 – 891

21

Potential

Topological domain

892 – 894

3

Cytoplasmic Potential

Transmembrane

895 – 915

21

Potential

Topological domain

916 – 932

17

Extracellular Potential

Transmembrane

933 – 953

21

Potential

Topological domain

954 – 975

22

Cytoplasmic Potential

Transmembrane

976 – 996

21

Potential

Topological domain

997 – 1048

52

Extracellular Potential

Transmembrane

1049 – 1069

21

Potential

Topological domain

1070 – 1193

124

Cytoplasmic Potential

Repeat

49 – 79

31

ANK 1

Repeat

83 – 112

30

ANK 2

Repeat

116 – 169

54

ANK 3

Repeat

173 – 202

30

ANK 4

Repeat

206 – 235

30

ANK 5

Repeat

239 – 270

32

ANK 6

Repeat

277 – 306

30

ANK 7

Repeat

311 – 340

30

ANK 8

Repeat

344 – 374

31

ANK 9

Repeat

378 – 407

30

ANK 10

Repeat

411 – 440

30

ANK 11

Repeat

473 – 502

30

ANK 12

Repeat

506 – 535

30

ANK 13

Repeat

540 – 569

30

ANK 14

Repeat

573 – 602

30

ANK 15

Repeat

605 – 634

30

ANK 16

Repeat

638 – 669

32

ANK 17

Compositional bias

943 – 1052

110

Phe-rich

Amino acid modifications

Glycosylation

856

1

N-linked (GlcNAc...) Potential

Glycosylation

863

1

N-linked (GlcNAc...) Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q18297-1 [UniParc].

Last modified July 22, 2008. Version 5.
Checksum: 6AB5A06F69097201
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FASTA

1,211

138,450

        10         20         30         40         50         60 
MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL RSIIHQSARE 

        70         80         90        100        110        120 
GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV KLLLSKNALP NTKNREGDTP 

       130        140        150        160        170        180 
LHIASKYIYG YSDICSIIDE DQADSARKYN TATKKIINAL VSENAEIDPV NKYQLTPLHY 

       190        200        210        220        230        240 
AAMKSNFSAL HALIKLKADV DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL 

       250        260        270        280        290        300 
NTVFHIVALR GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM 

       310        320        330        340        350        360 
EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH VAAQMNQLEV 

       370        380        390        400        410        420 
VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA KKANLTITDK DERTPVFIGA 

       430        440        450        460        470        480 
KFNALSSVEY ILDHLRKKNK ETERSALKSP TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI 

       490        500        510        520        530        540 
VASNGYLEMM QLLQKHGASI TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM 

       550        560        570        580        590        600 
GNSALHLAAR SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI 

       610        620        630        640        650        660 
ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND HKDVARAFLE 

       670        680        690        700        710        720 
TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE LASFVMDNCI EKSKEETDST 

       730        740        750        760        770        780 
QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP 

       790        800        810        820        830        840 
LKLMADAEKL HLLNHPLSKA LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN 

       850        860        870        880        890        900 
VWNEESYYDS EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN 

       910        920        930        940        950        960 
WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL FMIRKMPRFG 

       970        980        990       1000       1010       1020 
IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE FSTIFMSPLK TTVMMIGEFE 

      1030       1040       1050       1060       1070       1080 
FTGIFHGDET THAEKMFGPA HTAVACALFF FFCIIMTILL MNLLVGLAVD DIKGVQEKAE 

      1090       1100       1110       1120       1130       1140 
LKRLAMQVDL VLQIEASLHF FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS 

      1150       1160       1170       1180       1190       1200 
VSTDPEIDEM YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL 

      1210 
NINIELEEKD N

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Caenorhabditis elegans TRPA-1 functions in mechanosensation." Kindt K.S., Viswanath V., Macpherson L., Quast K., Hu H., Patapoutian A., Schafer W.R. Nat. Neurosci. 10:568-577(2007) [PubMed: 17450139] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

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Web resources

Protein Spotlight

The power behind pain - Issue 82 of May 2007

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Cross-references

Sequence databases
	Z72504 Genomic DNA. Translation: CAA96603.3.
PIR	T19552.
RefSeq	NP_502249.3.
UniGene	Cel.5648
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	C29E6.2; C29E6.2; C29E6.2; Caenorhabditis elegans. [Genome view]
GeneID	178118.
KEGG	cel:C29E6.2.
NMPDR	fig\|6239.3.peg.15329.
UCSC	C29E6.2. c. elegans.
Organism-specific databases
CTD	178118.
WormBase	WBGene00007801. trpa-1.
WormPep	C29E6.2. CE42588. [WorfDB]
Gene expression databases
ArrayExpress	Q18297.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 3 hits.
Pfam	PF00023. Ank. 16 hits. PF00520. Ion_trans. 1 hit. [Graphical view]
SMART	SM00248. ANK. 17 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 9 hits. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

TRPA1_CAEEL

Accession

Primary (citable) accession number: Q18297

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 22, 2008
Last modified:	November 24, 2009
This is version 67 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

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Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents