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Protein

Ras-related protein Rap-1

Gene

rap-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required in the hypodermis for proper formation of the cuticle.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi116 – 1194GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: WormBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • collagen and cuticulin-based cuticle development Source: WormBase
  • epidermis development Source: WormBase
  • intracellular protein transport Source: InterPro
  • nucleocytoplasmic transport Source: InterPro
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-354192. Integrin alphaIIb beta3 signaling.
R-CEL-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CEL-372708. p130Cas linkage to MAPK signaling for integrins.
R-CEL-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-CEL-392517. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap-1
Gene namesi
Name:rap-1
ORF Names:C27B7.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC27B7.8; CE03037; WBGene00004307; rap-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Worms are viable and fertile but display molting defect. Longitudinal ridges termed alae, which are cuticular structures secreted by lateral hypodermal seam cells, are poorly distinct or interrupted. Died as a 'bag of worms' after degeneration of the proximal gonad, or alternatively, as a result of a burst vulva.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Ras-related protein Rap-1PRO_0000423877Add
BLAST

Proteomic databases

EPDiQ18246.
PaxDbiQ18246.
PRIDEiQ18246.

Interactioni

Protein-protein interaction databases

IntActiQ18246. 1 interaction.
STRINGi6239.C27B7.8.

Structurei

3D structure databases

ProteinModelPortaliQ18246.
SMRiQ18246. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
InParanoidiQ18246.
KOiK04353.
OMAiKDQGANL.
OrthoDBiEOG7QVM41.
PhylomeDBiQ18246.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKIVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDGQQ
60 70 80 90 100
CMLEILDTAG TEQFTAMRDL YMKNGQGFVL VYSITAQSTF NDLMDLRDQI
110 120 130 140 150
LRVKDTDEVP MILVGNKCDL EDERVVGKDQ GQNLARQFGS AFLETSAKAK
160 170 180
INVSEVFYDL VRQINRRYPE SGRRQGQSNK QCCSCVIM
Length:188
Mass (Da):21,248
Last modified:November 1, 1996 - v1
Checksum:i45227D8B94C40629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54236 Genomic DNA. Translation: CAA90983.1.
PIRiT19507.
RefSeqiNP_501549.1. NM_069148.4.
UniGeneiCel.7277.

Genome annotation databases

EnsemblMetazoaiC27B7.8; C27B7.8; WBGene00004307.
GeneIDi177709.
KEGGicel:CELE_C27B7.8.
UCSCiC27B7.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54236 Genomic DNA. Translation: CAA90983.1.
PIRiT19507.
RefSeqiNP_501549.1. NM_069148.4.
UniGeneiCel.7277.

3D structure databases

ProteinModelPortaliQ18246.
SMRiQ18246. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ18246. 1 interaction.
STRINGi6239.C27B7.8.

Proteomic databases

EPDiQ18246.
PaxDbiQ18246.
PRIDEiQ18246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC27B7.8; C27B7.8; WBGene00004307.
GeneIDi177709.
KEGGicel:CELE_C27B7.8.
UCSCiC27B7.8. c. elegans.

Organism-specific databases

CTDi177709.
WormBaseiC27B7.8; CE03037; WBGene00004307; rap-1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
InParanoidiQ18246.
KOiK04353.
OMAiKDQGANL.
OrthoDBiEOG7QVM41.
PhylomeDBiQ18246.

Enzyme and pathway databases

ReactomeiR-CEL-354192. Integrin alphaIIb beta3 signaling.
R-CEL-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CEL-372708. p130Cas linkage to MAPK signaling for integrins.
R-CEL-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-CEL-392517. Rap1 signalling.

Miscellaneous databases

PROiQ18246.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity."
    Berkel W.P., Verheijen M.H., Cuppen E., Asahina M., de Rooij J., Jansen G., Plasterk R.H., Bos J.L., Zwartkruis F.J.
    Mol. Biol. Cell 16:106-116(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRAP1_CAEEL
AccessioniPrimary (citable) accession number: Q18246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.