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Protein

Transient receptor potential cation channel subfamily A member 1 homolog

Gene

trpa-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport

Enzyme and pathway databases

ReactomeiR-CEL-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.6.5. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily A member 1 homolog
Gene namesi
Name:trpa-1
ORF Names:C29E6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC29E6.2a; CE42588; WBGene00007801; trpa-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 811811CytoplasmicSequence analysisAdd
BLAST
Transmembranei812 – 83221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini833 – 87038ExtracellularSequence analysisAdd
BLAST
Transmembranei871 – 89121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini892 – 8943CytoplasmicSequence analysis
Transmembranei895 – 91521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini916 – 93217ExtracellularSequence analysisAdd
BLAST
Transmembranei933 – 95321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini954 – 97522CytoplasmicSequence analysisAdd
BLAST
Transmembranei976 – 99621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini997 – 10048ExtracellularSequence analysis
Intramembranei1005 – 102521Pore-formingBy similarityAdd
BLAST
Topological domaini1026 – 104823ExtracellularSequence analysisAdd
BLAST
Transmembranei1049 – 106921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini1070 – 1193124CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: WormBase
  • nonmotile primary cilium Source: WormBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Worms exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12111211Transient receptor potential cation channel subfamily A member 1 homologPRO_0000215372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence analysis
Glycosylationi863 – 8631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ18297.
PaxDbiQ18297.
PRIDEiQ18297.

Expressioni

Tissue specificityi

Expressed in many sensory neurons, including OLQ and IL1 neurons.1 Publication

Gene expression databases

ExpressionAtlasiQ18297. baseline and differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-61523N.
STRINGi6239.C29E6.2.

Structurei

3D structure databases

ProteinModelPortaliQ18297.
SMRiQ18297. Positions 49-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati49 – 7931ANK 1Add
BLAST
Repeati83 – 11230ANK 2Add
BLAST
Repeati116 – 16954ANK 3Add
BLAST
Repeati173 – 20230ANK 4Add
BLAST
Repeati206 – 23530ANK 5Add
BLAST
Repeati239 – 27032ANK 6Add
BLAST
Repeati277 – 30630ANK 7Add
BLAST
Repeati311 – 34030ANK 8Add
BLAST
Repeati344 – 37431ANK 9Add
BLAST
Repeati378 – 40730ANK 10Add
BLAST
Repeati411 – 44030ANK 11Add
BLAST
Repeati473 – 50230ANK 12Add
BLAST
Repeati506 – 53530ANK 13Add
BLAST
Repeati540 – 56930ANK 14Add
BLAST
Repeati573 – 60230ANK 15Add
BLAST
Repeati605 – 63430ANK 16Add
BLAST
Repeati638 – 66932ANK 17Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1149 – 119143Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi943 – 1052110Phe-richAdd
BLAST

Sequence similaritiesi

Contains 17 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0510. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129770.
HOGENOMiHOG000017923.
InParanoidiQ18297.
OMAiLLMKDEM.
OrthoDBiEOG7P02H2.
PhylomeDBiQ18297.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF12796. Ank_2. 5 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 17 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKSLGLDV RLELEGLISN DDTIRSEKDG RQASIFRVAE LDARTEADNL
60 70 80 90 100
RSIIHQSARE GNVNALQEAL LKAPLAVNAQ DGDFMTPLHY AARYGNYDAV
110 120 130 140 150
KLLLSKNALP NTKNREGDTP LHIASKYIYG YSDICSIIDE DQADSARKYN
160 170 180 190 200
TATKKIINAL VSENAEIDPV NKYQLTPLHY AAMKSNFSAL HALIKLKADV
210 220 230 240 250
DAEDDNKMTP LLLACVHGSQ EIIQELIKAN SNVTKRDQRL NTVFHIVALR
260 270 280 290 300
GEPEYLEMMM DHDPVEAIKA LNLFNNEKKT PLRMAVEGNH PETLKKILQM
310 320 330 340 350
EKKNSCKWMD REKELIHFAA EKGFLEVLKA LVEAGGNKNE LNEVKAVPLH
360 370 380 390 400
VAAQMNQLEV VSYLIEEEKD NIDVVDEQGL TPLMMAVTHD SKKCVEYLIA
410 420 430 440 450
KKANLTITDK DERTPVFIGA KFNALSSVEY ILDHLRKKNK ETERSALKSP
460 470 480 490 500
TRNTLRIVSE DVRRTMVNMV DRDQNTPMHI VASNGYLEMM QLLQKHGASI
510 520 530 540 550
TQVNEDEETA LHRAAIGGQT GAVRQLLEWD IRLLLMKDEM GNSALHLAAR
560 570 580 590 600
SGHDATTKVL LDNGADKEAK NSYQKTPLQV AVDSGKLETC QRLVAKGAQI
610 620 630 640 650
ESSSDTKTVL HTAAFYGNES IVRYFIAEGV TIDRRDEEGK TAFDIACEND
660 670 680 690 700
HKDVARAFLE TDQWKNLMIP CDVIPLDKHR NPVNMKRRTP FRTLLTKFPE
710 720 730 740 750
LASFVMDNCI EKSKEETDST QSVAYNFEFL DDTYMMRCVS DDGTGEQLIG
760 770 780 790 800
CKSAYDEDFK LEKDAQSYAS NYDRVYKYHP LKLMADAEKL HLLNHPLSKA
810 820 830 840 850
LLKYKWNRLG RPMYYFALFM YLVFIVSLTQ YVRHTKAPYN VWNEESYYDS
860 870 880 890 900
EYFDENETCP QINTTKPDVV WKIIIQTLAV CQILVECFQL FQRKFAYLVN
910 920 930 940 950
WENWIDCFIY STALITVYDF SECSATSGVR QNWQWILAAL CIFFGWINLL
960 970 980 990 1000
FMIRKMPRFG IFVVMFVDIV KTFFRFFPVF VLFIIAFSSS FYVILQNRPE
1010 1020 1030 1040 1050
FSTIFMSPLK TTVMMIGEFE FTGIFHGDET THAEKMFGPA HTAVACALFF
1060 1070 1080 1090 1100
FFCIIMTILL MNLLVGLAVD DIKGVQEKAE LKRLAMQVDL VLQIEASLHF
1110 1120 1130 1140 1150
FIQRTKKYAT CRYATFPYGK LHKTGFAGWW SNFRRRFGLS VSTDPEIDEM
1160 1170 1180 1190 1200
YEREAEFTSE MTQKLQNQAA KLKNIQENID VMYEKQVRLE AIIAKLATGL
1210
NINIELEEKD N
Length:1,211
Mass (Da):138,450
Last modified:July 22, 2008 - v5
Checksum:i6AB5A06F69097201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72504 Genomic DNA. Translation: CAA96603.3.
PIRiT19552.
RefSeqiNP_502249.3. NM_069848.4.
UniGeneiCel.5648.

Genome annotation databases

EnsemblMetazoaiC29E6.2a; C29E6.2a; WBGene00007801.
GeneIDi178118.
KEGGicel:CELE_C29E6.2.
UCSCiC29E6.2. c. elegans.

Cross-referencesi

Web resourcesi

Protein Spotlight

The power behind pain - Issue 82 of May 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72504 Genomic DNA. Translation: CAA96603.3.
PIRiT19552.
RefSeqiNP_502249.3. NM_069848.4.
UniGeneiCel.5648.

3D structure databases

ProteinModelPortaliQ18297.
SMRiQ18297. Positions 49-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61523N.
STRINGi6239.C29E6.2.

Protein family/group databases

TCDBi1.A.4.6.5. the transient receptor potential ca(2+) channel (trp-cc) family.

Proteomic databases

EPDiQ18297.
PaxDbiQ18297.
PRIDEiQ18297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC29E6.2a; C29E6.2a; WBGene00007801.
GeneIDi178118.
KEGGicel:CELE_C29E6.2.
UCSCiC29E6.2. c. elegans.

Organism-specific databases

CTDi178118.
WormBaseiC29E6.2a; CE42588; WBGene00007801; trpa-1.

Phylogenomic databases

eggNOGiKOG0510. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129770.
HOGENOMiHOG000017923.
InParanoidiQ18297.
OMAiLLMKDEM.
OrthoDBiEOG7P02H2.
PhylomeDBiQ18297.

Enzyme and pathway databases

ReactomeiR-CEL-3295583. TRP channels.

Miscellaneous databases

PROiQ18297.

Gene expression databases

ExpressionAtlasiQ18297. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF12796. Ank_2. 5 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 17 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTRPA1_CAEEL
AccessioniPrimary (citable) accession number: Q18297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 126 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.