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Q18253

- DPF2_CAEEL

UniProt

Q18253 - DPF2_CAEEL

Protein

Dipeptidyl peptidase family member 2

Gene

dpf-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Removes N-terminal dipeptides sequentially from polypeptides By similarity. Essential for control of distal tip cell migration.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei691 – 6911Charge relay systemBy similarity
    Active sitei768 – 7681Charge relay systemBy similarity
    Active sitei800 – 8001Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.A74.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase family member 2 (EC:3.4.14.-)
    Gene namesi
    Name:dpf-2
    ORF Names:C27C12.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiC27C12.7; CE05324; WBGene00001055; dpf-2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 829829Dipeptidyl peptidase family member 2PRO_0000248535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)2 Publications
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi514 ↔ 533By similarity
    Disulfide bondi711 ↔ 821By similarity
    Glycosylationi754 – 7541N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ18253.
    PRIDEiQ18253.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.C27C12.7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ18253.
    SMRiQ18253. Positions 87-823.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 829781ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family. DPPIV subfamily.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.
    GeneTreeiENSGT00740000115496.
    HOGENOMiHOG000018328.
    InParanoidiQ18253.
    OMAiCAISIAP.
    OrthoDBiEOG71CFKC.
    PhylomeDBiQ18253.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q18253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENDNYDVEE QGCSVFNGKH GYFARSCCVV FILIICVIFV FSVIFTFMQN    50
    PINLNSDNGF NQTSGNTSSL EATTLKPKFS SLMTTTRRFT FEQLFSGKQF 100
    LVDYYDYIWL PDGSFVQMND DFTIRKQMKK IPLGSSVAEP FFNNGEYVKA 150
    LSSNMKYAYG SKKVNELWRH SAEYLYHIVK INNKTVSTEQ WHVGPEENSL 200
    IQAFYWNPNA SSNDFVYVHN YNLYYQKDPE KPDGAIQLTV GGSTFNRFGL 250
    ANWLYEEEIL EASSAVWWSP SGRYVSYLRF DDREVNRIFL PKYTDDDSYV 300
    EYFELPYPKA GVQNNTLVTQ YIWDSENHKI VETAPPNELS AANGDYYVLT 350
    NKWITMPRNG SDLGEERLVT VWANRDQNHV YFSLCNEQDC VMALSFQFSI 400
    DNRQLWVSPK DVRGVFPTET GFLTVLPHKH DDGNIYNHVA HVELDGTGTG 450
    KITKWIGENF DVILVLGYSS KIDALTFSAY GDGVGEFSTY IVREAMYSNK 500
    KTTLQKVTDQ FEDCKTLGSQ SADPTGQRIV VQCEKPFDNT RLYLVDVVDT 550
    TKKIMLEGGT KAVIPFDVPN MKFGKLKLPS GIDGHYMMLT PANLLDGAKI 600
    PLLLDIYGGP DSKQVFQKTP TAHAIQIVSQ YDIAYARIDV RGTGGRGWDV 650
    KEAVYRKLGD AEVVDTLDMI RAFINTFGFI DEDRIAVMGW SYGGFLTSKI 700
    AIKDQGELVK CAISIAPVTD FKYYDSAYTE RYLGQPAENL QGYINTNVIP 750
    HARNVTNVKY LLAHGERDDN VHYQNSARWS EALQQNGIHF TQLVYANEAH 800
    SLSHKLFHLY GEVQRFLMND CFKSNLDLL 829
    Length:829
    Mass (Da):94,387
    Last modified:November 1, 1996 - v1
    Checksum:iB3F76F6DC12E44A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69883 Genomic DNA. Translation: CAA93743.1.
    PIRiT19514.
    RefSeqiNP_510461.1. NM_078060.6.
    UniGeneiCel.5433.

    Genome annotation databases

    EnsemblMetazoaiC27C12.7; C27C12.7; WBGene00001055.
    GeneIDi181579.
    KEGGicel:CELE_C27C12.7.
    UCSCiC27C12.7. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69883 Genomic DNA. Translation: CAA93743.1 .
    PIRi T19514.
    RefSeqi NP_510461.1. NM_078060.6.
    UniGenei Cel.5433.

    3D structure databases

    ProteinModelPortali Q18253.
    SMRi Q18253. Positions 87-823.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.C27C12.7.

    Protein family/group databases

    MEROPSi S09.A74.

    Proteomic databases

    PaxDbi Q18253.
    PRIDEi Q18253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C27C12.7 ; C27C12.7 ; WBGene00001055 .
    GeneIDi 181579.
    KEGGi cel:CELE_C27C12.7.
    UCSCi C27C12.7. c. elegans.

    Organism-specific databases

    CTDi 181579.
    WormBasei C27C12.7 ; CE05324 ; WBGene00001055 ; dpf-2.

    Phylogenomic databases

    eggNOGi COG1506.
    GeneTreei ENSGT00740000115496.
    HOGENOMi HOG000018328.
    InParanoidi Q18253.
    OMAi CAISIAP.
    OrthoDBi EOG71CFKC.
    PhylomeDBi Q18253.

    Miscellaneous databases

    NextBioi 914522.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins."
      Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J., Kasai K., Takahashi N., Isobe T.
      Nat. Biotechnol. 21:667-672(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.
    3. "Dipeptidyl peptidase IV-like protease family is essential for control of distal tip cell migration in C. elegans."
      Yoshina S., Gengyo-Ando K., Mitani S., Iino Y., Inoue H., Takahashi K.
      (In) Proceedings of the 15th international C. elegans meeting, pp.402-402, Los Angeles (2005)
      Cited for: FUNCTION.
    4. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
      Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
      Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-314, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiDPF2_CAEEL
    AccessioniPrimary (citable) accession number: Q18253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3