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Q18253

- DPF2_CAEEL

UniProt

Q18253 - DPF2_CAEEL

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Protein
Dipeptidyl peptidase family member 2
Gene
dpf-2, C27C12.7
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Removes N-terminal dipeptides sequentially from polypeptides By similarity. Essential for control of distal tip cell migration.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei691 – 6911Charge relay system By similarity
Active sitei768 – 7681Charge relay system By similarity
Active sitei800 – 8001Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.A74.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase family member 2 (EC:3.4.14.-)
Gene namesi
Name:dpf-2
ORF Names:C27C12.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiC27C12.7; CE05324; WBGene00001055; dpf-2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei28 – 4821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini49 – 829781Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Dipeptidyl peptidase family member 2
PRO_0000248535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...)2 Publications
Glycosylationi359 – 3591N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi514 ↔ 533 By similarity
Disulfide bondi711 ↔ 821 By similarity
Glycosylationi754 – 7541N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ18253.
PRIDEiQ18253.

Interactioni

Protein-protein interaction databases

STRINGi6239.C27C12.7.

Structurei

3D structure databases

ProteinModelPortaliQ18253.
SMRiQ18253. Positions 87-823.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00740000115496.
HOGENOMiHOG000018328.
InParanoidiQ18253.
OMAiCAISIAP.
OrthoDBiEOG71CFKC.
PhylomeDBiQ18253.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q18253-1 [UniParc]FASTAAdd to Basket

« Hide

MENDNYDVEE QGCSVFNGKH GYFARSCCVV FILIICVIFV FSVIFTFMQN    50
PINLNSDNGF NQTSGNTSSL EATTLKPKFS SLMTTTRRFT FEQLFSGKQF 100
LVDYYDYIWL PDGSFVQMND DFTIRKQMKK IPLGSSVAEP FFNNGEYVKA 150
LSSNMKYAYG SKKVNELWRH SAEYLYHIVK INNKTVSTEQ WHVGPEENSL 200
IQAFYWNPNA SSNDFVYVHN YNLYYQKDPE KPDGAIQLTV GGSTFNRFGL 250
ANWLYEEEIL EASSAVWWSP SGRYVSYLRF DDREVNRIFL PKYTDDDSYV 300
EYFELPYPKA GVQNNTLVTQ YIWDSENHKI VETAPPNELS AANGDYYVLT 350
NKWITMPRNG SDLGEERLVT VWANRDQNHV YFSLCNEQDC VMALSFQFSI 400
DNRQLWVSPK DVRGVFPTET GFLTVLPHKH DDGNIYNHVA HVELDGTGTG 450
KITKWIGENF DVILVLGYSS KIDALTFSAY GDGVGEFSTY IVREAMYSNK 500
KTTLQKVTDQ FEDCKTLGSQ SADPTGQRIV VQCEKPFDNT RLYLVDVVDT 550
TKKIMLEGGT KAVIPFDVPN MKFGKLKLPS GIDGHYMMLT PANLLDGAKI 600
PLLLDIYGGP DSKQVFQKTP TAHAIQIVSQ YDIAYARIDV RGTGGRGWDV 650
KEAVYRKLGD AEVVDTLDMI RAFINTFGFI DEDRIAVMGW SYGGFLTSKI 700
AIKDQGELVK CAISIAPVTD FKYYDSAYTE RYLGQPAENL QGYINTNVIP 750
HARNVTNVKY LLAHGERDDN VHYQNSARWS EALQQNGIHF TQLVYANEAH 800
SLSHKLFHLY GEVQRFLMND CFKSNLDLL 829
Length:829
Mass (Da):94,387
Last modified:November 1, 1996 - v1
Checksum:iB3F76F6DC12E44A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69883 Genomic DNA. Translation: CAA93743.1.
PIRiT19514.
RefSeqiNP_510461.1. NM_078060.6.
UniGeneiCel.5433.

Genome annotation databases

EnsemblMetazoaiC27C12.7; C27C12.7; WBGene00001055.
GeneIDi181579.
KEGGicel:CELE_C27C12.7.
UCSCiC27C12.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69883 Genomic DNA. Translation: CAA93743.1 .
PIRi T19514.
RefSeqi NP_510461.1. NM_078060.6.
UniGenei Cel.5433.

3D structure databases

ProteinModelPortali Q18253.
SMRi Q18253. Positions 87-823.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.C27C12.7.

Protein family/group databases

MEROPSi S09.A74.

Proteomic databases

PaxDbi Q18253.
PRIDEi Q18253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C27C12.7 ; C27C12.7 ; WBGene00001055 .
GeneIDi 181579.
KEGGi cel:CELE_C27C12.7.
UCSCi C27C12.7. c. elegans.

Organism-specific databases

CTDi 181579.
WormBasei C27C12.7 ; CE05324 ; WBGene00001055 ; dpf-2.

Phylogenomic databases

eggNOGi COG1506.
GeneTreei ENSGT00740000115496.
HOGENOMi HOG000018328.
InParanoidi Q18253.
OMAi CAISIAP.
OrthoDBi EOG71CFKC.
PhylomeDBi Q18253.

Miscellaneous databases

NextBioi 914522.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
    Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
    Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.
  3. "Dipeptidyl peptidase IV-like protease family is essential for control of distal tip cell migration in C. elegans."
    Yoshina S., Gengyo-Ando K., Mitani S., Iino Y., Inoue H., Takahashi K.
    (In) Proceedings of the 15th international C. elegans meeting, pp.402-402, Los Angeles (2005)
    Cited for: FUNCTION.
  4. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiDPF2_CAEEL
AccessioniPrimary (citable) accession number: Q18253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi