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Protein
Submitted name:

DiSHevelled related

Gene

dsh-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • asymmetric cell division Source: WormBase
  • asymmetric protein localization Source: WormBase
  • canonical Wnt signaling pathway Source: GO_Central
  • cell fate specification Source: WormBase
  • digestive tract morphogenesis Source: WormBase
  • embryonic digestive tract morphogenesis Source: UniProtKB
  • embryonic morphogenesis Source: WormBase
  • endodermal cell fate specification Source: WormBase
  • establishment of mitotic spindle orientation Source: WormBase
  • gonad morphogenesis Source: WormBase
  • intracellular signal transduction Source: InterPro
  • left/right axis specification Source: UniProtKB
  • Wnt signaling pathway Source: WormBase
  • Wnt signaling pathway, planar cell polarity pathway Source: GO_Central
  • Wnt signaling pathway, regulating spindle positioning Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-201688. WNT mediated activation of DVL.
R-CEL-4086400. PCP/CE pathway.
R-CEL-4641258. Degradation of DVL.
R-CEL-5099900. WNT5A-dependent internalization of FZD4.
R-CEL-5663220. RHO GTPases Activate Formins.
SignaLinkiQ18239.

Names & Taxonomyi

Protein namesi
Submitted name:
DiSHevelled relatedImported
Gene namesi
Name:dsh-2Imported
ORF Names:C27A2.6Imported, CELE_C27A2.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC27A2.6; CE50438; WBGene00001102; dsh-2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: WormBase
  • cytosol Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ18239.
PaxDbiQ18239.
PRIDEiQ18239.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-24740N.
IntActiQ18239. 19 interactions.
MINTiMINT-251465.
STRINGi6239.C27A2.6.

Structurei

3D structure databases

ProteinModelPortaliQ18239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 18484DIXInterPro annotationAdd
BLAST
Domaini360 – 44687PDZ (DHR)InterPro annotationAdd
BLAST
Domaini535 – 60975DEPInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3571. Eukaryota.
ENOG410Y5G4. LUCA.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
InParanoidiQ18239.
OMAiCTVIAAK.
OrthoDBiEOG7BP82N.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q18239-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSPSPIDS SFDASDVATP CTVIAAKISL RNRNGLEEDQ ENLDSFDAFT
60 70 80 90 100
ETHETQESKN IAHGEHEEDV SNIYVDDFSK EFGDTVSSVM EPLPKPLTFA
110 120 130 140 150
RTITKVYCHL DDQEHPYMVE VHVPPDCITL RDVKRKLMRT NFKYYCIALD
160 170 180 190 200
PDTGLEVKAE VRDDSRRLYP LKNGRFELYL LTVEGSVHSD TSSGRHRRKQ
210 220 230 240 250
DGSSKGSSGS REYLRAAHHY DNPTPFSDDE SQASSLPTYV KKAHAYNRKH
260 270 280 290 300
APQAYERHLP HMKHNNRHNH HRQNHYEEST FDVTTESDDH YRDGVTYYDE
310 320 330 340 350
DEDDSRSINT DLTSVSQVHL KQKWRQQQKE MRNKWKRMPS ISTASSSFSS
360 370 380 390 400
ITESSMGLEV ITVRLNLETI PLGMTPSGHT NARGDAGLYV GDIQDRGAVA
410 420 430 440 450
LDGRIDIGDM IVGINEISLG NYSNKEAVQL LREAVQRQYL TLTIAKTGDP
460 470 480 490 500
KQNAFPRNPR AEPIRPIDPN EWVKHATNAM KAMPSISEES SSTPIPDDWP
510 520 530 540 550
TNSSASGTPF GGPPPANCLN VMTDKKYVVE VMAAPGSGLD IKDRYWFKIP
560 570 580 590 600
IPMSFLGTDL VEWLVKHVQG LETKKKAREF AEEMLKLGYI RPGVGKQSFT
610 620 630 640 650
KECYYVMGDE CADYTQLRGP DGGYKYPQSH ASSASGHSSN NLIFPPSMYP
660 670 680 690 700
PQPPTAGAVH HRNSVILPSS MTGGYASLPA SPFPHGKASV NDCRRTRDDQ
710 720 730 740 750
RSQASGSSRG SSRRYVELPR KPASLSSGSG LAVDLDRVAS RSSFRAAMNG

SHPQFNIDN
Length:759
Mass (Da):84,695
Last modified:November 11, 2015 - v5
Checksum:iC18BDC42480D9749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD63074.2.
RefSeqiNP_494937.4. NM_062536.6.

Genome annotation databases

EnsemblMetazoaiC27A2.6; C27A2.6; WBGene00001102.
GeneIDi266854.
KEGGicel:CELE_C27A2.6.
UCSCiC27A2.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD63074.2.
RefSeqiNP_494937.4. NM_062536.6.

3D structure databases

ProteinModelPortaliQ18239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24740N.
IntActiQ18239. 19 interactions.
MINTiMINT-251465.
STRINGi6239.C27A2.6.

Proteomic databases

EPDiQ18239.
PaxDbiQ18239.
PRIDEiQ18239.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC27A2.6; C27A2.6; WBGene00001102.
GeneIDi266854.
KEGGicel:CELE_C27A2.6.
UCSCiC27A2.6. c. elegans.

Organism-specific databases

CTDi266854.
WormBaseiC27A2.6; CE50438; WBGene00001102; dsh-2.

Phylogenomic databases

eggNOGiKOG3571. Eukaryota.
ENOG410Y5G4. LUCA.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
InParanoidiQ18239.
OMAiCTVIAAK.
OrthoDBiEOG7BP82N.

Enzyme and pathway databases

ReactomeiR-CEL-201688. WNT mediated activation of DVL.
R-CEL-4086400. PCP/CE pathway.
R-CEL-4641258. Degradation of DVL.
R-CEL-5099900. WNT5A-dependent internalization of FZD4.
R-CEL-5663220. RHO GTPases Activate Formins.
SignaLinkiQ18239.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ18239_CAEEL
AccessioniPrimary (citable) accession number: Q18239
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 11, 2015
Last modified: July 6, 2016
This is version 126 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.